Basic Information:

  VIRBase ID:  

VHID00277208

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          GPD2:  NM_001083112     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	GPD2
miRBase Accession/Entrez ID	MIMAT0000995	2820
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GDH2//GPDM//mGDH//mGPDH

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GPD2	chr2:157348382(+) A-I      intronic chr2:157317920(+) A-I      intronic chr2:157299252(+) A-I      intronic chr2:157299231(+) A-I      intronic chr2:157348367(+) A-I      intronic chr2:157348370(+) A-I      intronic chr2:157318106(+) A-I      intronic chr2:157348381(+) A-I      intronic chr2:157348385(+) A-I      intronic chr2:157348389(+) A-I      intronic chr2:157317924(+) A-I      intronic chr2:157304762(+) A-I      intronic chr2:157321975(+) A-I      intronic chr2:157304819(+) A-I      intronic chr2:157301104(+) A-I      intronic chr2:157310274(+) A-I      intronic chr2:157301397(+) A-I      intronic chr2:157373171(+) A-I      intronic chr2:157373140(+) A-I      intronic chr2:157373002(+) A-I      intronic chr2:157371753(+) A-I      intronic chr2:157371684(+) A-I      intronic chr2:157371670(+) A-I      intronic chr2:157348805(+) A-I      intronic chr2:157310278(+) A-I      intronic chr2:157348315(+) A-I      intronic chr2:157341293(+) A-I      intronic chr2:157341256(+) A-I      intronic chr2:157341202(+) A-I      intronic chr2:157341192(+) A-I      intronic chr2:157341175(+) A-I      intronic chr2:157341173(+) A-I      intronic chr2:157341153(+) A-I      intronic chr2:157340822(+) A-I      intronic chr2:157340751(+) A-I      intronic chr2:157340747(+) A-I      intronic chr2:157340727(+) A-I      intronic chr2:157321991(+) A-I      intronic chr2:157337346(+) A-I      intronic chr2:157321986(+) A-I      intronic chr2:157333766(+) A-I      intronic chr2:157333709(+) A-I      intronic chr2:157331940(+) A-I      intronic chr2:157296082(+) A-I      intronic chr2:157296092(+) A-I      intronic chr2:157297802(+) A-I      intronic chr2:157297833(+) A-I      intronic chr2:157301282(+) A-I      intronic chr2:157297950(+) A-I      intronic chr2:157301046(+) A-I      intronic chr2:157304701(+) A-I      intronic chr2:157304759(+) A-I      intronic chr2:157301047(+) A-I      intronic chr2:157310295(+) A-I      intronic chr2:157310298(+) A-I      intronic chr2:157310334(+) A-I      intronic chr2:157316079(+) A-I      intronic chr2:157322106(+) A-I      intronic chr2:157322035(+) A-I      intronic chr2:157348434(+) A-I      intronic chr2:157295834(+) A-I      intronic chr2:157341074(+) A-I      intronic chr2:157371793(+) A-I      intronic chr2:157348783(+) A-I      intronic chr2:157304720(+) A-I      intronic chr2:157348380(+) A-I      intronic chr2:157341102(+) A-I      intronic chr2:157348766(+) A-I      intronic chr2:157301210(+) A-I      intronic chr2:157373120(+) A-I      intronic chr2:157316020(+) A-I      intronic chr2:157340911(+) A-I      intronic chr2:157322013(+) A-I      intronic chr2:157296200(+) A-I      intronic chr2:157371692(+) A-I      intronic chr2:157371848(+) A-I      intronic chr2:157333872(+) A-I      intronic chr2:157341194(+) A-I      intronic chr2:157301380(+) A-I      intronic chr2:157340832(+) A-I      intronic chr2:157341302(+) A-I      intronic chr2:157316053(+) A-I      intronic chr2:157331509(+) A-I      intronic chr2:157301110(+) A-I      intronic chr2:157371721(+) A-I      intronic chr2:157341205(+) A-I      intronic chr2:157316121(+) A-I      intronic chr2:157316048(+) A-I      intronic chr2:157316042(+) A-I      intronic chr2:157302677(+) A-I      intronic chr2:157340765(+) A-I      intronic chr2:157371755(+) A-I      intronic chr2:157303983(+) A-I      intronic chr2:157315943(+) A-I      intronic chr2:157373009(+) A-I      intronic chr2:157299162(+) A-I      intronic chr2:157348778(+) A-I      intronic chr2:157371751(+) A-I      intronic chr2:157371683(+) A-I      intronic chr2:157322107(+) A-I      intronic chr2:157341196(+) A-I      intronic chr2:157295812(+) A-I      intronic chr2:157341190(+) A-I      intronic chr2:157296183(+) A-I      intronic chr2:157348318(+) A-I      intronic chr2:157316041(+) A-I      intronic chr2:157337408(+) A-I      intronic chr2:157340746(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GPD2	chr2:157371848(+) A-I intron -    21960545 chr2:157440856(+) T-G intron -    21725310 chr2:157296361(+) A-T intron -    22484847 chr2:157301110(+) A-G intron -    22484847 chr2:157303266(+) A-G intron -    22484847 chr2:157303983(+) A-G intron -    22484847 chr2:157304720(+) A-G intron -    22484847 chr2:157304721(+) A-G intron -    22484847 chr2:157322013(+) A-G intron -    22484847 chr2:157333872(+) A-G intron -    22484847 chr2:157337371(+) A-G intron -    22484847 chr2:157337390(+) A-G intron -    22484847 chr2:157337391(+) A-G intron -    22484847 chr2:157337408(+) A-G intron -    22484847 chr2:157341074(+) A-G intron -    22484847 chr2:157341102(+) A-G intron -    22484847 chr2:157341190(+) A-G intron -    22484847 chr2:157341194(+) A-G intron -    22484847 chr2:157341196(+) A-G intron -    22484847 chr2:157341199(+) A-G intron -    22484847 chr2:157341205(+) A-G intron -    22484847 chr2:157341229(+) A-G intron -    22484847 chr2:157341254(+) A-G intron -    22484847 chr2:157341272(+) A-G intron -    22484847 chr2:157341273(+) A-G intron -    22484847 chr2:157341302(+) A-G intron -    22484847 chr2:157341336(+) A-G intron -    22484847 chr2:157348778(+) A-G intron -    22484847 chr2:157348783(+) A-G intron -    22484847 chr2:157348831(+) A-G intron -    22484847 chr2:157363544(+) G-T intron -    22484847 chr2:157371683(+) A-G intron -    22484847 chr2:157371751(+) A-G intron -    22484847 chr2:157371793(+) A-G intron -    22484847 chr2:157433971(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GPD2	chr2:157292227-157292228(+) m6A 5'UTR//intron       24981863 chr2:157292298-157292299(+) m6A 5'UTR//intron       24981863 chr2:157292976-157292977(+) m6A 5'UTR//exon//intron       24981863 chr2:157427761-157427762(+) m6A CDS//exon//intron       - chr2:157427776-157427777(+) m6A CDS//exon//intron       - chr2:157439364-157439365(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr2:157439377-157439378(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr2:157439407-157439408(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr2:157439458-157439459(+) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27773535//22608085 chr2:157439503-157439504(+) m6A 3'UTR//exon//intron       24284625//24981863//26404942 chr2:157439553-157439554(+) m6A 3'UTR//exon//intron       24981863//26404942 chr2:157442628-157442629(+) m6A 3'UTR//intron       27773535 chr2:157442650-157442651(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	GPD2	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: GPD2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).