Detail Information

Basic Information:


  VIRBase ID:  

VHID00276933

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol EBER2 PDE3A
miRBase
Accession/Entrez ID		 EBER2 5139
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category lncRNA mRNA
Alias - CGI-PDE//CGI-PDE A//CGI-PDE-A//HTNB

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PDE3A
chr12:20760194(+) A-I      intronic
chr12:20760191(+) A-I      intronic
chr12:20760189(+) A-I      intronic
chr12:20760188(+) A-I      intronic
chr12:20760171(+) A-I      intronic
chr12:20643888(+) A-I      intronic
chr12:20643853(+) A-I      intronic
chr12:20643843(+) A-I      intronic
chr12:20643838(+) A-I      intronic
chr12:20640557(+) A-I      intronic
chr12:20640552(+) A-I      intronic
chr12:20636202(+) A-I      intronic
chr12:20636167(+) A-I      intronic
chr12:20640537(+) A-I      intronic
chr12:20558888(+) A-I      intronic
chr12:20559107(+) A-I      intronic
chr12:20640536(+) A-I      intronic
chr12:20640532(+) A-I      intronic
chr12:20640522(+) A-I      intronic
chr12:20615836(+) A-I      intronic
chr12:20615824(+) A-I      intronic
chr12:20615803(+) A-I      intronic
chr12:20615274(+) A-I      intronic
chr12:20604417(+) A-I      intronic
chr12:20640521(+) A-I      intronic
chr12:20640508(+) A-I      intronic
chr12:20640402(+) A-I      intronic
chr12:20640373(+) A-I      intronic
chr12:20639648(+) A-I      intronic
chr12:20639642(+) A-I      intronic
chr12:20639638(+) A-I      intronic
chr12:20639637(+) A-I      intronic
chr12:20695564(+) A-I      intronic
chr12:20640547(+) A-I      intronic
chr12:20636136(+) A-I      intronic
chr12:20537698(+) A-I      intronic
chr12:20537699(+) A-I      intronic
chr12:20537704(+) A-I      intronic
chr12:20537746(+) A-I      intronic
chr12:20537752(+) A-I      intronic
chr12:20537909(+) A-I      intronic
chr12:20538011(+) A-I      intronic
chr12:20538070(+) A-I      intronic
chr12:20545635(+) A-I      intronic
chr12:20545684(+) A-I      intronic
chr12:20538033(+) A-I      intronic
chr12:20639753(+) A-I      intronic
chr12:20639685(+) A-I      intronic
chr12:20636165(+) A-I      intronic
chr12:20636164(+) A-I      intronic
chr12:20636146(+) A-I      intronic
chr12:20636170(+) A-I      intronic
chr12:20741961(+) A-I      intronic
chr12:20714034(+) A-I      intronic
chr12:20636176(+) A-I      intronic
chr12:20636212(+) A-I      intronic
chr12:20714033(+) A-I      intronic
chr12:20677946(+) A-I      intronic
chr12:20677945(+) A-I      intronic
chr12:20645137(+) A-I      intronic
chr12:20645135(+) A-I      intronic
chr12:20760202(+) A-I      intronic
chr12:20639829(+) A-I      intronic
chr12:20636056(+) A-I      intronic
chr12:20636108(+) A-I      intronic
chr12:20615321(+) A-I      intronic
chr12:20580885(+) A-I      intronic
chr12:20580884(+) A-I      intronic
chr12:20615331(+) A-I      intronic
chr12:20615334(+) A-I      intronic
chr12:20615871(+) A-I      intronic
chr12:20618419(+) A-I      intronic
chr12:20618438(+) A-I      intronic
chr12:20618444(+) A-I      intronic
chr12:20618448(+) A-I      intronic
chr12:20618581(+) A-I      intronic
chr12:20620685(+) A-I      intronic
chr12:20620746(+) A-I      intronic
chr12:20620748(+) A-I      intronic
chr12:20620749(+) A-I      intronic
chr12:20643855(+) A-I      intronic
chr12:20639789(+) A-I      intronic
chr12:20639672(+) A-I      intronic
chr12:20643857(+) A-I      intronic
chr12:20640378(+) A-I      intronic
chr12:20645095(+) A-I      intronic
chr12:20713941(+) A-I      intronic
chr12:20640334(+) A-I      intronic
chr12:20620683(+) A-I      intronic
chr12:20640343(+) A-I      intronic
chr12:20713942(+) A-I      intronic
chr12:20714052(+) A-I      intronic
chr12:20714074(+) A-I      intronic
chr12:20639607(+) A-I      intronic
chr12:20740235(+) A-I      intronic
chr12:20640348(+) A-I      intronic
chr12:20639671(+) A-I      intronic
chr12:20640507(+) A-I      intronic
chr12:20640369(+) A-I      intronic
chr12:20641749(+) A-I      intronic
chr12:20641766(+) A-I      intronic
chr12:20639777(+) A-I      intronic
chr12:20639661(+) A-I      intronic
chr12:20639765(+) A-I      intronic
chr12:20620762(+) A-I      intronic
chr12:20641767(+) A-I      intronic
chr12:20640375(+) A-I      intronic
chr12:20641778(+) A-I      intronic
chr12:20759537(+) A-I      intronic
chr12:20640519(+) A-I      intronic
chr12:20640422(+) A-I      intronic
chr12:20615968(+) A-I      intronic
chr12:20641689(+) A-I      intronic
chr12:20620637(+) A-I      intronic
chr12:20615260(+) A-I      intronic
chr12:20640512(+) A-I      intronic
chr12:20640567(+) A-I      intronic
chr12:20740215(+) A-I      intronic
chr12:20615263(+) A-I      intronic
chr12:20639668(+) A-I      intronic
chr12:20640412(+) A-I      intronic
chr12:20640397(+) A-I      intronic
chr12:20653721(+) A-I      intronic
chr12:20640389(+) A-I      intronic
chr12:20615926(+) A-I      intronic
chr12:20640499(+) A-I      intronic
chr12:20640566(+) A-I      intronic
chr12:20618474(+) A-I      intronic
chr12:20640359(+) A-I      intronic
chr12:20615169(+) A-I      intronic
chr12:20538066(+) A-I      intronic
chr12:20615170(+) A-I      intronic
chr12:20644934(+) A-I      intronic
chr12:20759535(+) A-I      intronic
chr12:20639803(+) A-I      intronic
chr12:20742650(+) A-I      intronic
chr12:20768843(+) A-I      intronic
chr12:20628596(+) A-I      intronic
chr12:20643914(+) A-I      intronic
chr12:20634750(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PDE3A
chr12:20705228(+) A-I intron -    22327324
chr12:20704512(+) G-T intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PDE3A
chr12:20522252-20522253(+) m6A CDS       24284625//25456834//24981863//22575960
chr12:20522300-20522301(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr12:20522318-20522319(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr12:20522336-20522337(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr12:20522363-20522364(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr12:20522397-20522398(+) m6A CDS       24284625//25456834//24981863//22575960
chr12:20522884-20522885(+) m6A CDS       25456834//22575960
chr12:20522928-20522929(+) m6A CDS       22575960
chr12:20522985-20522986(+) m6A CDS       22575960
chr12:20523052-20523053(+) m6A CDS       22575960
chr12:20523148-20523149(+) m6A CDS//exon       22575960
chr12:20523174-20523175(+) m6A CDS//exon       22575960
chr12:20541270-20541271(+) Tm intron       -
chr12:20601012-20601013(+) Gm intron       -
chr12:20621743-20621744(+) Am intron       -
chr12:20704367-20704368(+) Um intron       16381836
chr12:20704405-20704406(+) Um intron       16381836
chr12:20704407-20704408(+) Gm intron       16381836
chr12:20704426-20704427(+) Y intron       16381836//25192136
chr12:20704446-20704447(+) Y intron       16381836//25192136
chr12:20704447-20704448(+) Y intron       16381836
chr12:20704462-20704463(+) Am intron       16381836
chr12:20704470-20704471(+) Cm intron       16381836
chr12:20704819-20704820(+) m6A intron       24284625
chr12:20704974-20704975(+) m6A intron       24284625
chr12:20705433-20705434(+) m6A intron       24981863
chr12:20705555-20705556(+) m6A intron       24284625//24209618//24981863
chr12:20705567-20705568(+) m6A intron       24284625//24209618//24981863
chr12:20705622-20705623(+) m6A intron       24284625
chr12:20705809-20705810(+) Cm intron       -
chr12:20706507-20706508(+) Y intron       26075521
chr12:20706508-20706509(+) Y intron       25219674
chr12:20769217-20769218(+) m6A CDS//exon       24284625
chr12:20769275-20769276(+) m6A CDS//exon       24284625
chr12:20769294-20769295(+) m6A CDS//exon       24284625
chr12:20786696-20786697(+) m6A CDS//exon       24981863
chr12:20786708-20786709(+) m6A CDS//exon       24981863
chr12:20787867-20787868(+) m6A CDS//exon       24981863
chr12:20807014-20807015(+) m6A CDS//exon       24284625//24981863//27773535
chr12:20807040-20807041(+) m6A CDS//exon       24284625//24981863//27773535
chr12:20807114-20807115(+) m6A CDS//exon       24284625//24981863//27773535//22575960
chr12:20832971-20832972(+) m6A CDS//exon       24284625//24981863//27773535//22575960
chr12:20833023-20833024(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960
chr12:20833092-20833093(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr12:20833097-20833098(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr12:20833120-20833121(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr12:20833162-20833163(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr12:20833197-20833198(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr12:20833233-20833234(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr12:20833252-20833253(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr12:20833280-20833281(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr12:20833380-20833381(+) m6A 3'UTR//exon       24284625//24981863
chr12:20833490-20833491(+) m6A 3'UTR       24981863
chr12:20833586-20833587(+) Y 3'UTR       25219674
chr12:20833812-20833813(+) m6A 3'UTR       22575960
chr12:20834112-20834113(+) m6A 3'UTR       24981863
chr12:20834121-20834122(+) m6A 3'UTR       24981863
chr12:20834164-20834165(+) m6A 3'UTR       24981863
chr12:20834238-20834239(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EBER2
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
PDE3A
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: EBER2
Interactor2: PDE3A

Evidence Support:


Strong-Evidence ChIP
Weak-Evidence RNA-Seq
Support Database ViRBase

References:


PMID 30176159 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line BJAB-B1 lymphoma cells Interactor2 expression None
Description Table 1.EBER2-interacting host RNAs. Gene ID, genome coordinates, and raw read count at maximum peak height are shown.

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