Detail Information

Basic Information:


  VIRBase ID:  

VHID00276986

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           AKT2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 AKT2
miRBase
Accession/Entrez ID		 MIMAT0000995 208
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - HIHGHH//PKBB//PKBBETA//PRKBB//RAC-BETA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR AKT2
chr19:40782405(-) A-I      intronic
chr19:40782442(-) A-I      intronic
chr19:40782441(-) A-I      intronic
chr19:40736767(-) A-I      3'UTR
chr19:40736743(-) A-I      3'UTR
chr19:40736798(-) A-I      3'UTR
chr19:40736802(-) A-I      3'UTR
chr19:40736806(-) A-I      3'UTR
chr19:40782637(-) A-I      intronic
chr19:40782379(-) A-I      intronic
chr19:40788573(-) A-I      intronic
chr19:40782370(-) A-I      intronic
chr19:40782443(-) A-I      intronic
chr19:40782448(-) A-I      intronic
chr19:40782388(-) A-I      intronic
chr19:40782449(-) A-I      intronic
chr19:40782401(-) A-I      intronic
chr19:40782892(-) A-I      intronic
chr19:40782818(-) A-I      intronic
chr19:40782535(-) A-I      intronic
chr19:40782477(-) A-I      intronic
chr19:40782924(-) A-I      intronic
chr19:40782518(-) A-I      intronic
chr19:40781837(-) A-I      intronic
chr19:40782802(-) A-I      intronic
chr19:40782486(-) A-I      intronic
chr19:40782450(-) A-I      intronic
chr19:40746838(-) A-I      intronic
chr19:40782378(-) A-I      intronic
chr19:40746832(-) A-I      intronic
chr19:40760327(-) A-I      intronic
chr19:40782361(-) A-I      intronic
chr19:40782904(-) A-I      intronic
chr19:40760323(-) A-I      intronic
chr19:40781647(-) A-I      intronic
chr19:40781856(-) A-I      intronic
chr19:40781771(-) A-I      intronic
chr19:40760260(-) A-I      intronic
chr19:40736695(-) A-I      3'UTR
chr19:40736809(-) A-I      3'UTR
chr19:40736893(-) A-I      3'UTR
chr19:40736897(-) A-I      3'UTR
chr19:40782718(-) A-I      intronic
chr19:40782886(-) A-I      intronic
chr19:40752236(-) A-I      intronic
chr19:40781820(-) A-I      intronic
chr19:40777271(-) A-I      intronic
chr19:40782358(-) A-I      intronic
chr19:40782880(-) A-I      intronic
chr19:40782678(-) A-I      intronic
chr19:40772847(-) A-I      intronic
chr19:40752152(-) A-I      intronic
chr19:40782808(-) A-I      intronic
chr19:40750239(-) A-I      intronic
chr19:40742713(-) A-I      intronic
chr19:40774960(-) A-I      intronic
chr19:40782451(-) A-I      intronic
chr19:40782437(-) A-I      intronic
chr19:40787304(-) A-I      intronic
chr19:40782562(-) A-I      intronic
chr19:40752226(-) A-I      intronic
chr19:40746848(-) A-I      intronic
chr19:40781836(-) A-I      intronic
chr19:40752304(-) A-I      intronic
chr19:40782500(-) A-I      intronic
chr19:40736902(-) A-I      3'UTR
chr19:40736797(-) A-I      3'UTR
chr19:40782544(-) A-I      intronic
chr19:40782476(-) A-I      intronic
chr19:40782830(-) A-I      intronic
chr19:40736766(-) A-I      3'UTR
chr19:40782550(-) A-I      intronic
chr19:40782657(-) A-I      intronic
chr19:40756206(-) A-I      intronic
chr19:40782908(-) A-I      intronic
chr19:40736811(-) A-I      3'UTR
chr19:40782928(-) A-I      intronic
chr19:40782666(-) A-I      intronic
chr19:40782725(-) A-I      intronic
chr19:40736808(-) A-I      3'UTR
chr19:40787330(-) A-I      intronic
chr19:40736831(-) A-I      3'UTR
chr19:40782552(-) A-I      intronic
chr19:40777215(-) A-I      intronic
chr19:40736730(-) A-I      3'UTR
chr19:40781649(-) A-I      intronic
chr19:40774951(-) A-I      intronic
chr19:40736749(-) A-I      3'UTR
chr19:40787201(-) A-I      intronic
chr19:40781728(-) A-I      intronic
chr19:40736903(-) A-I      3'UTR
chr19:40781859(-) A-I      intronic
chr19:40756248(-) A-I      intronic
chr19:40756374(-) A-I      intronic
chr19:40782896(-) A-I      intronic
chr19:40782340(-) A-I      intronic
chr19:40742818(-) A-I      intronic
chr19:40782333(-) A-I      intronic
chr19:40774861(-) A-I      intronic
chr19:40781740(-) A-I      intronic
chr19:40782756(-) A-I      intronic
chr19:40778994(-) A-I      intronic
chr19:40782446(-) A-I      intronic
chr19:40742831(-) A-I      intronic
chr19:40782648(-) A-I      intronic
chr19:40760709(-) A-I      intronic
chr19:40782731(-) A-I      intronic
chr19:40782452(-) A-I      intronic
chr19:40782679(-) A-I      intronic
chr19:40776868(-) A-I      intronic
chr19:40746815(-) A-I      intronic
chr19:40782410(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED AKT2
chr19:40736725(-) A-G exon 3'UTR    22484847
chr19:40782410(-) A-G intron -    22484847
chr19:40782413(-) A-G intron -    22484847
chr19:40782437(-) A-G intron -    22484847
chr19:40782446(-) A-G intron -    22484847
chr19:40782476(-) A-G intron -    22484847
chr19:40782492(-) A-G intron -    22484847
chr19:40782550(-) A-G intron -    22484847
chr19:40782688(-) A-G intron -    22484847
chr19:40782725(-) A-G intron -    22484847
chr19:40782830(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AKT2
chr19:40737702-40737703(-) Y 3'UTR       26075521
chr19:40737942-40737943(-) m6A 3'UTR       24981863
chr19:40737993-40737994(-) m6A 3'UTR       -
chr19:40737999-40738000(-) m6A 3'UTR       -
chr19:40738174-40738175(-) m6A 3'UTR       -
chr19:40738240-40738241(-) m6A 3'UTR       27773535
chr19:40738253-40738254(-) m6A 3'UTR//exon       27773535
chr19:40738679-40738680(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr19:40738698-40738699(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr19:40738730-40738731(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr19:40738864-40738865(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//22608085
chr19:40738883-40738884(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//22608085
chr19:40738987-40738988(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//22575960//22608085
chr19:40739053-40739054(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:40739067-40739068(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085
chr19:40739099-40739100(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:40739153-40739154(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr19:40739359-40739360(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22575960
chr19:40739555-40739556(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:40739570-40739571(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:40739822-40739823(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr19:40739830-40739831(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr19:40740379-40740380(-) m6A 3'UTR//intron       24284625//27773535
chr19:40741036-40741037(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536
chr19:40743095-40743096(-) m6A exon//intron       -
chr19:40743122-40743123(-) m6A exon//intron       -
chr19:40743144-40743145(-) m6A exon//intron       -
chr19:40743188-40743189(-) m6A exon//intron       -
chr19:40744858-40744859(-) m6A 3'UTR//CDS//exon//intron       27773535
chr19:40745211-40745212(-) m6A exon//intron       -
chr19:40745292-40745293(-) m6A exon//intron       -
chr19:40745324-40745325(-) m6A exon//intron       -
chr19:40745973-40745974(-) m6A 3'UTR//CDS//exon//intron       27371828//27773536
chr19:40746720-40746721(-) m6A exon//intron       27371828//27773536
chr19:40747933-40747934(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr19:40747949-40747950(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr19:40747975-40747976(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr19:40748519-40748520(-) m6A 3'UTR//CDS//exon       24284625//26404942//27371828//27773536
chr19:40748528-40748529(-) m6A 3'UTR//CDS//exon       24284625//26404942//27371828//27773536
chr19:40748615-40748616(-) m6A exon//intron       24284625//27371828//27773536
chr19:40748631-40748632(-) m6A exon//intron       24284625//27371828//27773536
chr19:40761092-40761093(-) m6A CDS//exon       24284625//24981863
chr19:40761110-40761111(-) m6A CDS//exon       24284625//24981863//27773535
chr19:40761158-40761159(-) m6A CDS//exon       24284625//24981863//27773535
chr19:40762849-40762850(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr19:40762865-40762866(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr19:40762946-40762947(-) m6A 5'UTR//CDS//exon       27773535
chr19:40785096-40785097(-) m6A 5'UTR//exon//intron       27773536
chr19:40785123-40785124(-) m6A 5'UTR//exon//intron       27773536
chr19:40785184-40785185(-) m6A 5'UTR//exon//intron       27773536
chr19:40785253-40785254(-) m6A 5'UTR//intron       27773536
chr19:40785269-40785270(-) m6A 5'UTR//intron       27773536
chr19:40785306-40785307(-) m6A 5'UTR//intron       27773536
chr19:40785423-40785424(-) m6A 5'UTR//intron       27773536
chr19:40785447-40785448(-) m6A 5'UTR//intron       27773536
chr19:40790803-40790804(-) m6A 5'UTR//intron       25456834//24981863//27773536
chr19:40790983-40790984(-) m6A 5'UTR//intron       24209618//27773536
chr19:40791154-40791155(-) m6A 5'UTR//intron       24209618//24981863
chr19:40791169-40791170(-) m6A 5'UTR//intron       24209618//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
AKT2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: AKT2

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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