Basic Information:

  VIRBase ID:  

VHID00277442

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          PSMD11:  NM_001270482     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	PSMD11
miRBase Accession/Entrez ID	MIMAT0000995	5717
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	p44.5//Rpn6//S9

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PSMD11	chr17:30803106(+) A-I      intronic chr17:30786045(+) A-I      intronic chr17:30776227(+) A-I      intronic chr17:30803226(+) A-I      intronic chr17:30803242(+) A-I      intronic chr17:30777804(+) A-I      intronic chr17:30776236(+) A-I      intronic chr17:30776292(+) A-I      intronic chr17:30786058(+) A-I      intronic chr17:30803245(+) A-I      intronic chr17:30802831(+) A-I      intronic chr17:30803075(+) A-I      intronic chr17:30803565(+) A-I      intronic chr17:30776260(+) A-I      intronic chr17:30777353(+) A-I      intronic chr17:30786062(+) A-I      intronic chr17:30803235(+) A-I      intronic chr17:30803292(+) A-I      intronic chr17:30777188(+) A-I      intronic chr17:30777194(+) A-I      intronic chr17:30777226(+) A-I      intronic chr17:30777231(+) A-I      intronic chr17:30777259(+) A-I      intronic chr17:30803006(+) A-I      intronic chr17:30777802(+) A-I      intronic chr17:30777826(+) A-I      intronic chr17:30777866(+) A-I      intronic chr17:30777984(+) A-I      intronic chr17:30777985(+) A-I      intronic chr17:30778039(+) A-I      intronic chr17:30778067(+) A-I      intronic chr17:30778800(+) A-I      intronic chr17:30778948(+) A-I      intronic chr17:30778969(+) A-I      intronic chr17:30778986(+) A-I      intronic chr17:30784299(+) A-I      intronic chr17:30784373(+) A-I      intronic chr17:30784385(+) A-I      intronic chr17:30785984(+) A-I      intronic chr17:30785992(+) A-I      intronic chr17:30785993(+) A-I      intronic chr17:30776263(+) A-I      intronic chr17:30786034(+) A-I      intronic chr17:30786362(+) A-I      intronic chr17:30786006(+) A-I      intronic chr17:30786367(+) A-I      intronic chr17:30786376(+) A-I      intronic chr17:30786378(+) A-I      intronic chr17:30786384(+) A-I      intronic chr17:30786783(+) A-I      intronic chr17:30786879(+) A-I      intronic chr17:30800375(+) A-I      intronic chr17:30800452(+) A-I      intronic chr17:30800461(+) A-I      intronic chr17:30802716(+) A-I      intronic chr17:30802792(+) A-I      intronic chr17:30802863(+) A-I      intronic chr17:30804033(+) A-I      intronic chr17:30803967(+) A-I      intronic chr17:30803912(+) A-I      intronic chr17:30803886(+) A-I      intronic chr17:30803844(+) A-I      intronic chr17:30803823(+) A-I      intronic chr17:30803234(+) A-I      intronic chr17:30803230(+) A-I      intronic chr17:30803214(+) A-I      intronic chr17:30788222(+) A-I      intronic chr17:30788253(+) A-I      intronic chr17:30788474(+) A-I      intronic chr17:30803206(+) A-I      intronic chr17:30803182(+) A-I      intronic chr17:30803166(+) A-I      intronic chr17:30803135(+) A-I      intronic chr17:30803083(+) A-I      intronic chr17:30803035(+) A-I      intronic chr17:30803143(+) A-I      intronic chr17:30792777(+) A-I      intronic chr17:30792752(+) A-I      intronic chr17:30792745(+) A-I      intronic chr17:30792399(+) A-I      intronic chr17:30792383(+) A-I      intronic chr17:30788510(+) A-I      intronic chr17:30788482(+) A-I      intronic chr17:30776270(+) A-I      intronic chr17:30788478(+) A-I      intronic chr17:30800000(+) A-I      intronic chr17:30799959(+) A-I      intronic chr17:30799685(+) A-I      intronic chr17:30793289(+) A-I      intronic chr17:30793195(+) A-I      intronic chr17:30792921(+) A-I      intronic chr17:30792873(+) A-I      intronic chr17:30776264(+) A-I      intronic chr17:30776265(+) A-I      intronic chr17:30776351(+) A-I      intronic chr17:30776405(+) A-I      intronic chr17:30777105(+) A-I      intronic chr17:30775479(+) A-I      intronic chr17:30776173(+) A-I      intronic chr17:30776208(+) A-I      intronic chr17:30776217(+) A-I      intronic chr17:30777114(+) A-I      intronic chr17:30777120(+) A-I      intronic chr17:30776168(+) A-I      intronic chr17:30778059(+) A-I      intronic chr17:30803201(+) A-I      intronic chr17:30788469(+) A-I      intronic chr17:30784483(+) A-I      intronic chr17:30803229(+) A-I      intronic chr17:30778107(+) A-I      intronic chr17:30778886(+) A-I      intronic chr17:30777115(+) A-I      intronic chr17:30800394(+) A-I      intronic chr17:30800685(+) A-I      intronic chr17:30802734(+) A-I      intronic chr17:30777829(+) A-I      intronic chr17:30803111(+) A-I      intronic chr17:30775065(+) A-I      intronic chr17:30799778(+) A-I      intronic chr17:30778883(+) A-I      intronic chr17:30800215(+) A-I      intronic chr17:30776241(+) A-I      intronic chr17:30778860(+) A-I      intronic chr17:30777413(+) A-I      intronic chr17:30793249(+) A-I      intronic chr17:30802840(+) A-I      intronic chr17:30777159(+) A-I      intronic chr17:30803072(+) A-I      intronic chr17:30777850(+) A-I      intronic chr17:30776411(+) A-I      intronic chr17:30793280(+) A-I      intronic chr17:30799829(+) A-I      intronic chr17:30802717(+) A-I      intronic chr17:30777240(+) A-I      intronic chr17:30777241(+) A-I      intronic chr17:30778780(+) A-I      intronic chr17:30803220(+) A-I      intronic chr17:30799451(+) A-I      intronic chr17:30776224(+) A-I      intronic chr17:30778831(+) A-I      intronic chr17:30799393(+) A-I      intronic chr17:30779022(+) A-I      intronic chr17:30787529(+) A-I      intronic chr17:30803179(+) A-I      intronic chr17:30777145(+) A-I      intronic chr17:30776242(+) A-I      intronic chr17:30776237(+) A-I      intronic chr17:30778036(+) A-I      intronic chr17:30800056(+) A-I      intronic chr17:30788213(+) A-I      intronic chr17:30777373(+) A-I      intronic chr17:30786436(+) A-I      intronic chr17:30778909(+) A-I      intronic chr17:30778957(+) A-I      intronic chr17:30788424(+) A-I      intronic chr17:30803883(+) A-I      intronic chr17:30802833(+) A-I      intronic chr17:30775016(+) A-I      intronic chr17:30800121(+) A-I      intronic chr17:30777253(+) A-I      intronic chr17:30779009(+) A-I      intronic chr17:30775653(+) A-I      intronic chr17:30775038(+) A-I      intronic chr17:30777546(+) A-I      intronic chr17:30803049(+) A-I      intronic chr17:30787262(+) A-I      intronic chr17:30792831(+) A-I      intronic chr17:30788235(+) A-I      intronic chr17:30802691(+) A-I      intronic chr17:30776343(+) A-I      intronic chr17:30785966(+) A-I      intronic chr17:30776393(+) A-I      intronic chr17:30777179(+) A-I      intronic chr17:30800550(+) A-I      intronic chr17:30799817(+) A-I      intronic chr17:30803909(+) A-I      intronic chr17:30776184(+) A-I      intronic chr17:30778788(+) A-I      intronic chr17:30788225(+) A-I      intronic chr17:30799816(+) A-I      intronic chr17:30778887(+) A-I      intronic chr17:30793033(+) A-I      intronic chr17:30778856(+) A-I      intronic chr17:30777843(+) A-I      intronic chr17:30800042(+) A-I      intronic chr17:30803847(+) A-I      intronic chr17:30788369(+) A-I      intronic chr17:30778931(+) A-I      intronic chr17:30803103(+) A-I      intronic chr17:30784341(+) A-I      intronic chr17:30776267(+) A-I      intronic chr17:30800359(+) A-I      intronic chr17:30803256(+) A-I      intronic chr17:30774920(+) A-I      intronic chr17:30776239(+) A-I      intronic chr17:30800015(+) A-I      intronic chr17:30802681(+) A-I      intronic chr17:30803908(+) A-I      intronic chr17:30777096(+) A-I      intronic chr17:30776145(+) A-I      intronic chr17:30802746(+) A-I      intronic chr17:30788157(+) A-I      intronic chr17:30777990(+) A-I      intronic chr17:30783533(+) A-I      intronic chr17:30799574(+) A-I      intronic chr17:30803188(+) A-I      intronic chr17:30803198(+) A-I      intronic chr17:30800450(+) A-I      intronic chr17:30783421(+) A-I      intronic chr17:30799023(+) A-I      intronic chr17:30778776(+) A-I      intronic chr17:30774999(+) A-I      intronic chr17:30802782(+) A-I      intronic chr17:30793114(+) A-I      intronic chr17:30787288(+) A-I      intronic chr17:30793215(+) A-I      intronic chr17:30778801(+) A-I      intronic chr17:30776410(+) A-I      intronic chr17:30778983(+) A-I      intronic chr17:30777862(+) A-I      intronic chr17:30788442(+) A-I      intronic chr17:30802801(+) A-I      intronic chr17:30803922(+) A-I      intronic chr17:30776276(+) A-I      intronic chr17:30799964(+) A-I      intronic chr17:30775485(+) A-I      intronic chr17:30800253(+) A-I      intronic chr17:30777978(+) A-I      intronic chr17:30800460(+) A-I      intronic chr17:30775466(+) A-I      intronic chr17:30786761(+) A-I      intronic chr17:30777994(+) A-I      intronic chr17:30776258(+) A-I      intronic chr17:30786336(+) A-I      intronic chr17:30777814(+) A-I      intronic chr17:30776332(+) A-I      intronic chr17:30778874(+) A-I      intronic chr17:30786845(+) A-I      intronic chr17:30799735(+) A-I      intronic chr17:30799835(+) A-I      intronic chr17:30776262(+) A-I      intronic chr17:30779010(+) A-I      intronic chr17:30802710(+) A-I      intronic chr17:30803175(+) A-I      intronic chr17:30775407(+) A-I      intronic chr17:30775665(+) A-I      intronic chr17:30802721(+) A-I      intronic chr17:30803267(+) A-I      intronic chr17:30799744(+) A-I      intronic chr17:30798918(+) A-I      intronic chr17:30800427(+) A-I      intronic chr17:30775460(+) A-I      intronic chr17:30799764(+) A-I      intronic chr17:30793045(+) A-I      intronic chr17:30800424(+) A-I      intronic chr17:30788539(+) A-I      intronic chr17:30800434(+) A-I      intronic chr17:30774979(+) A-I      intronic chr17:30799636(+) A-I      intronic chr17:30776312(+) A-I      intronic chr17:30775486(+) A-I      intronic chr17:30800178(+) A-I      intronic chr17:30803957(+) A-I      intronic chr17:30777821(+) A-I      intronic chr17:30777118(+) A-I      intronic chr17:30776348(+) A-I      intronic chr17:30800276(+) A-I      intronic chr17:30784335(+) A-I      intronic chr17:30777980(+) A-I      intronic chr17:30777547(+) A-I      intronic chr17:30792737(+) A-I      intronic chr17:30788468(+) A-I      intronic chr17:30777896(+) A-I      intronic chr17:30803148(+) A-I      intronic chr17:30777214(+) A-I      intronic chr17:30779016(+) A-I      intronic chr17:30778054(+) A-I      intronic chr17:30778068(+) A-I      intronic chr17:30802832(+) A-I      intronic chr17:30788433(+) A-I      intronic chr17:30800532(+) A-I      intronic chr17:30802871(+) A-I      intronic chr17:30799973(+) A-I      intronic chr17:30800456(+) A-I      intronic chr17:30776302(+) A-I      intronic chr17:30777218(+) A-I      intronic chr17:30792759(+) A-I      intronic chr17:30802864(+) A-I      intronic chr17:30799695(+) A-I      intronic chr17:30777908(+) A-I      intronic chr17:30778127(+) A-I      intronic chr17:30784395(+) A-I      intronic chr17:30775028(+) A-I      intronic chr17:30786311(+) A-I      intronic chr17:30800104(+) A-I      intronic chr17:30776378(+) A-I      intronic chr17:30777215(+) A-I      intronic chr17:30776194(+) A-I      intronic chr17:30778807(+) A-I      intronic chr17:30792736(+) A-I      intronic chr17:30778072(+) A-I      intronic chr17:30777956(+) A-I      intronic chr17:30786703(+) A-I      intronic chr17:30802839(+) A-I      intronic chr17:30788514(+) A-I      intronic chr17:30792801(+) A-I      intronic chr17:30802795(+) A-I      intronic chr17:30802873(+) A-I      intronic chr17:30777838(+) A-I      intronic chr17:30778037(+) A-I      intronic chr17:30800055(+) A-I      intronic chr17:30778950(+) A-I      intronic chr17:30787299(+) A-I      intronic chr17:30783687(+) A-I      intronic chr17:30789761(+) A-I      intronic chr17:30777403(+) A-I      intronic chr17:30776167(+) A-I      intronic chr17:30800029(+) A-I      intronic chr17:30778857(+) A-I      intronic chr17:30799789(+) A-I      intronic chr17:30776325(+) A-I      intronic chr17:30803104(+) A-I      intronic chr17:30792758(+) A-I      intronic chr17:30803105(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PSMD11	chr17:30776194(+) A-I intron -    22327324 chr17:30776302(+) A-I intron -    22327324 chr17:30777838(+) A-I intron -    22327324 chr17:30778054(+) A-I intron -    22327324 chr17:30803220(+) A-I intron -    22327324 chr17:30778780(+) A-I intron -    21960545 chr17:30778887(+) A-I intron -    21960545 chr17:30777120(+) A-I intron -    21960545 chr17:30777179(+) A-I intron -    21960545 chr17:30803820(+) A-I intron -    21960545 chr17:30804005(+) A-I intron -    21960545 chr17:30776145(+) A-G intron -    22484847 chr17:30776168(+) A-G intron -    22484847 chr17:30776194(+) A-G intron -    22484847 chr17:30776241(+) A-G intron -    22484847 chr17:30776242(+) A-G intron -    22484847 chr17:30776302(+) A-G intron -    22484847 chr17:30776343(+) A-G intron -    22484847 chr17:30776411(+) A-G intron -    22484847 chr17:30777159(+) A-G intron -    22484847 chr17:30777179(+) A-G intron -    22484847 chr17:30777214(+) A-G intron -    22484847 chr17:30777814(+) A-G intron -    22484847 chr17:30777821(+) A-G intron -    22484847 chr17:30777838(+) A-G intron -    22484847 chr17:30777862(+) A-G intron -    22484847 chr17:30777896(+) A-G intron -    22484847 chr17:30778036(+) A-G intron -    22484847 chr17:30778037(+) A-G intron -    22484847 chr17:30778054(+) A-G intron -    22484847 chr17:30778154(+) G-A intron -    22484847 chr17:30778788(+) A-G intron -    22484847 chr17:30778856(+) A-G intron -    22484847 chr17:30778857(+) A-G intron -    22484847 chr17:30778860(+) A-G intron -    22484847 chr17:30778887(+) A-G intron -    22484847 chr17:30778909(+) A-G intron -    22484847 chr17:30802832(+) A-G intron -    22484847 chr17:30803072(+) A-G intron -    22484847 chr17:30803148(+) A-G intron -    22484847 chr17:30803179(+) A-G intron -    22484847 chr17:30803188(+) A-G intron -    22484847 chr17:30803220(+) A-G intron -    22484847 chr17:30803229(+) A-G intron -    22484847 chr17:30803908(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PSMD11	chr17:30771466-30771467(+) m6A 5'UTR       - chr17:30772727-30772728(+) m6A 5'UTR//intron       - chr17:30796199-30796200(+) m6A CDS//exon       26404942 chr17:30800845-30800846(+) m6A CDS//exon       26404942 chr17:30800853-30800854(+) m6A CDS//exon       26404942 chr17:30801065-30801066(+) m6A 3'UTR//intron       22575960 chr17:30804538-30804539(+) m6A 3'UTR//CDS//exon       - chr17:30804575-30804576(+) m6A 3'UTR//CDS//exon       - chr17:30804665-30804666(+) m6A exon//intron       27773535 chr17:30806351-30806352(+) m6A CDS//exon       27773535 chr17:30806400-30806401(+) m6A exon//intron       27773535 chr17:30806411-30806412(+) m6A exon//intron       27773535 chr17:30806873-30806874(+) m6A CDS//exon       27773535 chr17:30806894-30806895(+) m6A CDS//exon       27773535 chr17:30807451-30807452(+) m6A exon//intron       24981863 chr17:30807515-30807516(+) m6A CDS//exon       24981863//26404942//22608085 chr17:30807549-30807550(+) m6A CDS//exon       24981863//26404942//22608085 chr17:30807565-30807566(+) m6A CDS//exon       24981863//26404942//22608085 chr17:30807586-30807587(+) m6A CDS//exon       24981863//26404942//27773535//22608085 chr17:30807596-30807597(+) m6A CDS//exon       24981863//26404942//27773535//22608085 chr17:30807639-30807640(+) m6A CDS//exon       24981863//26404942//27773535//22608085 chr17:30807667-30807668(+) m6A 3'UTR//exon//intron       24981863//27773535//22608085 chr17:30807705-30807706(+) m6A 3'UTR//exon//intron       24981863//22608085 chr17:30807712-30807713(+) m6A 3'UTR//exon//intron       24981863//22608085 chr17:30808206-30808207(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:30808212-30808213(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:30808230-30808231(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:30808540-30808541(+) m6A 3'UTR       24209618//24981863 chr17:30808549-30808550(+) m6A 3'UTR       24209618//24981863 chr17:30808654-30808655(+) m6A 3'UTR       24284625//24981863 chr17:30808916-30808917(+) Tm 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	PSMD11	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: PSMD11

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).