Detail

Basic Information:

VIRBase ID:

VHID00276919

Virus:

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

Host:

Homo sapiens

Confidence Score:

0.9820

Interaction Type:

Virus-Host interaction

Interactor Information:

	Interactor1	Interactor2
Symbol	EBER1	IL10
miRBase Accession/Entrez ID	EBER1	3586
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	lncRNA	mRNA
Alias	-	CSIF//GVHDS//IL-10//IL10A//TGIF

RNA Editing:

Resource

Symbol

Editing Position

Change

Genetic Region

RADAR

IL10

chr1:206941331(-)

A-I

3'UTR

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

EBER1

EBV-postitive Burkitt lymphoma-derived cell line (Raji)	Cytoplasm	1332043
EBV-postitive Burkitt lymphoma-derived cell line (Raji)	Nucleus	1332043

IL10

Exosome

Blood

-

Interaction Network (The top 100 interactions):

Interactor1: EBER1

Interactor2: IL10

Evidence Support:

Strong-Evidence	ELISA//Luciferase reporter assay//RT-PCR//Western blot
Support Database	ViRBase

References:

[1]PMID	11118209	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Akata cells//BL30 cells//BL41 cells//Louckes cells//Ramos cells	Interactor2 expression	Downregulation
Description	Real-time quantitative RT-PCR analysis indicated that EBER-knockout EBV-infected Akata cells were negative for IL-10 expression (Figure 6C). These results clearly demonstrated that the EBERs were responsible for IL-10 induction.

[2]PMID	18362887	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Akata cells//BL cells//Mutu cells	Interactor2 expression	Downregulation
Description	Furthermore, it was demonstrated that only EBER1 as well as only EBER2 could induce IL-10 in RIG-I expressing cell clones (Figure 2f).

[3]PMID	20399962	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Akata cells//BL cells//Mutu cells	Interactor2 expression	Downregulation
Description	Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2.