Basic Information:

  VIRBase ID:  

VHID00277062

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          AP1S1:  NM_001283     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	AP1S1
miRBase Accession/Entrez ID	MIMAT0000995	1174
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AP19//CLAPS1//EKV3//MEDNIK//SIGMA1A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AP1S1	chr7:100799329(+) A-I      intronic chr7:100801905(+) A-I      intronic chr7:100802050(+) A-I      intronic chr7:100801132(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AP1S1	chr7:100797744-100797745(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr7:100797884-100797885(+) m6A CDS//intron       24284625//24981863 chr7:100799909-100799910(+) m6A CDS       - chr7:100799944-100799945(+) m6A CDS       - chr7:100799958-100799959(+) Am CDS       - chr7:100799958-100799959(+) m1A CDS       26863196 chr7:100800698-100800699(+) m6A CDS       26404942 chr7:100800749-100800750(+) m6A CDS       26404942 chr7:100802352-100802353(+) m6A CDS       26404942 chr7:100803937-100803938(+) m6A 3'UTR       24284625 chr7:100804127-100804128(+) m6A 3'UTR//intron       26404942 chr7:100804351-100804352(+) m6A 3'UTR//intron       - chr7:100804426-100804427(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	AP1S1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: AP1S1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).