Basic Information:

  VIRBase ID:  

VHID00276921

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   EIF2AK2:  NP_002750     

Interactor Information:

	Interactor1	Interactor2
Symbol	EBER1	EIF2AK2
miRBase Accession/Entrez ID	EBER1	5610
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	lncRNA	protein
Alias	-	EIF2AK1//LEUDEN//PKR//PPP1R83//PRKR

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF2AK2	chr2:37355129(-) A-I      intronic chr2:37355122(-) A-I      intronic chr2:37355109(-) A-I      intronic chr2:37355088(-) A-I      intronic chr2:37343200(-) A-I      intronic chr2:37343204(-) A-I      intronic chr2:37355079(-) A-I      intronic chr2:37355064(-) A-I      intronic chr2:37355060(-) A-I      intronic chr2:37327631(-) A-I      3'UTR chr2:37327650(-) A-I      3'UTR chr2:37327651(-) A-I      3'UTR chr2:37327653(-) A-I      3'UTR chr2:37327659(-) A-I      3'UTR chr2:37327660(-) A-I      3'UTR chr2:37327668(-) A-I      3'UTR chr2:37327675(-) A-I      3'UTR chr2:37327676(-) A-I      3'UTR chr2:37346777(-) A-I      intronic chr2:37346802(-) A-I      intronic chr2:37346803(-) A-I      intronic chr2:37327698(-) A-I      3'UTR chr2:37346948(-) A-I      intronic chr2:37327630(-) A-I      3'UTR chr2:37327624(-) A-I      3'UTR chr2:37327615(-) A-I      3'UTR chr2:37328000(-) A-I      3'UTR chr2:37328005(-) A-I      3'UTR chr2:37328058(-) A-I      3'UTR chr2:37328067(-) A-I      3'UTR chr2:37327979(-) A-I      3'UTR chr2:37328076(-) A-I      3'UTR chr2:37328081(-) A-I      3'UTR chr2:37327613(-) A-I      3'UTR chr2:37329191(-) A-I      3'UTR chr2:37332281(-) A-I      3'UTR chr2:37328140(-) A-I      3'UTR chr2:37380781(-) A-I      intronic chr2:37329253(-) A-I      3'UTR chr2:37343224(-) A-I      intronic chr2:37380807(-) A-I      intronic chr2:37329336(-) A-I      3'UTR chr2:37329345(-) A-I      3'UTR chr2:37346811(-) A-I      intronic chr2:37330630(-) A-I      3'UTR chr2:37327642(-) A-I      3'UTR chr2:37331174(-) A-I      3'UTR chr2:37331226(-) A-I      3'UTR chr2:37331460(-) A-I      3'UTR chr2:37331464(-) A-I      3'UTR chr2:37331520(-) A-I      3'UTR chr2:37331539(-) A-I      3'UTR chr2:37327635(-) A-I      3'UTR chr2:37331632(-) A-I      3'UTR chr2:37331658(-) A-I      3'UTR chr2:37343178(-) A-I      intronic chr2:37343199(-) A-I      intronic chr2:37381832(-) A-I      intronic chr2:37382940(-) A-I      intronic chr2:37382918(-) A-I      intronic chr2:37380546(-) A-I      intronic chr2:37380544(-) A-I      intronic chr2:37380517(-) A-I      intronic chr2:37379521(-) A-I      intronic chr2:37379492(-) A-I      intronic chr2:37355152(-) A-I      intronic chr2:37335959(-) A-I      intronic chr2:37335964(-) A-I      intronic chr2:37355179(-) A-I      intronic chr2:37346951(-) A-I      intronic chr2:37347008(-) A-I      intronic chr2:37350582(-) A-I      intronic chr2:37355052(-) A-I      intronic chr2:37370115(-) A-I      intronic chr2:37369471(-) A-I      intronic chr2:37365166(-) A-I      intronic chr2:37365153(-) A-I      intronic chr2:37364623(-) A-I      intronic chr2:37359570(-) A-I      intronic chr2:37359550(-) A-I      intronic chr2:37357423(-) A-I      intronic chr2:37382939(-) A-I      intronic chr2:37355112(-) A-I      intronic chr2:37355103(-) A-I      intronic chr2:37355098(-) A-I      intronic chr2:37355078(-) A-I      intronic chr2:37355073(-) A-I      intronic chr2:37354087(-) A-I      intronic chr2:37354017(-) A-I      intronic chr2:37350593(-) A-I      intronic chr2:37350591(-) A-I      intronic chr2:37350584(-) A-I      intronic chr2:37350538(-) A-I      intronic chr2:37350529(-) A-I      intronic chr2:37350228(-) A-I      intronic chr2:37350202(-) A-I      intronic chr2:37350081(-) A-I      intronic chr2:37345466(-) A-I      intronic chr2:37344666(-) A-I      intronic chr2:37344463(-) A-I      intronic chr2:37343128(-) A-I      intronic chr2:37335950(-) A-I      intronic chr2:37335851(-) A-I      intronic chr2:37335785(-) A-I      intronic chr2:37335748(-) A-I      intronic chr2:37381841(-) A-I      intronic chr2:37383021(-) A-I      intronic chr2:37381842(-) A-I      intronic chr2:37335284(-) A-I      intronic chr2:37381815(-) A-I      intronic chr2:37381405(-) A-I      intronic chr2:37379548(-) A-I      intronic chr2:37379536(-) A-I      intronic chr2:37379501(-) A-I      intronic chr2:37379460(-) A-I      intronic chr2:37381868(-) A-I      intronic chr2:37373169(-) A-I      intronic chr2:37373060(-) A-I      intronic chr2:37373033(-) A-I      intronic chr2:37373028(-) A-I      intronic chr2:37371943(-) A-I      intronic chr2:37371898(-) A-I      intronic chr2:37371757(-) A-I      intronic chr2:37370908(-) A-I      intronic chr2:37370887(-) A-I      intronic chr2:37370810(-) A-I      intronic chr2:37370792(-) A-I      intronic chr2:37382921(-) A-I      intronic chr2:37381908(-) A-I      intronic chr2:37382927(-) A-I      intronic chr2:37370782(-) A-I      intronic chr2:37370754(-) A-I      intronic chr2:37335213(-) A-I      intronic chr2:37335206(-) A-I      intronic chr2:37370255(-) A-I      intronic chr2:37370224(-) A-I      intronic chr2:37370146(-) A-I      intronic chr2:37370127(-) A-I      intronic chr2:37382944(-) A-I      intronic chr2:37331635(-) A-I      3'UTR chr2:37331638(-) A-I      3'UTR chr2:37331667(-) A-I      3'UTR chr2:37331028(-) A-I      3'UTR chr2:37331679(-) A-I      3'UTR chr2:37331114(-) A-I      3'UTR chr2:37331712(-) A-I      3'UTR chr2:37331731(-) A-I      3'UTR chr2:37331164(-) A-I      3'UTR chr2:37331196(-) A-I      3'UTR chr2:37331245(-) A-I      3'UTR chr2:37331257(-) A-I      3'UTR chr2:37331279(-) A-I      3'UTR chr2:37331528(-) A-I      3'UTR chr2:37331552(-) A-I      3'UTR chr2:37331619(-) A-I      3'UTR chr2:37331630(-) A-I      3'UTR chr2:37331631(-) A-I      3'UTR chr2:37329357(-) A-I      3'UTR chr2:37329163(-) A-I      3'UTR chr2:37329226(-) A-I      3'UTR chr2:37329239(-) A-I      3'UTR chr2:37329333(-) A-I      3'UTR chr2:37330415(-) A-I      3'UTR chr2:37329381(-) A-I      3'UTR chr2:37329383(-) A-I      3'UTR chr2:37330342(-) A-I      3'UTR chr2:37330367(-) A-I      3'UTR chr2:37330411(-) A-I      3'UTR chr2:37330447(-) A-I      3'UTR chr2:37330460(-) A-I      3'UTR chr2:37330527(-) A-I      3'UTR chr2:37330532(-) A-I      3'UTR chr2:37330533(-) A-I      3'UTR chr2:37330571(-) A-I      3'UTR chr2:37383001(-) A-I      intronic chr2:37335944(-) A-I      intronic chr2:37373007(-) A-I      intronic chr2:37381385(-) A-I      intronic chr2:37382976(-) A-I      intronic chr2:37359726(-) A-I      intronic chr2:37350264(-) A-I      intronic chr2:37335837(-) A-I      intronic chr2:37383069(-) A-I      intronic chr2:37379602(-) A-I      intronic chr2:37350607(-) A-I      intronic chr2:37344558(-) A-I      intronic chr2:37381898(-) A-I      intronic chr2:37351420(-) A-I      intronic chr2:37362999(-) A-I      intronic chr2:37371848(-) A-I      intronic chr2:37354991(-) A-I      intronic chr2:37353895(-) A-I      intronic chr2:37364725(-) A-I      intronic chr2:37365981(-) A-I      intronic chr2:37365071(-) A-I      intronic chr2:37371840(-) A-I      intronic chr2:37335126(-) A-I      intronic chr2:37346745(-) A-I      intronic chr2:37351239(-) A-I      intronic chr2:37366060(-) A-I      intronic chr2:37338746(-) A-I      intronic chr2:37335067(-) A-I      intronic chr2:37380567(-) A-I      intronic chr2:37383077(-) A-I      intronic chr2:37364651(-) A-I      intronic chr2:37353943(-) A-I      intronic chr2:37379531(-) A-I      intronic chr2:37359490(-) A-I      intronic chr2:37355049(-) A-I      intronic chr2:37370204(-) A-I      intronic chr2:37331171(-) A-I      3'UTR chr2:37331107(-) A-I      3'UTR chr2:37330476(-) A-I      3'UTR chr2:37330373(-) A-I      3'UTR chr2:37331565(-) A-I      3'UTR chr2:37331531(-) A-I      3'UTR chr2:37331037(-) A-I      3'UTR chr2:37330534(-) A-I      3'UTR chr2:37334102(-) A-I      3'UTR chr2:37331662(-) A-I      3'UTR chr2:37329320(-) A-I      3'UTR chr2:37331510(-) A-I      3'UTR chr2:37331135(-) A-I      3'UTR chr2:37331236(-) A-I      3'UTR chr2:37329180(-) A-I      3'UTR chr2:37329228(-) A-I      3'UTR chr2:37330620(-) A-I      3'UTR chr2:37331641(-) A-I      3'UTR chr2:37329314(-) A-I      3'UTR chr2:37331515(-) A-I      3'UTR chr2:37330606(-) A-I      3'UTR chr2:37331019(-) A-I      3'UTR chr2:37330404(-) A-I      3'UTR chr2:37331220(-) A-I      3'UTR chr2:37329377(-) A-I      3'UTR chr2:37331207(-) A-I      3'UTR chr2:37331038(-) A-I      3'UTR chr2:37331595(-) A-I      3'UTR chr2:37331711(-) A-I      3'UTR chr2:37331642(-) A-I      3'UTR chr2:37331269(-) A-I      3'UTR chr2:37329248(-) A-I      3'UTR chr2:37330514(-) A-I      3'UTR chr2:37331102(-) A-I      3'UTR chr2:37329350(-) A-I      3'UTR chr2:37330540(-) A-I      3'UTR chr2:37331560(-) A-I      3'UTR chr2:37331145(-) A-I      3'UTR chr2:37329307(-) A-I      3'UTR chr2:37331627(-) A-I      3'UTR chr2:37329213(-) A-I      3'UTR chr2:37334181(-) A-I      3'UTR chr2:37330406(-) A-I      3'UTR chr2:37331277(-) A-I      3'UTR chr2:37330467(-) A-I      3'UTR chr2:37331089(-) A-I      3'UTR chr2:37330516(-) A-I      3'UTR chr2:37331525(-) A-I      3'UTR chr2:37330518(-) A-I      3'UTR chr2:37331119(-) A-I      3'UTR chr2:37330366(-) A-I      3'UTR chr2:37330611(-) A-I      3'UTR chr2:37331221(-) A-I      3'UTR chr2:37334020(-) A-I      3'UTR chr2:37329300(-) A-I      3'UTR chr2:37329243(-) A-I      3'UTR chr2:37330507(-) A-I      3'UTR chr2:37329296(-) A-I      3'UTR chr2:37334139(-) A-I      3'UTR chr2:37331239(-) A-I      3'UTR chr2:37329261(-) A-I      3'UTR chr2:37331681(-) A-I      3'UTR chr2:37331023(-) A-I      3'UTR chr2:37329211(-) A-I      3'UTR chr2:37330506(-) A-I      3'UTR chr2:37331614(-) A-I      3'UTR chr2:37329214(-) A-I      3'UTR chr2:37331281(-) A-I      3'UTR chr2:37331159(-) A-I      3'UTR chr2:37329273(-) A-I      3'UTR chr2:37330566(-) A-I      3'UTR chr2:37330587(-) A-I      3'UTR chr2:37329283(-) A-I      3'UTR chr2:37331568(-) A-I      3'UTR chr2:37331666(-) A-I      3'UTR chr2:37329179(-) A-I      3'UTR chr2:37330344(-) A-I      3'UTR chr2:37330450(-) A-I      3'UTR chr2:37329331(-) A-I      3'UTR chr2:37330576(-) A-I      3'UTR chr2:37330614(-) A-I      3'UTR chr2:37331093(-) A-I      3'UTR chr2:37330517(-) A-I      3'UTR chr2:37331640(-) A-I      3'UTR chr2:37331535(-) A-I      3'UTR chr2:37331025(-) A-I      3'UTR chr2:37330368(-) A-I      3'UTR chr2:37330371(-) A-I      3'UTR chr2:37330445(-) A-I      3'UTR chr2:37330391(-) A-I      3'UTR chr2:37329313(-) A-I      3'UTR chr2:37331030(-) A-I      3'UTR chr2:37330521(-) A-I      3'UTR chr2:37330503(-) A-I      3'UTR chr2:37331250(-) A-I      3'UTR chr2:37331639(-) A-I      3'UTR chr2:37331728(-) A-I      3'UTR chr2:37329347(-) A-I      3'UTR chr2:37331651(-) A-I      3'UTR chr2:37330345(-) A-I      3'UTR chr2:37330435(-) A-I      3'UTR chr2:37331745(-) A-I      3'UTR chr2:37330386(-) A-I      3'UTR chr2:37330612(-) A-I      3'UTR chr2:37331746(-) A-I      3'UTR chr2:37331643(-) A-I      3'UTR chr2:37331065(-) A-I      3'UTR chr2:37329235(-) A-I      3'UTR chr2:37329227(-) A-I      3'UTR chr2:37334058(-) A-I      3'UTR chr2:37329234(-) A-I      3'UTR chr2:37334146(-) A-I      3'UTR chr2:37331016(-) A-I      3'UTR chr2:37330515(-) A-I      3'UTR chr2:37379606(-) A-I      intronic chr2:37371002(-) A-I      intronic chr2:37345374(-) A-I      intronic chr2:37371888(-) A-I      intronic chr2:37380557(-) A-I      intronic chr2:37370806(-) A-I      intronic chr2:37380556(-) A-I      intronic chr2:37335877(-) A-I      intronic chr2:37383002(-) A-I      intronic chr2:37335984(-) A-I      intronic chr2:37379208(-) A-I      intronic chr2:37355014(-) A-I      intronic chr2:37372340(-) A-I      intronic chr2:37350675(-) A-I      intronic chr2:37369508(-) A-I      intronic chr2:37370927(-) A-I      intronic chr2:37372450(-) A-I      intronic chr2:37335141(-) A-I      intronic chr2:37378979(-) A-I      intronic chr2:37383079(-) A-I      intronic chr2:37371862(-) A-I      intronic chr2:37379487(-) A-I      intronic chr2:37338610(-) A-I      intronic chr2:37357427(-) A-I      intronic chr2:37366375(-) A-I      intronic chr2:37350066(-) A-I      intronic chr2:37370919(-) A-I      intronic chr2:37345269(-) A-I      intronic chr2:37381789(-) A-I      intronic chr2:37370951(-) A-I      intronic chr2:37366077(-) A-I      intronic chr2:37381801(-) A-I      intronic chr2:37371962(-) A-I      intronic chr2:37352021(-) A-I      intronic chr2:37346981(-) A-I      intronic chr2:37344541(-) A-I      intronic chr2:37370809(-) A-I      intronic chr2:37350129(-) A-I      intronic chr2:37362973(-) A-I      intronic chr2:37381819(-) A-I      intronic chr2:37371971(-) A-I      intronic chr2:37370805(-) A-I      intronic chr2:37382962(-) A-I      intronic chr2:37343484(-) A-I      intronic chr2:37380643(-) A-I      intronic chr2:37371014(-) A-I      intronic chr2:37343177(-) A-I      intronic chr2:37369381(-) A-I      intronic chr2:37364660(-) A-I      intronic chr2:37355024(-) A-I      intronic chr2:37364741(-) A-I      intronic chr2:37370289(-) A-I      intronic chr2:37369370(-) A-I      intronic chr2:37365131(-) A-I      intronic chr2:37344673(-) A-I      intronic chr2:37382912(-) A-I      intronic chr2:37359500(-) A-I      intronic chr2:37369449(-) A-I      intronic chr2:37359478(-) A-I      intronic chr2:37345280(-) A-I      intronic chr2:37381368(-) A-I      intronic chr2:37371827(-) A-I      intronic chr2:37380623(-) A-I      intronic chr2:37379603(-) A-I      intronic chr2:37371818(-) A-I      intronic chr2:37372532(-) A-I      intronic chr2:37344234(-) A-I      intronic chr2:37335916(-) A-I      intronic chr2:37381800(-) A-I      intronic chr2:37346952(-) A-I      intronic chr2:37370835(-) A-I      intronic chr2:37379597(-) A-I      intronic chr2:37350478(-) A-I      intronic chr2:37372558(-) A-I      intronic chr2:37371933(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF2AK2	chr2:37339925(-) A-I intron -    15545495 chr2:37339926(-) A-I intron -    15545495 chr2:37339928(-) A-I intron -    15545495 chr2:37339934(-) A-I intron -    15545495 chr2:37339937(-) A-I intron -    15545495   //21960545 chr2:37339938(-) A-I intron -    15545495   //21960545 chr2:37339968(-) A-I intron -    15545495   //21960545 chr2:37339977(-) A-I intron -    15545495   //21960545 chr2:37339995(-) A-I intron -    15545495   //21960545   //22327324 chr2:37339999(-) A-I intron -    15545495 chr2:37340003(-) A-I intron -    15545495 chr2:37340011(-) A-I intron -    15545495 chr2:37340013(-) A-I intron -    15545495 chr2:37340036(-) A-I intron -    15545495   //22327324 chr2:37335877(-) A-I intron -    22327324 chr2:37340034(-) A-I intron -    22327324 chr2:37380812(-) A-I intron -    22327324 chr2:37380852(-) A-I intron -    21960545   //22327324 chr2:37338311(-) A-I intron -    21960545 chr2:37338460(-) A-I intron -    21960545 chr2:37339918(-) A-I intron -    21960545 chr2:37339919(-) A-I intron -    21960545 chr2:37339935(-) A-I intron -    21960545 chr2:37339960(-) A-I intron -    21960545 chr2:37380708(-) A-I intron -    21960545 chr2:37380756(-) A-I intron -    21960545 chr2:37338311(-) A-G intron -    22484847 chr2:37338326(-) A-G intron -    22484847 chr2:37338420(-) A-G intron -    22484847 chr2:37338460(-) A-G intron -    22484847 chr2:37339977(-) A-G intron -    22484847 chr2:37339995(-) A-G intron -    22484847 chr2:37340011(-) A-G intron -    22484847 chr2:37340034(-) A-G intron -    22484847 chr2:37340036(-) A-G intron -    22484847 chr2:37380812(-) A-G intron -    22484847 chr2:37380813(-) A-G intron -    22484847 chr2:37380852(-) A-G intron -    22484847 chr2:37333961(-) A-C exon 3'UTR    22484847 chr2:37334181(-) A-G exon 3'UTR    22484847 chr2:37334182(-) G-A exon 3'UTR    22484847 chr2:37334185(-) A-T exon 3'UTR    22484847 chr2:37335067(-) A-G intron -    22484847 chr2:37335177(-) A-G intron -    22484847 chr2:37335837(-) A-G intron -    22484847 chr2:37335841(-) A-G intron -    22484847 chr2:37335850(-) A-G intron -    22484847 chr2:37335877(-) A-G intron -    22484847 chr2:37335916(-) A-G intron -    22484847 chr2:37335944(-) A-G intron -    22484847 chr2:37338639(-) A-G intron -    22484847 chr2:37344486(-) T-C intron -    22484847 chr2:37345269(-) A-G intron -    22484847 chr2:37345272(-) A-G intron -    22484847 chr2:37345397(-) A-G intron -    22484847 chr2:37345465(-) T-A intron -    22484847 chr2:37345466(-) A-T intron -    22484847 chr2:37346873(-) A-G intron -    22484847 chr2:37346952(-) A-G intron -    22484847 chr2:37346981(-) A-G intron -    22484847 chr2:37347001(-) A-G intron -    22484847 chr2:37347010(-) A-G intron -    22484847 chr2:37350066(-) A-G intron -    22484847 chr2:37350129(-) A-G intron -    22484847 chr2:37350203(-) A-G intron -    22484847 chr2:37350264(-) A-G intron -    22484847 chr2:37350477(-) A-G intron -    22484847 chr2:37350478(-) A-G intron -    22484847 chr2:37350534(-) A-G intron -    22484847 chr2:37350657(-) A-G intron -    22484847 chr2:37350675(-) A-G intron -    22484847 chr2:37353928(-) G-A intron -    22484847 chr2:37353943(-) A-G intron -    22484847 chr2:37365981(-) A-G intron -    22484847 chr2:37369381(-) A-G intron -    22484847 chr2:37370250(-) A-G intron -    22484847 chr2:37370288(-) A-G intron -    22484847 chr2:37370289(-) A-G intron -    22484847 chr2:37370776(-) A-G intron -    22484847 chr2:37370806(-) A-G intron -    22484847 chr2:37370835(-) A-G intron -    22484847 chr2:37371840(-) A-G intron -    22484847 chr2:37371862(-) A-G intron -    22484847 chr2:37371933(-) A-G intron -    22484847 chr2:37371971(-) A-G intron -    22484847 chr2:37373007(-) A-G intron -    22484847 chr2:37378959(-) A-G intron -    22484847 chr2:37379487(-) A-G intron -    22484847 chr2:37379510(-) A-G intron -    22484847 chr2:37379531(-) A-G intron -    22484847 chr2:37379597(-) A-G intron -    22484847 chr2:37379601(-) A-G intron -    22484847 chr2:37379602(-) A-G intron -    22484847 chr2:37379603(-) A-G intron -    22484847 chr2:37380557(-) A-G intron -    22484847 chr2:37381368(-) A-G intron -    22484847 chr2:37381465(-) A-G intron -    22484847 chr2:37381800(-) A-G intron -    22484847 chr2:37381819(-) A-G intron -    22484847 chr2:37381898(-) A-G intron -    22484847 chr2:37381899(-) A-G intron -    22484847 chr2:37382912(-) A-G intron -    22484847 chr2:37382936(-) A-G intron -    22484847 chr2:37382962(-) A-G intron -    22484847 chr2:37382976(-) A-G intron -    22484847 chr2:37383001(-) A-G intron -    22484847 chr2:37383002(-) A-G intron -    22484847 chr2:37383008(-) A-G intron -    22484847 chr2:37383027(-) A-G intron -    22484847 chr2:37383050(-) A-G intron -    22484847 chr2:37383069(-) A-G intron -    22484847 chr2:37383077(-) A-G intron -    22484847 chr2:37383079(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF2AK2	chr2:37326356-37326357(-) m6A 3'UTR       27773535 chr2:37326480-37326481(-) m6A 3'UTR       27773535 chr2:37326721-37326722(-) m6A 3'UTR       24981863//27773535 chr2:37327157-37327158(-) m6A 3'UTR       27773535 chr2:37328215-37328216(-) m6A 3'UTR       24981863 chr2:37328220-37328221(-) m6A 3'UTR       24981863 chr2:37328231-37328232(-) m6A 3'UTR       24981863 chr2:37328246-37328247(-) m6A 3'UTR       24981863 chr2:37328275-37328276(-) m6A 3'UTR       - chr2:37328305-37328306(-) m6A 3'UTR       - chr2:37330189-37330190(-) m6A 3'UTR       27773535 chr2:37330208-37330209(-) m6A 3'UTR       27773535 chr2:37331678-37331679(-) m6A 3'UTR       27773535 chr2:37332334-37332335(-) m6A 3'UTR       27773535 chr2:37332364-37332365(-) m6A 3'UTR       27773535 chr2:37332376-37332377(-) m6A 3'UTR       27773535 chr2:37332438-37332439(-) m6A 3'UTR       27773535 chr2:37332521-37332522(-) m6A 3'UTR       - chr2:37332536-37332537(-) m6A 3'UTR       - chr2:37332938-37332939(-) m6A 3'UTR       27773535 chr2:37332956-37332957(-) m6A 3'UTR       27773535 chr2:37333072-37333073(-) m6A 3'UTR       27773535 chr2:37333219-37333220(-) m6A 3'UTR       24981863//27773535 chr2:37333308-37333309(-) m6A 3'UTR       24981863//27773535 chr2:37333327-37333328(-) m6A 3'UTR       24981863//27773535 chr2:37333349-37333350(-) m6A 3'UTR       24981863//27773535 chr2:37333416-37333417(-) m6A 3'UTR       24981863//27773535 chr2:37333432-37333433(-) m6A 3'UTR       24981863//27773535 chr2:37333484-37333485(-) m6A 3'UTR       27773535 chr2:37333981-37333982(-) m6A 3'UTR       27773535 chr2:37336406-37336407(-) m6A CDS//exon       22575960 chr2:37336424-37336425(-) m6A CDS//exon       22575960 chr2:37341876-37341877(-) m6A CDS       27773535 chr2:37341899-37341900(-) m6A CDS       27773535 chr2:37341914-37341915(-) m6A CDS       27773535 chr2:37341948-37341949(-) m6A CDS       27773535 chr2:37341955-37341956(-) m6A CDS       24981863 chr2:37341972-37341973(-) m6A CDS       24981863 chr2:37347161-37347162(-) m6A CDS       24981863//27773535 chr2:37347170-37347171(-) m6A CDS       24981863//27773535 chr2:37347189-37347190(-) m6A CDS       24981863//27773535 chr2:37347194-37347195(-) m6A CDS       24981863//27773535 chr2:37347224-37347225(-) m6A CDS       24981863//27773535 chr2:37347232-37347233(-) m6A CDS       27773535 chr2:37347274-37347275(-) m6A CDS       27773535 chr2:37349666-37349667(-) m6A CDS       27773535 chr2:37353465-37353466(-) m6A CDS//intron       27773535 chr2:37353484-37353485(-) m6A CDS//intron       27773535 chr2:37362632-37362633(-) m6A CDS       24981863//27773535 chr2:37362648-37362649(-) m6A CDS       24981863//27773535 chr2:37363930-37363931(-) m6A exon//intron       27773535 chr2:37363988-37363989(-) m6A exon//intron       27773535 chr2:37366875-37366876(-) m6A CDS//exon       27773535 chr2:37368727-37368728(-) m6A CDS//exon       27773535 chr2:37368745-37368746(-) m6A CDS//exon       27773535 chr2:37384112-37384113(-) m6A 5'UTR       24981863 chr2:37384119-37384120(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EBER1	EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043 EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
	EIF2AK2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: EBER1
Interactor2: EIF2AK2

Evidence Support:

Strong-Evidence	Filter binding assay//IP//Luciferase reporter assay
Support Database	ViRBase

References:

[1]PMID	7901835	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Rabbit reticulocytelysate	Interactor2 expression	Downregulation
Description	The interferon-inducible protein kinase PKR interacts with a number of small viral RNA species, including adenovirus VAI RNA and the Epstein-Barr virus-encoded RNA EBER-1. Using a peptide phosphorylation assay we show here that EBER-1, like VAI, directly inhibits the activation of purified PKR. A second Epstein-Barr virus RNA, EBER-2, also regulates PKR.

[2]PMID	17619024	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells	Interactor2 expression	Downregulation
Description	Both EBERI and VAI are effective inhibitors of PKR activation by preventing trans-autophosphorylation between two PKR molecules.

[3]PMID	20399962	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells	Interactor2 expression	Downregulation
Description	EBERs have been discovered to interact with cellular proteins that play a key role in antiviral innate immunity. They bind the protein kinase RNA-dependent (PKR) and inhibit its activation, leading to resistance to PKR-mediated apoptosis.

[4]PMID	20719877	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells	Interactor2 expression	Downregulation
Description	Besides PKR, several other proteins are known to interact and form RNP complexes with the EBERs. The La protein, which assists in the correct folding of RNA Pol III transcripts (Wolin and Cedervall 2002), stably binds the 3'-U tails of both EBERs (Lerner et al. 1981a).