Basic Information:

  VIRBase ID:  

VHID00277073

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          CPD:  NM_001304     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	CPD
miRBase Accession/Entrez ID	MIMAT0000995	1362
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GP180

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CPD	chr17:28777179(+) A-I      intronic chr17:28777211(+) A-I      intronic chr17:28724676(+) A-I      intronic chr17:28724635(+) A-I      intronic chr17:28724598(+) A-I      intronic chr17:28777174(+) A-I      intronic chr17:28777178(+) A-I      intronic chr17:28777175(+) A-I      intronic chr17:28746579(+) A-I      intronic chr17:28717164(+) A-I      intronic chr17:28772340(+) A-I      intronic chr17:28717115(+) A-I      intronic chr17:28717134(+) A-I      intronic chr17:28717152(+) A-I      intronic chr17:28743198(+) A-I      intronic chr17:28746573(+) A-I      intronic chr17:28746458(+) A-I      intronic chr17:28746457(+) A-I      intronic chr17:28745340(+) A-I      intronic chr17:28745302(+) A-I      intronic chr17:28724658(+) A-I      intronic chr17:28724962(+) A-I      intronic chr17:28724742(+) A-I      intronic chr17:28724689(+) A-I      intronic chr17:28772363(+) A-I      intronic chr17:28724649(+) A-I      intronic chr17:28724606(+) A-I      intronic chr17:28724603(+) A-I      intronic chr17:28724567(+) A-I      intronic chr17:28720930(+) A-I      intronic chr17:28743164(+) A-I      intronic chr17:28727907(+) A-I      intronic chr17:28772372(+) A-I      intronic chr17:28727902(+) A-I      intronic chr17:28726931(+) A-I      intronic chr17:28772376(+) A-I      intronic chr17:28772389(+) A-I      intronic chr17:28777155(+) A-I      intronic chr17:28777667(+) A-I      intronic chr17:28777685(+) A-I      intronic chr17:28717109(+) A-I      intronic chr17:28777778(+) A-I      intronic chr17:28772362(+) A-I      intronic chr17:28777216(+) A-I      intronic chr17:28777249(+) A-I      intronic chr17:28726779(+) A-I      intronic chr17:28724986(+) A-I      intronic chr17:28717099(+) A-I      intronic chr17:28713087(+) A-I      intronic chr17:28720904(+) A-I      intronic chr17:28724671(+) A-I      intronic chr17:28777780(+) A-I      intronic chr17:28720903(+) A-I      intronic chr17:28718400(+) A-I      intronic chr17:28764980(+) A-I      intronic chr17:28764516(+) A-I      intronic chr17:28745527(+) A-I      intronic chr17:28724569(+) A-I      intronic chr17:28718402(+) A-I      intronic chr17:28719092(+) A-I      intronic chr17:28725014(+) A-I      intronic chr17:28764447(+) A-I      intronic chr17:28724541(+) A-I      intronic chr17:28764959(+) A-I      intronic chr17:28713106(+) A-I      intronic chr17:28724954(+) A-I      intronic chr17:28713079(+) A-I      intronic chr17:28721032(+) A-I      intronic chr17:28784787(+) A-I      intronic chr17:28777352(+) A-I      intronic chr17:28771642(+) A-I      intronic chr17:28784697(+) A-I      intronic chr17:28724710(+) A-I      intronic chr17:28771566(+) A-I      intronic chr17:28725012(+) A-I      intronic chr17:28713300(+) A-I      intronic chr17:28718338(+) A-I      intronic chr17:28724645(+) A-I      intronic chr17:28777797(+) A-I      intronic chr17:28726980(+) A-I      intronic chr17:28785118(+) A-I      intronic chr17:28724600(+) A-I      intronic chr17:28777240(+) A-I      intronic chr17:28724609(+) A-I      intronic chr17:28772478(+) A-I      intronic chr17:28784788(+) A-I      intronic chr17:28727745(+) A-I      intronic chr17:28771579(+) A-I      intronic chr17:28728766(+) A-I      intronic chr17:28726926(+) A-I      intronic chr17:28720897(+) A-I      intronic chr17:28730013(+) A-I      intronic chr17:28783762(+) A-I      intronic chr17:28752563(+) A-I      intronic chr17:28724657(+) A-I      intronic chr17:28724963(+) A-I      intronic chr17:28752664(+) A-I      intronic chr17:28764618(+) A-I      intronic chr17:28775940(+) A-I      intronic chr17:28779496(+) A-I      intronic chr17:28785114(+) A-I      intronic chr17:28777657(+) A-I      intronic chr17:28726988(+) A-I      intronic chr17:28720909(+) A-I      intronic chr17:28784796(+) A-I      intronic chr17:28724493(+) A-I      intronic chr17:28717269(+) A-I      intronic chr17:28755581(+) A-I      intronic chr17:28785736(+) A-I      intronic chr17:28764580(+) A-I      intronic chr17:28764623(+) A-I      intronic chr17:28717270(+) A-I      intronic chr17:28777792(+) A-I      intronic chr17:28785141(+) A-I      intronic chr17:28713282(+) A-I      intronic chr17:28729473(+) A-I      intronic chr17:28728627(+) A-I      intronic chr17:28784869(+) A-I      intronic chr17:28777757(+) A-I      intronic chr17:28717282(+) A-I      intronic chr17:28757294(+) A-I      intronic chr17:28721042(+) A-I      intronic chr17:28724605(+) A-I      intronic chr17:28755478(+) A-I      intronic chr17:28777701(+) A-I      intronic chr17:28777718(+) A-I      intronic chr17:28757367(+) A-I      intronic chr17:28765064(+) A-I      intronic chr17:28726948(+) A-I      intronic chr17:28724601(+) A-I      intronic chr17:28764441(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CPD	chr17:28706488-28706489(+) m6A CDS       - chr17:28749733-28749734(+) m6A CDS       24284625//22608085 chr17:28749848-28749849(+) m6A CDS       24284625//24981863//26404942//22608085 chr17:28749882-28749883(+) m6A CDS       24284625//24981863//26404942//22608085 chr17:28749994-28749995(+) m6A CDS       26404942//22608085 chr17:28754435-28754436(+) m6A CDS       27773535 chr17:28754459-28754460(+) m6A CDS       27773535 chr17:28754474-28754475(+) m6A CDS       27773535 chr17:28788987-28788988(+) m6A CDS//intron       26404942 chr17:28791675-28791676(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:28791790-28791791(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:28791808-28791809(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:28791825-28791826(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:28791835-28791836(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:28791895-28791896(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:28791915-28791916(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:28791995-28791996(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr17:28792020-28792021(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr17:28792059-28792060(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr17:28792796-28792797(+) m6A 3'UTR//intron       24284625 chr17:28792827-28792828(+) m6A 3'UTR//intron       24284625//26404942 chr17:28793071-28793072(+) m6A 3'UTR//intron       26404942 chr17:28793896-28793897(+) m6A 3'UTR       24284625//24981863//22608085 chr17:28793937-28793938(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr17:28793971-28793972(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr17:28793999-28794000(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085 chr17:28794004-28794005(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085 chr17:28794061-28794062(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr17:28794067-28794068(+) Y 3'UTR       26075521 chr17:28794475-28794476(+) m6A 3'UTR       24981863 chr17:28794549-28794550(+) m6A 3'UTR       24981863 chr17:28794573-28794574(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	CPD	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: CPD

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).