Basic Information:

  VIRBase ID:  

VHID00259544

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US4-3p:  MIMAT0026628          FBXO45:  NM_001105573     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US4-3p	FBXO45
miRBase Accession/Entrez ID	MIMAT0026628	200933
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Fbx45

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FBXO45	chr3:196310779(+) A-I      intronic chr3:196303282(+) A-I      intronic chr3:196307146(+) A-I      intronic chr3:196302249(+) A-I      intronic chr3:196310701(+) A-I      intronic chr3:196315112(+) A-I      3'UTR chr3:196302763(+) A-I      intronic chr3:196303384(+) A-I      intronic chr3:196310688(+) A-I      intronic chr3:196310789(+) A-I      intronic chr3:196302250(+) A-I      intronic chr3:196297855(+) A-I      intronic chr3:196310727(+) A-I      intronic chr3:196297370(+) A-I      intronic chr3:196303315(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FBXO45	chr3:196314984(+) A-G intron -    21725310 chr3:196310688(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FBXO45	chr3:196296078-196296079(+) m6A CDS//intron       24209618 chr3:196296138-196296139(+) m6A CDS//intron       24209618 chr3:196304408-196304409(+) m6A 5'UTR//CDS       24981863//22608085 chr3:196304440-196304441(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr3:196304609-196304610(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:196311031-196311032(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:196311045-196311046(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:196311095-196311096(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311173-196311174(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311212-196311213(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311248-196311249(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311284-196311285(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311295-196311296(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311311-196311312(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:196311542-196311543(+) m6A 3'UTR       24981863 chr3:196313011-196313012(+) m6A 3'UTR       27773535 chr3:196313046-196313047(+) m6A 3'UTR       27773535 chr3:196313075-196313076(+) m6A 3'UTR       27773535 chr3:196313193-196313194(+) m6A 3'UTR       27773535 chr3:196313232-196313233(+) m6A 3'UTR       27773535 chr3:196313238-196313239(+) m6A 3'UTR       27773535 chr3:196313260-196313261(+) m6A 3'UTR       27773535 chr3:196313726-196313727(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hcmv-miR-US4-3p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
	FBXO45	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US4-3p
Interactor2: FBXO45

Evidence Support:

Prediction-Evidence	miRanda//PITA//Targetscan
Support Database	VmiReg