Basic Information:

  VIRBase ID:  

VHID00263837

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US22-3p:  MIMAT0028166          EIF3B:  NM_001362791     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US22-3p	EIF3B
miRBase Accession/Entrez ID	MIMAT0028166	8662
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	EIF3-ETA//EIF3-P110//EIF3-P116//EIF3S9//PRT1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF3B	chr7:2396350(+) A-I      intronic chr7:2398403(+) A-I      intronic chr7:2398435(+) A-I      intronic chr7:2409486(+) A-I      intronic chr7:2409900(+) A-I      intronic chr7:2409961(+) A-I      intronic chr7:2410044(+) A-I      intronic chr7:2410081(+) A-I      intronic chr7:2396251(+) A-I      intronic chr7:2409686(+) A-I      intronic chr7:2409901(+) A-I      intronic chr7:2409601(+) A-I      intronic chr7:2409856(+) A-I      intronic chr7:2409537(+) A-I      intronic chr7:2409674(+) A-I      intronic chr7:2409595(+) A-I      intronic chr7:2403907(+) A-I      intronic chr7:2409965(+) A-I      intronic chr7:2405372(+) A-I      intronic chr7:2410024(+) A-I      intronic chr7:2409962(+) A-I      intronic chr7:2407132(+) A-I      intronic chr7:2409953(+) A-I      intronic chr7:2409511(+) A-I      intronic chr7:2409997(+) A-I      intronic chr7:2409857(+) A-I      intronic chr7:2409952(+) A-I      intronic chr7:2409950(+) A-I      intronic chr7:2409567(+) A-I      intronic chr7:2410551(+) A-I      intronic chr7:2400880(+) A-I      intronic chr7:2404821(+) A-I      intronic chr7:2409538(+) A-I      intronic chr7:2409513(+) A-I      intronic chr7:2409951(+) A-I      intronic chr7:2401675(+) A-I      intronic chr7:2409688(+) A-I      intronic chr7:2409541(+) A-I      intronic chr7:2400812(+) A-I      intronic chr7:2409578(+) A-I      intronic chr7:2409941(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF3B	chr7:2409452(+) A-G intron -    22484847 chr7:2409541(+) A-G intron -    22484847 chr7:2409595(+) A-G intron -    22484847 chr7:2409941(+) A-G intron -    22484847 chr7:2409950(+) A-G intron -    22484847 chr7:2409952(+) A-G intron -    22484847 chr7:2409953(+) A-G intron -    22484847 chr7:2409962(+) A-G intron -    22484847 chr7:2409997(+) A-G intron -    22484847 chr7:2410001(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF3B	chr7:2393763-2393764(+) m6A 5'UTR       24981863 chr7:2393768-2393769(+) m6A 5'UTR       24981863 chr7:2393796-2393797(+) m6A 5'UTR       24981863 chr7:2393823-2393824(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960 chr7:2394697-2394698(+) m6A CDS//intron       24284625//24209618//25456834//27371828//27773536//22575960 chr7:2394757-2394758(+) m6A CDS//intron       24284625//24209618//25456834//27371828//27773536//22575960 chr7:2394972-2394973(+) m6A 5'UTR//CDS       24284625//24209618//27371828//27773536//22575960 chr7:2395028-2395029(+) m6A 5'UTR//CDS       24284625//24209618//26404942//27371828//27773536//22575960 chr7:2400365-2400366(+) Am 5'UTR//CDS       - chr7:2400413-2400414(+) m6A 5'UTR//CDS       24284625//24209618//26404942 chr7:2400432-2400433(+) m6A 5'UTR//CDS       26404942 chr7:2400450-2400451(+) m6A 5'UTR//CDS       26404942 chr7:2400529-2400530(+) m6A 5'UTR//CDS       22575960 chr7:2402743-2402744(+) m6A CDS//exon       26404942//22575960 chr7:2402757-2402758(+) m6A CDS//exon       26404942 chr7:2403270-2403271(+) m6A CDS//exon       26404942 chr7:2403336-2403337(+) m6A CDS//exon       26404942//22575960 chr7:2403369-2403370(+) m6A CDS//exon       26404942//22575960 chr7:2404012-2404013(+) m6A CDS//exon       26404942 chr7:2405980-2405981(+) m6A CDS//exon       26404942 chr7:2409130-2409131(+) Y CDS//exon       26075521 chr7:2409159-2409160(+) m6A CDS//exon       22575960 chr7:2409225-2409226(+) m6A CDS//exon       22575960 chr7:2409243-2409244(+) m6A CDS//exon       22575960 chr7:2409263-2409264(+) Am CDS//exon       - chr7:2409273-2409274(+) m6A CDS//exon       27773535//22575960 chr7:2409299-2409300(+) m6A CDS//exon       27773535//22575960 chr7:2411452-2411453(+) m6A CDS//exon       27773535//22575960 chr7:2411786-2411787(+) m6A exon//intron       - chr7:2412309-2412310(+) m6A CDS       24284625 chr7:2412332-2412333(+) m6A CDS       24284625//22575960 chr7:2412406-2412407(+) m6A CDS       24284625//22575960 chr7:2412422-2412423(+) m6A CDS       24284625//22575960 chr7:2412754-2412755(+) m6A exon//intron       24284625//22575960 chr7:2414186-2414187(+) m6A CDS//exon       25456834//24981863//22575960 chr7:2414211-2414212(+) m6A CDS//exon       25456834//24981863//22575960 chr7:2415049-2415050(+) m6A CDS//exon       24284625//22575960 chr7:2415058-2415059(+) m6A CDS//exon       24284625//22575960 chr7:2415072-2415073(+) Am CDS//exon       - chr7:2415073-2415074(+) m6A CDS//exon       24284625//22575960 chr7:2415630-2415631(+) m6A exon//intron       24284625//22575960 chr7:2415658-2415659(+) m6A exon//intron       24284625//22575960 chr7:2416588-2416589(+) m6A CDS//exon       22575960 chr7:2416608-2416609(+) m6A CDS//exon       22575960 chr7:2416701-2416702(+) Cm CDS//exon       - chr7:2418364-2418365(+) m6A CDS//exon       24981863//27773535 chr7:2418511-2418512(+) m6A exon//intron       24981863//27773535 chr7:2419034-2419035(+) m6A CDS//exon       24284625//24981863//26404942//22575960 chr7:2419049-2419050(+) m6A CDS//exon       24284625//24981863//26404942//22575960 chr7:2419078-2419079(+) m6A CDS//exon       24284625//24981863//26404942//22575960 chr7:2419845-2419846(+) m6A 3'UTR//exon//intron       24284625//24981863//22575960 chr7:2419878-2419879(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr7:2419997-2419998(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr7:2420121-2420122(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr7:2420143-2420144(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr7:2420233-2420234(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr7:2420275-2420276(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr7:2420348-2420349(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr7:2420366-2420367(+) m6A 3'UTR//exon       24284625//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EIF3B	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US22-3p
Interactor2: EIF3B

Evidence Support:

Prediction-Evidence	miRanda//PITA//RNAHybrid//Targetscan
Support Database	VmiReg