Basic Information:

  VIRBase ID:  

VHID00259386

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US4-3p:  MIMAT0026628          KLHDC3:  NM_057161     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US4-3p	KLHDC3
miRBase Accession/Entrez ID	MIMAT0026628	116138
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ20C7.3//PEAS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHDC3	chr6:42983441(+) A-I      intronic chr6:42983774(+) A-I      intronic chr6:42983406(+) A-I      intronic chr6:42983931(+) A-I      intronic chr6:42983428(+) A-I      intronic chr6:42983468(+) A-I      intronic chr6:42983423(+) A-I      intronic chr6:42983839(+) A-I      intronic chr6:42983729(+) A-I      intronic chr6:42983410(+) A-I      intronic chr6:42983945(+) A-I      intronic chr6:42983332(+) A-I      intronic chr6:42983778(+) A-I      intronic chr6:42983840(+) A-I      intronic chr6:42983524(+) A-I      intronic chr6:42983427(+) A-I      intronic chr6:42983813(+) A-I      intronic chr6:42983333(+) A-I      intronic chr6:42983791(+) A-I      intronic chr6:42983873(+) A-I      intronic chr6:42983857(+) A-I      intronic chr6:42983378(+) A-I      intronic chr6:42983815(+) A-I      intronic chr6:42983429(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KLHDC3	chr6:42983406(+) A-G intron -    22484847 chr6:42983423(+) A-G intron -    22484847 chr6:42983854(+) A-G intron -    22484847 chr6:42983857(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHDC3	chr6:42981971-42981972(+) m6A 5'UTR       24981863 chr6:42982002-42982003(+) m6A 5'UTR       24284625//24981863 chr6:42982054-42982055(+) m6A 5'UTR       24284625//24981863 chr6:42984734-42984735(+) m6A intron       24284625//24981863 chr6:42984942-42984943(+) m6A 5'UTR//CDS       - chr6:42985625-42985626(+) m6A CDS//intron       22575960 chr6:42985648-42985649(+) m6A CDS//intron       22575960 chr6:42985886-42985887(+) m6A CDS       22575960 chr6:42988561-42988562(+) m6A 3'UTR//intron       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hcmv-miR-US4-3p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
	KLHDC3	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US4-3p
Interactor2: KLHDC3

Evidence Support:

Prediction-Evidence	PITA//RNAHybrid//Targetscan
Support Database	VmiReg