Detail Information

Basic Information:


  VIRBase ID:  

VHID00276923

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   SSB:      

Interactor Information:


Interactor1 Interactor2
Symbol EBER1 SSB
miRBase
Accession/Entrez ID		 EBER1 6741
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category lncRNA protein
Alias - La//La/SSB//LARP3

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SSB
chr2:170665627(+) A-I      intronic
chr2:170660438(+) A-I      intronic
chr2:170660323(+) A-I      intronic
chr2:170666278(+) A-I      intronic
chr2:170666275(+) A-I      intronic
chr2:170666264(+) A-I      intronic
chr2:170665652(+) A-I      intronic
chr2:170665641(+) A-I      intronic
chr2:170665776(+) A-I      intronic
chr2:170665740(+) A-I      intronic
chr2:170665704(+) A-I      intronic
chr2:170665692(+) A-I      intronic
chr2:170666240(+) A-I      intronic
chr2:170656976(+) A-I      intronic
chr2:170666328(+) A-I      intronic
chr2:170661489(+) A-I      intronic
chr2:170661423(+) A-I      intronic
chr2:170661130(+) A-I      intronic
chr2:170661076(+) A-I      intronic
chr2:170659915(+) A-I      intronic
chr2:170665812(+) A-I      intronic
chr2:170665816(+) A-I      intronic
chr2:170666166(+) A-I      intronic
chr2:170665846(+) A-I      intronic
chr2:170665715(+) A-I      intronic
chr2:170665731(+) A-I      intronic
chr2:170660277(+) A-I      intronic
chr2:170659889(+) A-I      intronic
chr2:170661520(+) A-I      intronic
chr2:170666325(+) A-I      intronic
chr2:170660786(+) A-I      intronic
chr2:170661306(+) A-I      intronic
chr2:170660222(+) A-I      intronic
chr2:170665840(+) A-I      intronic
chr2:170661236(+) A-I      intronic
chr2:170666333(+) A-I      intronic
chr2:170666216(+) A-I      intronic
chr2:170665690(+) A-I      intronic
chr2:170661157(+) A-I      intronic
chr2:170660378(+) A-I      intronic
chr2:170659852(+) A-I      intronic
chr2:170660261(+) A-I      intronic
chr2:170656927(+) A-I      intronic
chr2:170661622(+) A-I      intronic
chr2:170660388(+) A-I      intronic
chr2:170661239(+) A-I      intronic
chr2:170665837(+) A-I      intronic
chr2:170660105(+) A-I      intronic
chr2:170665644(+) A-I      intronic
chr2:170656996(+) A-I      intronic
chr2:170661628(+) A-I      intronic
chr2:170665635(+) A-I      intronic
chr2:170664061(+) A-I      intronic
chr2:170658592(+) A-I      intronic
chr2:170661460(+) A-I      intronic
chr2:170660989(+) A-I      intronic
chr2:170665771(+) A-I      intronic
chr2:170661627(+) A-I      intronic
chr2:170661088(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SSB
chr2:170660105(+) A-G intron -    22484847
chr2:170661088(+) A-G intron -    22484847
chr2:170661157(+) A-G intron -    22484847
chr2:170661473(+) T-C intron -    22484847
chr2:170661520(+) A-G intron -    22484847
chr2:170661627(+) A-G intron -    22484847
chr2:170661628(+) A-G intron -    22484847
chr2:170665635(+) A-G intron -    22484847
chr2:170665838(+) C-A intron -    22484847
chr2:170666333(+) A-G intron -    22484847
chr2:170666400(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SSB
chr2:170655477-170655478(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863
chr2:170662014-170662015(+) m6A 5'UTR//CDS//exon       27773535
chr2:170662030-170662031(+) m6A 5'UTR//CDS//exon       27773535
chr2:170662039-170662040(+) m6A 5'UTR//CDS//exon       27773535
chr2:170662179-170662180(+) m6A CDS//exon       27773535
chr2:170662194-170662195(+) m6A CDS//exon       27773535
chr2:170662237-170662238(+) m6A CDS//exon       24981863//27773535
chr2:170662262-170662263(+) m6A CDS//exon       24981863//27773535
chr2:170662288-170662289(+) m6A CDS//exon       24981863//27773535
chr2:170662332-170662333(+) m6A CDS//exon       24981863//27773535
chr2:170663381-170663382(+) m6A 3'UTR//CDS//exon       27773535
chr2:170663416-170663417(+) m6A exon//intron       27773535
chr2:170663443-170663444(+) m6A exon//intron       27773535
chr2:170663534-170663535(+) m6A CDS//exon       27773535
chr2:170663558-170663559(+) m6A CDS//exon       24981863//27773535
chr2:170665027-170665028(+) m6A CDS//exon       24981863//27773535
chr2:170665060-170665061(+) m6A CDS//exon       24981863//27773535//22608085
chr2:170665076-170665077(+) m6A exon//intron       24981863//27773535//22608085
chr2:170665153-170665154(+) m6A exon//intron       24981863//27773535//22608085
chr2:170665174-170665175(+) m6A exon//intron       24981863//27773535//22608085
chr2:170665312-170665313(+) m6A exon//intron       24981863
chr2:170665384-170665385(+) m6A CDS//exon       24981863//27773535
chr2:170666581-170666582(+) m6A exon//intron       24981863//27773535
chr2:170666597-170666598(+) m6A exon//intron       24981863//27773535
chr2:170666669-170666670(+) m6A exon//intron       24981863//27773535
chr2:170666762-170666763(+) m6A exon//intron       24981863//27773535//22608085
chr2:170666852-170666853(+) m6A CDS//exon       24981863//27773535//22608085
chr2:170666910-170666911(+) m6A CDS//exon       24981863//27773535//22608085
chr2:170666984-170666985(+) m6A exon//intron       24981863//27773535//22608085
chr2:170666990-170666991(+) m6A exon//intron       24981863//27773535//22608085
chr2:170667449-170667450(+) m6A CDS//exon       24981863//27773535//22608085
chr2:170667518-170667519(+) m6A CDS//exon       24981863//27773535//22575960//22608085
chr2:170667536-170667537(+) m6A CDS//exon       24981863//27773535//22575960//22608085
chr2:170667801-170667802(+) m6A CDS       24981863//27773535//22575960//22608085
chr2:170667810-170667811(+) m6A CDS       24981863//27773535//22575960//22608085
chr2:170668203-170668204(+) m6A CDS       24981863//27773535//22575960//22608085
chr2:170668217-170668218(+) m6A CDS       24981863//27773535//22575960//22608085
chr2:170668229-170668230(+) m6A CDS       24981863//27773535//22575960//22608085
chr2:170668239-170668240(+) m6A CDS       24981863//27773535//22575960//22608085
chr2:170668258-170668259(+) m6A CDS       24981863//27773535//22575960
chr2:170668274-170668275(+) m6A 3'UTR       24981863//27773535
chr2:170668340-170668341(+) m6A 3'UTR       27773535
chr2:170668534-170668535(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EBER1
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
SSB
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: EBER1
Interactor2: SSB

Evidence Support:


Strong-Evidence IP
Support Database ViRBase

References:


[1]PMID 6262773 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line B95-8 cells//BJAB cells//BJAB-B1 cells//Cory cells//HR1K cells//MCUV cells//Raji cells Interactor2 expression None
Description Hybridization analyses indicate that EBER l and EBER 2 are encoded by the EcoRI-J fragment ofEBV (B95-8) DNA. In vivo both RNAs are associated with protein(s), allowing their specific precipitation by the systemic lupus erythematosus-associated antibody anti-La. The La antigen in uninfected mammalian cells consists of a heterogeneous class of small ribonucleoprotein particles, some of whose RNA components exhibit sequence homology with a highly repetitive, interspersed class ofhuman DNA designated the Alu family
[2]PMID 20719877 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line B95-8 cells//BJAB cells//BJAB-B1 cells//Cory cells//HR1K cells cells//MCUV cells//Raji cells Interactor2 expression None
Description Besides PKR, several other proteins are known to interact and form RNP complexes with the EBERs. The La protein, which assists in the correct folding of RNA Pol III transcripts (Wolin and Cedervall 2002), stably binds the 3'-U tails of both EBERs (Lerner et al. 1981a).

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