Basic Information:

  VIRBase ID:  

VHID00276943

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   RBM14:  NP_001185766     

Interactor Information:

	Interactor1	Interactor2
Symbol	EBER2	RBM14
miRBase Accession/Entrez ID	EBER2	10432
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	lncRNA	protein
Alias	-	COAA//PSP2//SIP//SYTIP1//TMEM137

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RBM14	chr11:66389486(+) A-I      intronic chr11:66397338(+) A-I      3'UTR chr11:66397387(+) A-I      3'UTR chr11:66389846(+) A-I      intronic chr11:66389834(+) A-I      intronic chr11:66389894(+) A-I      intronic chr11:66397362(+) A-I      3'UTR chr11:66397364(+) A-I      3'UTR chr11:66397319(+) A-I      3'UTR chr11:66396911(+) A-I      3'UTR chr11:66397372(+) A-I      3'UTR chr11:66397370(+) A-I      3'UTR chr11:66397320(+) A-I      3'UTR chr11:66397278(+) A-I      3'UTR chr11:66397285(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RBM14	chr11:66384113-66384114(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:66384295-66384296(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:66384472-66384473(+) m6A CDS//exon       24284625//24209618//22575960//22608085 chr11:66384707-66384708(+) m6A exon//intron       24284625//24209618//22608085 chr11:66391781-66391782(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:66391834-66391835(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:66391839-66391840(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:66391847-66391848(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:66391878-66391879(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:66392133-66392134(+) m6A CDS//intron       24284625//24981863//22575960 chr11:66392419-66392420(+) Y CDS//intron       26075521 chr11:66394615-66394616(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr11:66394624-66394625(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr11:66394641-66394642(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:66394748-66394749(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:66394776-66394777(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EBER2	EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043 EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
	RBM14	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: EBER2
Interactor2: RBM14

Evidence Support:

Strong-Evidence	IP//Northern blot//qRT-PCR
Support Database	ViRBase

References:

PMID	26951683	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BJAB-B1 cells//HEK293T cells	Interactor2 expression	None
Description	Taken together, these results argue that SFPQ and RBM14 make direct contacts with EBER2, whereas SFPQ and NONO interact specifically with PAX5 (Fig.4D).