Basic Information:

  VIRBase ID:  

VHID00277249

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          IFNGR2:  NM_005534     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	IFNGR2
miRBase Accession/Entrez ID	MIMAT0000995	3460
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AF-1//IFGR2//IFNGT1//IMD28

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFNGR2	chr21:34803716(+) A-I      intronic chr21:34782702(+) A-I      intronic chr21:34782731(+) A-I      intronic chr21:34803721(+) A-I      intronic chr21:34803766(+) A-I      intronic chr21:34778257(+) A-I      intronic chr21:34808797(+) A-I      intronic chr21:34807975(+) A-I      intronic chr21:34806819(+) A-I      intronic chr21:34805334(+) A-I      intronic chr21:34797247(+) A-I      intronic chr21:34782891(+) A-I      intronic chr21:34782875(+) A-I      intronic chr21:34779966(+) A-I      intronic chr21:34803770(+) A-I      intronic chr21:34803756(+) A-I      intronic chr21:34803727(+) A-I      intronic chr21:34776861(+) A-I      intronic chr21:34808006(+) A-I      intronic chr21:34808034(+) A-I      intronic chr21:34808069(+) A-I      intronic chr21:34808079(+) A-I      intronic chr21:34808105(+) A-I      intronic chr21:34808110(+) A-I      intronic chr21:34808111(+) A-I      intronic chr21:34808752(+) A-I      intronic chr21:34808772(+) A-I      intronic chr21:34808796(+) A-I      intronic chr21:34808820(+) A-I      intronic chr21:34808844(+) A-I      intronic chr21:34808854(+) A-I      intronic chr21:34808870(+) A-I      intronic chr21:34808872(+) A-I      intronic chr21:34808891(+) A-I      intronic chr21:34808908(+) A-I      intronic chr21:34808918(+) A-I      intronic chr21:34808931(+) A-I      intronic chr21:34808935(+) A-I      intronic chr21:34808949(+) A-I      intronic chr21:34808950(+) A-I      intronic chr21:34808958(+) A-I      intronic chr21:34808984(+) A-I      intronic chr21:34808986(+) A-I      intronic chr21:34808999(+) A-I      intronic chr21:34809004(+) A-I      intronic chr21:34777179(+) A-I      intronic chr21:34777184(+) A-I      intronic chr21:34777252(+) A-I      intronic chr21:34807937(+) A-I      intronic chr21:34777434(+) A-I      intronic chr21:34778081(+) A-I      intronic chr21:34778184(+) A-I      intronic chr21:34778285(+) A-I      intronic chr21:34778424(+) A-I      intronic chr21:34778990(+) A-I      intronic chr21:34779018(+) A-I      intronic chr21:34779053(+) A-I      intronic chr21:34780027(+) A-I      intronic chr21:34780085(+) A-I      intronic chr21:34780099(+) A-I      intronic chr21:34805310(+) A-I      intronic chr21:34780583(+) A-I      intronic chr21:34780602(+) A-I      intronic chr21:34780629(+) A-I      intronic chr21:34780633(+) A-I      intronic chr21:34780755(+) A-I      intronic chr21:34781230(+) A-I      intronic chr21:34781330(+) A-I      intronic chr21:34781336(+) A-I      intronic chr21:34781363(+) A-I      intronic chr21:34781389(+) A-I      intronic chr21:34781614(+) A-I      intronic chr21:34781632(+) A-I      intronic chr21:34781644(+) A-I      intronic chr21:34781687(+) A-I      intronic chr21:34781709(+) A-I      intronic chr21:34782512(+) A-I      intronic chr21:34782537(+) A-I      intronic chr21:34782572(+) A-I      intronic chr21:34782576(+) A-I      intronic chr21:34782645(+) A-I      intronic chr21:34782657(+) A-I      intronic chr21:34782658(+) A-I      intronic chr21:34782695(+) A-I      intronic chr21:34782714(+) A-I      intronic chr21:34782732(+) A-I      intronic chr21:34782733(+) A-I      intronic chr21:34782740(+) A-I      intronic chr21:34782745(+) A-I      intronic chr21:34783026(+) A-I      intronic chr21:34786184(+) A-I      intronic chr21:34788449(+) A-I      intronic chr21:34788880(+) A-I      intronic chr21:34788883(+) A-I      intronic chr21:34788982(+) A-I      intronic chr21:34788992(+) A-I      intronic chr21:34789008(+) A-I      intronic chr21:34789559(+) A-I      intronic chr21:34789564(+) A-I      intronic chr21:34789650(+) A-I      intronic chr21:34789675(+) A-I      intronic chr21:34790468(+) A-I      intronic chr21:34791482(+) A-I      intronic chr21:34791513(+) A-I      intronic chr21:34791542(+) A-I      intronic chr21:34791595(+) A-I      intronic chr21:34791615(+) A-I      intronic chr21:34794955(+) A-I      intronic chr21:34794974(+) A-I      intronic chr21:34795008(+) A-I      intronic chr21:34795013(+) A-I      intronic chr21:34795037(+) A-I      intronic chr21:34795096(+) A-I      intronic chr21:34795141(+) A-I      intronic chr21:34795411(+) A-I      intronic chr21:34795427(+) A-I      intronic chr21:34795433(+) A-I      intronic chr21:34795464(+) A-I      intronic chr21:34795522(+) A-I      intronic chr21:34795531(+) A-I      intronic chr21:34795553(+) A-I      intronic chr21:34796122(+) A-I      intronic chr21:34796124(+) A-I      intronic chr21:34796406(+) A-I      intronic chr21:34796407(+) A-I      intronic chr21:34796409(+) A-I      intronic chr21:34796437(+) A-I      intronic chr21:34797141(+) A-I      intronic chr21:34797177(+) A-I      intronic chr21:34797193(+) A-I      intronic chr21:34797388(+) A-I      intronic chr21:34797393(+) A-I      intronic chr21:34797407(+) A-I      intronic chr21:34797419(+) A-I      intronic chr21:34797474(+) A-I      intronic chr21:34798510(+) A-I      intronic chr21:34798677(+) A-I      intronic chr21:34798921(+) A-I      intronic chr21:34798987(+) A-I      intronic chr21:34800202(+) A-I      intronic chr21:34800258(+) A-I      intronic chr21:34800285(+) A-I      intronic chr21:34801671(+) A-I      intronic chr21:34802191(+) A-I      intronic chr21:34802249(+) A-I      intronic chr21:34802287(+) A-I      intronic chr21:34802288(+) A-I      intronic chr21:34802295(+) A-I      intronic chr21:34802296(+) A-I      intronic chr21:34802994(+) A-I      intronic chr21:34802995(+) A-I      intronic chr21:34803022(+) A-I      intronic chr21:34803036(+) A-I      intronic chr21:34803040(+) A-I      intronic chr21:34803622(+) A-I      intronic chr21:34803644(+) A-I      intronic chr21:34803718(+) A-I      intronic chr21:34798486(+) A-I      intronic chr21:34803757(+) A-I      intronic chr21:34803783(+) A-I      intronic chr21:34804003(+) A-I      intronic chr21:34804101(+) A-I      intronic chr21:34804108(+) A-I      intronic chr21:34804113(+) A-I      intronic chr21:34804139(+) A-I      intronic chr21:34804155(+) A-I      intronic chr21:34805212(+) A-I      intronic chr21:34805249(+) A-I      intronic chr21:34805254(+) A-I      intronic chr21:34805257(+) A-I      intronic chr21:34805279(+) A-I      intronic chr21:34805292(+) A-I      intronic chr21:34805322(+) A-I      intronic chr21:34805359(+) A-I      intronic chr21:34805367(+) A-I      intronic chr21:34805380(+) A-I      intronic chr21:34805402(+) A-I      intronic chr21:34805414(+) A-I      intronic chr21:34805422(+) A-I      intronic chr21:34805427(+) A-I      intronic chr21:34805428(+) A-I      intronic chr21:34805436(+) A-I      intronic chr21:34805445(+) A-I      intronic chr21:34805455(+) A-I      intronic chr21:34805467(+) A-I      intronic chr21:34806561(+) A-I      intronic chr21:34806573(+) A-I      intronic chr21:34806574(+) A-I      intronic chr21:34806595(+) A-I      intronic chr21:34806642(+) A-I      intronic chr21:34806673(+) A-I      intronic chr21:34806678(+) A-I      intronic chr21:34806741(+) A-I      intronic chr21:34806764(+) A-I      intronic chr21:34806768(+) A-I      intronic chr21:34806774(+) A-I      intronic chr21:34806813(+) A-I      intronic chr21:34807919(+) A-I      intronic chr21:34807936(+) A-I      intronic chr21:34780137(+) A-I      intronic chr21:34807942(+) A-I      intronic chr21:34807945(+) A-I      intronic chr21:34807951(+) A-I      intronic chr21:34807976(+) A-I      intronic chr21:34807980(+) A-I      intronic chr21:34808004(+) A-I      intronic chr21:34781719(+) A-I      intronic chr21:34786430(+) A-I      intronic chr21:34796446(+) A-I      intronic chr21:34778562(+) A-I      intronic chr21:34789344(+) A-I      intronic chr21:34778206(+) A-I      intronic chr21:34782899(+) A-I      intronic chr21:34803599(+) A-I      intronic chr21:34780676(+) A-I      intronic chr21:34778179(+) A-I      intronic chr21:34796336(+) A-I      intronic chr21:34796447(+) A-I      intronic chr21:34779190(+) A-I      intronic chr21:34806750(+) A-I      intronic chr21:34763509(+) A-I      intronic chr21:34797165(+) A-I      intronic chr21:34793099(+) A-I      intronic chr21:34780577(+) A-I      intronic chr21:34796358(+) A-I      intronic chr21:34796044(+) A-I      intronic chr21:34778279(+) A-I      intronic chr21:34804063(+) A-I      intronic chr21:34788292(+) A-I      intronic chr21:34806679(+) A-I      intronic chr21:34802182(+) A-I      intronic chr21:34805358(+) A-I      intronic chr21:34797489(+) A-I      intronic chr21:34796045(+) A-I      intronic chr21:34782855(+) A-I      intronic chr21:34806791(+) A-I      intronic chr21:34803928(+) A-I      intronic chr21:34778663(+) A-I      intronic chr21:34795023(+) A-I      intronic chr21:34802892(+) A-I      intronic chr21:34777318(+) A-I      intronic chr21:34782873(+) A-I      intronic chr21:34779066(+) A-I      intronic chr21:34795116(+) A-I      intronic chr21:34788952(+) A-I      intronic chr21:34779119(+) A-I      intronic chr21:34804126(+) A-I      intronic chr21:34802862(+) A-I      intronic chr21:34803734(+) A-I      intronic chr21:34797148(+) A-I      intronic chr21:34796493(+) A-I      intronic chr21:34778602(+) A-I      intronic chr21:34798874(+) A-I      intronic chr21:34803763(+) A-I      intronic chr21:34805332(+) A-I      intronic chr21:34778239(+) A-I      intronic chr21:34781408(+) A-I      intronic chr21:34797392(+) A-I      intronic chr21:34795073(+) A-I      intronic chr21:34795019(+) A-I      intronic chr21:34802217(+) A-I      intronic chr21:34796398(+) A-I      intronic chr21:34796487(+) A-I      intronic chr21:34776869(+) A-I      intronic chr21:34803805(+) A-I      intronic chr21:34803741(+) A-I      intronic chr21:34788189(+) A-I      intronic chr21:34778517(+) A-I      intronic chr21:34795977(+) A-I      intronic chr21:34788942(+) A-I      intronic chr21:34795970(+) A-I      intronic chr21:34806653(+) A-I      intronic chr21:34795081(+) A-I      intronic chr21:34789320(+) A-I      intronic chr21:34782598(+) A-I      intronic chr21:34790536(+) A-I      intronic chr21:34783048(+) A-I      intronic chr21:34797462(+) A-I      intronic chr21:34782929(+) A-I      intronic chr21:34806604(+) A-I      intronic chr21:34804039(+) A-I      intronic chr21:34801672(+) A-I      intronic chr21:34797413(+) A-I      intronic chr21:34782566(+) A-I      intronic chr21:34797181(+) A-I      intronic chr21:34797346(+) A-I      intronic chr21:34788238(+) A-I      intronic chr21:34805379(+) A-I      intronic chr21:34782900(+) A-I      intronic chr21:34789659(+) A-I      intronic chr21:34802299(+) A-I      intronic chr21:34806754(+) A-I      intronic chr21:34795908(+) A-I      intronic chr21:34806773(+) A-I      intronic chr21:34780002(+) A-I      intronic chr21:34795057(+) A-I      intronic chr21:34778082(+) A-I      intronic chr21:34796379(+) A-I      intronic chr21:34779093(+) A-I      intronic chr21:34798538(+) A-I      intronic chr21:34802271(+) A-I      intronic chr21:34805382(+) A-I      intronic chr21:34788348(+) A-I      intronic chr21:34779023(+) A-I      intronic chr21:34798865(+) A-I      intronic chr21:34777187(+) A-I      intronic chr21:34795971(+) A-I      intronic chr21:34780632(+) A-I      intronic chr21:34779015(+) A-I      intronic chr21:34797310(+) A-I      intronic chr21:34798600(+) A-I      intronic chr21:34788363(+) A-I      intronic chr21:34802980(+) A-I      intronic chr21:34797187(+) A-I      intronic chr21:34803719(+) A-I      intronic chr21:34781268(+) A-I      intronic chr21:34779152(+) A-I      intronic chr21:34779028(+) A-I      intronic chr21:34777314(+) A-I      intronic chr21:34791539(+) A-I      intronic chr21:34779164(+) A-I      intronic chr21:34805376(+) A-I      intronic chr21:34797356(+) A-I      intronic chr21:34800260(+) A-I      intronic chr21:34802367(+) A-I      intronic chr21:34778075(+) A-I      intronic chr21:34779071(+) A-I      intronic chr21:34789369(+) A-I      intronic chr21:34788430(+) A-I      intronic chr21:34788343(+) A-I      intronic chr21:34780564(+) A-I      intronic chr21:34782517(+) A-I      intronic chr21:34780111(+) A-I      intronic chr21:34777291(+) A-I      intronic chr21:34808014(+) A-I      intronic chr21:34777219(+) A-I      intronic chr21:34796121(+) A-I      intronic chr21:34803619(+) A-I      intronic chr21:34788852(+) A-I      intronic chr21:34779217(+) A-I      intronic chr21:34782954(+) A-I      intronic chr21:34795891(+) A-I      intronic chr21:34794920(+) A-I      intronic chr21:34778603(+) A-I      intronic chr21:34802433(+) A-I      intronic chr21:34796488(+) A-I      intronic chr21:34802281(+) A-I      intronic chr21:34778469(+) A-I      intronic chr21:34776997(+) A-I      intronic chr21:34779995(+) A-I      intronic chr21:34804153(+) A-I      intronic chr21:34797317(+) A-I      intronic chr21:34788346(+) A-I      intronic chr21:34797479(+) A-I      intronic chr21:34796370(+) A-I      intronic chr21:34781519(+) A-I      intronic chr21:34779223(+) A-I      intronic chr21:34804140(+) A-I      intronic chr21:34779054(+) A-I      intronic chr21:34788431(+) A-I      intronic chr21:34778588(+) A-I      intronic chr21:34803797(+) A-I      intronic chr21:34795933(+) A-I      intronic chr21:34780682(+) A-I      intronic chr21:34805393(+) A-I      intronic chr21:34797503(+) A-I      intronic chr21:34805286(+) A-I      intronic chr21:34782939(+) A-I      intronic chr21:34778182(+) A-I      intronic chr21:34803798(+) A-I      intronic chr21:34776843(+) A-I      intronic chr21:34804078(+) A-I      intronic chr21:34778229(+) A-I      intronic chr21:34778280(+) A-I      intronic chr21:34788243(+) A-I      intronic chr21:34802290(+) A-I      intronic chr21:34781696(+) A-I      intronic chr21:34796448(+) A-I      intronic chr21:34803738(+) A-I      intronic chr21:34778454(+) A-I      intronic chr21:34803007(+) A-I      intronic chr21:34798491(+) A-I      intronic chr21:34781598(+) A-I      intronic chr21:34803648(+) A-I      intronic chr21:34802940(+) A-I      intronic chr21:34782599(+) A-I      intronic chr21:34802879(+) A-I      intronic chr21:34801677(+) A-I      intronic chr21:34802896(+) A-I      intronic chr21:34780006(+) A-I      intronic chr21:34802366(+) A-I      intronic chr21:34780019(+) A-I      intronic chr21:34781615(+) A-I      intronic chr21:34808115(+) A-I      intronic chr21:34778161(+) A-I      intronic chr21:34778117(+) A-I      intronic chr21:34798862(+) A-I      intronic chr21:34780620(+) A-I      intronic chr21:34805272(+) A-I      intronic chr21:34806619(+) A-I      intronic chr21:34781641(+) A-I      intronic chr21:34804043(+) A-I      intronic chr21:34803701(+) A-I      intronic chr21:34786195(+) A-I      intronic chr21:34804017(+) A-I      intronic chr21:34782819(+) A-I      intronic chr21:34779189(+) A-I      intronic chr21:34804061(+) A-I      intronic chr21:34776944(+) A-I      intronic chr21:34803754(+) A-I      intronic chr21:34781513(+) A-I      intronic chr21:34788328(+) A-I      intronic chr21:34801694(+) A-I      intronic chr21:34781412(+) A-I      intronic chr21:34779953(+) A-I      intronic chr21:34804007(+) A-I      intronic chr21:34805335(+) A-I      intronic chr21:34793254(+) A-I      intronic chr21:34804035(+) A-I      intronic chr21:34803638(+) A-I      intronic chr21:34781297(+) A-I      intronic chr21:34802876(+) A-I      intronic chr21:34777311(+) A-I      intronic chr21:34782957(+) A-I      intronic chr21:34793098(+) A-I      intronic chr21:34803978(+) A-I      intronic chr21:34796050(+) A-I      intronic chr21:34795063(+) A-I      intronic chr21:34782612(+) A-I      intronic chr21:34804141(+) A-I      intronic chr21:34780028(+) A-I      intronic chr21:34803948(+) A-I      intronic chr21:34790547(+) A-I      intronic chr21:34781574(+) A-I      intronic chr21:34778561(+) A-I      intronic chr21:34796353(+) A-I      intronic chr21:34778162(+) A-I      intronic chr21:34779040(+) A-I      intronic chr21:34782602(+) A-I      intronic chr21:34797118(+) A-I      intronic chr21:34803730(+) A-I      intronic chr21:34803995(+) A-I      intronic chr21:34788225(+) A-I      intronic chr21:34778191(+) A-I      intronic chr21:34801729(+) A-I      intronic chr21:34802303(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFNGR2	chr21:34788363(+) A-I intron -    22327324 chr21:34805286(+) A-I intron -    22327324 chr21:34806754(+) A-I intron -    22327324 chr21:34806791(+) A-I intron -    22327324 chr21:34779953(+) A-I intron -    21960545 chr21:34802231(+) A-I intron -    21960545 chr21:34802781(+) A-I intron -    21960545 chr21:34802862(+) A-I intron -    21960545 chr21:34802879(+) A-I intron -    21960545 chr21:34778239(+) A-G intron -    22484847 chr21:34779071(+) A-G intron -    22484847 chr21:34779164(+) A-G intron -    22484847 chr21:34779223(+) A-G intron -    22484847 chr21:34781719(+) A-G intron -    22484847 chr21:34788243(+) A-G intron -    22484847 chr21:34788363(+) A-G intron -    22484847 chr21:34788430(+) A-G intron -    22484847 chr21:34789659(+) A-G intron -    22484847 chr21:34791539(+) A-G intron -    22484847 chr21:34795019(+) A-G intron -    22484847 chr21:34795022(+) A-G intron -    22484847 chr21:34795023(+) A-G intron -    22484847 chr21:34795024(+) A-G intron -    22484847 chr21:34796443(+) A-G intron -    22484847 chr21:34796446(+) A-G intron -    22484847 chr21:34796447(+) A-G intron -    22484847 chr21:34797334(+) A-G intron -    22484847 chr21:34802213(+) A-G intron -    22484847 chr21:34802217(+) A-G intron -    22484847 chr21:34802862(+) A-G intron -    22484847 chr21:34802879(+) A-G intron -    22484847 chr21:34803007(+) A-G intron -    22484847 chr21:34803012(+) A-G intron -    22484847 chr21:34803701(+) A-G intron -    22484847 chr21:34803948(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNGR2	chr21:34775339-34775340(+) m6A 5'UTR       25456834 chr21:34775796-34775797(+) m6A 5'UTR       24209618 chr21:34783866-34783867(+) m6A 3'UTR//intron       - chr21:34805061-34805062(+) m6A 3'UTR//CDS       27773535 chr21:34809144-34809145(+) m6A 3'UTR//CDS//intron       24209618//24981863//26404942 chr21:34809174-34809175(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr21:34809180-34809181(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr21:34809207-34809208(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr21:34809269-34809270(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22608085 chr21:34809342-34809343(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr21:34809353-34809354(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr21:34809397-34809398(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr21:34809406-34809407(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr21:34809520-34809521(+) m6A 3'UTR//intron       24284625//22608085 chr21:34809613-34809614(+) m6A 3'UTR//intron       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	IFNGR2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: IFNGR2

Evidence Support:

Strong-Evidence	Luciferase reporter assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).