Detail Information

Basic Information:


  VIRBase ID:  

VHID00276929

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9933

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol EBER2 IGF1
miRBase
Accession/Entrez ID		 EBER2 3479
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category lncRNA mRNA
Alias - IGF//IGF-I//IGFI//MGF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IGF1
chr12:102837779(-) A-I      intronic
chr12:102837818(-) A-I      intronic
chr12:102837773(-) A-I      intronic
chr12:102837770(-) A-I      intronic
chr12:102837808(-) A-I      intronic
chr12:102800627(-) A-I      intronic
chr12:102800691(-) A-I      intronic
chr12:102800755(-) A-I      intronic
chr12:102800760(-) A-I      intronic
chr12:102800626(-) A-I      intronic
chr12:102797448(-) A-I      intronic
chr12:102835739(-) A-I      intronic
chr12:102800786(-) A-I      intronic
chr12:102798692(-) A-I      intronic
chr12:102798716(-) A-I      intronic
chr12:102797363(-) A-I      intronic
chr12:102798673(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IGF1
chr12:102797512(-) T-C intron -    22484847
chr12:102860443(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IGF1
chr12:102792923-102792924(-) m6A 3'UTR       27773535
chr12:102811374-102811375(-) m6A 3'UTR//intron       27773535
chr12:102811427-102811428(-) m6A 3'UTR//intron       27773535
chr12:102811544-102811545(-) m6A 3'UTR//intron       27773535
chr12:102811578-102811579(-) m6A 3'UTR//intron       27773535
chr12:102811591-102811592(-) m6A 3'UTR//intron       27773535
chr12:102811690-102811691(-) m6A CDS//intron       27773535
chr12:102811703-102811704(-) m6A CDS//intron       27773535
chr12:102811720-102811721(-) m6A CDS//intron       27773535
chr12:102811755-102811756(-) m6A CDS//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EBER2
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
IGF1
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: EBER2
Interactor2: IGF1

Evidence Support:


Strong-Evidence ELISA//Luciferase reporter assay//Northern blot//RT-PCR//Western blot
Support Database ViRBase

References:


[1]PMID 14612496 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line NU-GC-3 cells Interactor2 expression Downregulation
Description As shown in Fig.4B, the luciferase activity was significantly higher in EBER-expressing NU-GC-3 cells than in Neor-transfected NU-GC-3 cells. These results demonstrated that EBER activated transcription of the IGF-I gene.
[2]PMID 15608666 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line CNE1 cells//HONE1 cells Interactor2 expression Downregulation
Description Further studies demonstrated that increased IGF-1 expression reflected transcriptional activation, and EBV encoded small RNA (EBER) was responsible for IGF-1 induction.
[3]PMID 20399962 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line CNE1 cells//HONE1 cells Interactor2 expression Downregulation
Description Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2.

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