Detail Information

Basic Information:


  VIRBase ID:  

VHID00276927

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol EBER2 RPPH1
miRBase
Accession/Entrez ID		 EBER2 85495
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category lncRNA lncRNA
Alias - H1RNA//RPPH1-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 RPPH1
rs3093872 chr14:20343173 C/T         21829388

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RPPH1
chr14:20811248-20811249(-) m6A exon       26404942//27371828//27773536//22575960
chr14:20811267-20811268(-) m6A exon       25456834//26404942//27371828//27773536//22575960
chr14:20811324-20811325(-) m6A exon       25456834//26404942//27371828//27773536//22575960
chr14:20811377-20811378(-) m6A exon       25456834//26404942//27773535//27371828//27773536//22575960
chr14:20811392-20811393(-) m5C exon       23604283
chr14:20811398-20811399(-) m6A exon       25456834//26404942//27773535//27371828//27773536//22575960
chr14:20811482-20811483(-) Tm exon       -
chr14:20811484-20811485(-) m6A exon       25456834//26404942//27773535//27371828//27773536//22575960
chr14:20811582-20811583(-) m6A exon       26404942//27371828//27773536
chr14:20811733-20811734(-) m6A exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EBER2
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
RPPH1
Cytoplasm cHL cell lines (L1236|L428|L540)     27423697
Cytoplasm P493-6 cells     25690653
Cytosol HCC cell line (HepG2)     -
Exosome Breast cancer cell lines (MDA-MB-231|MDA-MB-436)     24255815
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug RPPH1
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tivozanib       9911830
Zibotentan       9910224
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
Osi-930       9868037
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
1,5-Diazabicyclo(3.2.1)octane, 8-(4-pyridyl)-       96625
Spermidine trihydrochloride       9539
8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577
1,9-Pyrazoloanthrone       8515
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-Yl)benzenesulfonamide       71271629
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Belinostat       6918638
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454
Temsirolimus       6918289
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
2-Chloro-3-(N-(L)-tyrosinamido)naphthazarin       6712245
AICA ribonucleotide       65110
Ispinesib mesylate       6450816
Axitinib       6450551
Cytarabine       6253
Gemcitabine       60750
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
Lfm-a13       54676905
Rubescensin A (Oridonin) [Rabdosia diterpenoid]       5459168
Trunculin A       5459125
Ajoene       5386591
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Bosutinib       5328940
Methyl 5-[2-(4-hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxylate       53239945
Vorinostat       5311
Imatinib       5291
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
Tubastatin A       49850262
Alectinib       49806720
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
Tretinoin       444795
Dabrafenib       44462760
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
Benzenediazonium, 4-(phenylamino)-, sulfate (2:1), polymer with formaldehyde       416926
4-N-(3-Bromophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine;methanesulfonic acid       382058
6-N-(4-Morpholino)-7-chloro-5,8-quinolinedione       379074
N'-(1-Nitroacridin-9-yl)propane-1,3-diamine       378853
2-Amino-5,8-dihydroxy-1,4-naphthoquinone       377209
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole       362897
2-(Benzylthio)malononitrile       361853
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane       355643
5-Fluorouracil       3385
Thymolphthalein       31316
Tamoxifen       2733526
Chelerythrine       2703
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Ruxolitinib       25126798
Cabozantinib       25102847
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Cudc-101       24756910
Diisopropoxybis(chinoline-8-olato)titanium(IV)       24202322
Vincaleukoblastine       241903
Methyl (1S,15S,16S,17S,21S)-17-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-18,23-dioxa-3,13-diazahexacyclo[13.7.1.01,13.02,10.04,9.016,21]tricosa-2(10),4,6,8,19-pentaene-20-carboxylate       21723831
Nutlin-3       216345
Lenalidomide       216326
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine       2051
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
Diallyl disulfide       16590
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Osi-027       135398516
Methotrexate       126941
Lestaurtinib       126565
Dactolisib       11977753
Veliparib       11960529
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Idelalisib       11625818
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide       11455910
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Amuvatinib       11282283
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
7-Ethyl-10-hydroxycamptothecin       104842
VX-702       10341154
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
PDK1 inhibitor AR-12       10027278
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion       -
1,3-isoquinolinedione, 4-[(3,4-dimethoxyphenyl)methylene]-       -
1-piperidinecarbodithioic acid, antimony complex       -
2,4-dimethoxy-6-(3'-fluorophenyl)-1,3,5-triazine       -
3-hydroxy-7-nitro-1,2,4-benzotriazine 1-oxide       -
3-methoxy-estra-1,3,5(10)-triene-(17,16-c)pyrazole       -
4-morpholinecarbodithioic acid, antimony complex       -
4-thiomorpholinecarbodithioic acid, antimony complex       -
antineoplastic-644916       -
chlorobisoximatobismuth(iii)-dihydrochloride       -
coc1ccc(cc1)c2nc(c=c3/sc(=nc3=o)ncc4ccccc4)c5ccccn25       -
Genentech Cpd 10       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
ptmc       -
QL-X-138       -
QL-XI-92       -
QL-XII-47       -
SB52334       -
THZ-2-102-1       -
THZ-2-49       -
TL-1-85       -
TL-2-105       -
VNLG/124       -
XMD13-2       -
XMD14-99       -
XMD15-27       -
;(Z)-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3...       -
;(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-tria...       -

Interaction Network (The top 100 interactions):


Interactor1: EBER2
Interactor2: RPPH1

Evidence Support:


Strong-Evidence ChIP
Weak-Evidence RNA-Seq
Support Database ViRBase

References:


PMID 30176159 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line BJAB-B1 lymphoma cells Interactor2 expression None
Description Table 1.EBER2-interacting host RNAs. Gene ID, genome coordinates, and raw read count at maximum peak height are shown.

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