Detail Information
Interactor1 | Interactor2 | |
---|---|---|
Symbol | EBER1 | TLR3 |
miRBase Accession/Entrez ID |
EBER1 | 7098 |
Organism | Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) | Homo sapiens |
Category | lncRNA | protein |
Alias | - | CD283//IIAE2 |
Resource | Symbol | Editing Position | Change | Genetic Region | ||||||
---|---|---|---|---|---|---|---|---|---|---|
RADAR | TLR3 |
|
Resource | Symbol | ModificationPosition | Type | Genomic Context | PMID | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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RMBase | TLR3 |
|
Resource | Symbol | Subcellular Localization | Tissue or Cell Line | PMID | ||
---|---|---|---|---|---|---|
RNALocate | EBER1 | |||||
TLR3 |
|
Interactor1: EBER1 | Interactor2: TLR3 |
---|
Strong-Evidence | Coimmunoprecipitation//RT-PCR | |
---|---|---|
Support Database | ViRBase |
[1]PMID | 19720839 | Target region | None |
---|---|---|---|
Source | ViRBase | Interactor1 expression | None |
Tissue or cell line | AGS cells//Akata cells//Mutu cells//NU-GC-3 cells | Interactor2 expression | None |
Description | To further assess whether EBER can activate TLR3 in complexes with La, we used immunoprecipitates from culture supernatants of EBV-positive or EBER-knockout EBV-infected cells for stimulation. |
[2]PMID | 20399962 | Target region | None |
---|---|---|---|
Source | ViRBase | Interactor1 expression | None |
Tissue or cell line | AGS cells//Akata cells//Mutu cells//NU-GC-3 cells | Interactor2 expression | None |
Description | Most recently, it was reported that EBERs are secreted from EBV-infected cells and are recognized by toll-like receptor (TLR)3, leading to induction of type-I IFNs and inflammatory cytokines, and subsequent immune activation. Furthermore, EBER1 could be detected in the sera of patients with active EBV infectious diseases, suggesting that activation of TLR3 signaling by EBER1 would be account for the pathogenesis of active EBV infectious diseases. |