Basic Information:

  VIRBase ID:  

VHID00258058

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US4-3p:  MIMAT0026628          NPM1:  NR_149149     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US4-3p	NPM1
miRBase Accession/Entrez ID	MIMAT0026628	4869
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	B23//NPM

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NPM1	chr5:170828282(+) A-I      intronic chr5:170828210(+) A-I      intronic chr5:170828161(+) A-I      intronic chr5:170827661(+) A-I      intronic chr5:170827635(+) A-I      intronic chr5:170827626(+) A-I      intronic chr5:170827622(+) A-I      intronic chr5:170825708(+) A-I      intronic chr5:170827618(+) A-I      intronic chr5:170827602(+) A-I      intronic chr5:170827600(+) A-I      intronic chr5:170827590(+) A-I      intronic chr5:170827587(+) A-I      intronic chr5:170821358(+) A-I      intronic chr5:170821361(+) A-I      intronic chr5:170821392(+) A-I      intronic chr5:170821406(+) A-I      intronic chr5:170821973(+) A-I      intronic chr5:170821987(+) A-I      intronic chr5:170822021(+) A-I      intronic chr5:170822030(+) A-I      intronic chr5:170822090(+) A-I      intronic chr5:170822433(+) A-I      intronic chr5:170822470(+) A-I      intronic chr5:170823735(+) A-I      intronic chr5:170823789(+) A-I      intronic chr5:170823862(+) A-I      intronic chr5:170823883(+) A-I      intronic chr5:170823897(+) A-I      intronic chr5:170823898(+) A-I      intronic chr5:170823927(+) A-I      intronic chr5:170823960(+) A-I      intronic chr5:170825617(+) A-I      intronic chr5:170825733(+) A-I      intronic chr5:170825621(+) A-I      intronic chr5:170823199(+) A-I      intronic chr5:170827597(+) A-I      intronic chr5:170825660(+) A-I      intronic chr5:170837083(+) A-I      intronic chr5:170837076(+) A-I      intronic chr5:170836449(+) A-I      intronic chr5:170836405(+) A-I      intronic chr5:170836372(+) A-I      intronic chr5:170832009(+) A-I      intronic chr5:170828680(+) A-I      intronic chr5:170828540(+) A-I      intronic chr5:170828273(+) A-I      intronic chr5:170828271(+) A-I      intronic chr5:170828268(+) A-I      intronic chr5:170828204(+) A-I      intronic chr5:170828155(+) A-I      intronic chr5:170828142(+) A-I      intronic chr5:170826503(+) A-I      intronic chr5:170826405(+) A-I      intronic chr5:170826035(+) A-I      intronic chr5:170826029(+) A-I      intronic chr5:170826007(+) A-I      intronic chr5:170825897(+) A-I      intronic chr5:170825636(+) A-I      intronic chr5:170836404(+) A-I      intronic chr5:170828283(+) A-I      intronic chr5:170823786(+) A-I      intronic chr5:170828668(+) A-I      intronic chr5:170822007(+) A-I      intronic chr5:170822024(+) A-I      intronic chr5:170828185(+) A-I      intronic chr5:170822443(+) A-I      intronic chr5:170825619(+) A-I      intronic chr5:170828567(+) A-I      intronic chr5:170820936(+) A-I      intronic chr5:170822397(+) A-I      intronic chr5:170825994(+) A-I      intronic chr5:170825524(+) A-I      intronic chr5:170822104(+) A-I      intronic chr5:170825996(+) A-I      intronic chr5:170826038(+) A-I      intronic chr5:170836785(+) A-I      intronic chr5:170826502(+) A-I      intronic chr5:170828255(+) A-I      intronic chr5:170822128(+) A-I      intronic chr5:170836477(+) A-I      intronic chr5:170821933(+) A-I      intronic chr5:170821439(+) A-I      intronic chr5:170820859(+) A-I      intronic chr5:170828206(+) A-I      intronic chr5:170836395(+) A-I      intronic chr5:170826075(+) A-I      intronic chr5:170836958(+) A-I      intronic chr5:170825984(+) A-I      intronic chr5:170828625(+) A-I      intronic chr5:170822484(+) A-I      intronic chr5:170828128(+) A-I      intronic chr5:170822487(+) A-I      intronic chr5:170836409(+) A-I      intronic chr5:170826509(+) A-I      intronic chr5:170825917(+) A-I      intronic chr5:170822133(+) A-I      intronic chr5:170836928(+) A-I      intronic chr5:170822489(+) A-I      intronic chr5:170828241(+) A-I      intronic chr5:170828675(+) A-I      intronic chr5:170822077(+) A-I      intronic chr5:170825523(+) A-I      intronic chr5:170836967(+) A-I      intronic chr5:170825588(+) A-I      intronic chr5:170836394(+) A-I      intronic chr5:170822036(+) A-I      intronic chr5:170828494(+) A-I      intronic chr5:170832011(+) A-I      intronic chr5:170824933(+) A-I      intronic chr5:170832103(+) A-I      intronic chr5:170828212(+) A-I      intronic chr5:170826383(+) A-I      intronic chr5:170825736(+) A-I      intronic chr5:170821981(+) A-I      intronic chr5:170825623(+) A-I      intronic chr5:170836400(+) A-I      intronic chr5:170826055(+) A-I      intronic chr5:170826437(+) A-I      intronic chr5:170825741(+) A-I      intronic chr5:170828602(+) A-I      intronic chr5:170825599(+) A-I      intronic chr5:170828242(+) A-I      intronic chr5:170823857(+) A-I      intronic chr5:170822514(+) A-I      intronic chr5:170821231(+) A-I      intronic chr5:170836397(+) A-I      intronic chr5:170836911(+) A-I      intronic chr5:170827613(+) A-I      intronic chr5:170826493(+) A-I      intronic chr5:170825598(+) A-I      intronic chr5:170825517(+) A-I      intronic chr5:170828566(+) A-I      intronic chr5:170828667(+) A-I      intronic chr5:170825613(+) A-I      intronic chr5:170836997(+) A-I      intronic chr5:170826117(+) A-I      intronic chr5:170828274(+) A-I      intronic chr5:170825928(+) A-I      intronic chr5:170836462(+) A-I      intronic chr5:170828211(+) A-I      intronic chr5:170825668(+) A-I      intronic chr5:170832006(+) A-I      intronic chr5:170820939(+) A-I      intronic chr5:170828570(+) A-I      intronic chr5:170822027(+) A-I      intronic chr5:170825641(+) A-I      intronic chr5:170825887(+) A-I      intronic chr5:170828251(+) A-I      intronic chr5:170821233(+) A-I      intronic chr5:170828152(+) A-I      intronic chr5:170831995(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NPM1	chr5:170836785(+) A-I intron -    15258596 chr5:170836911(+) A-I intron -    15258596 chr5:170836928(+) A-I intron -    15258596 chr5:170825641(+) A-I intron -    22327324 chr5:170836400(+) A-I intron -    22327324 chr5:170823856(+) A-I intron -    21960545 chr5:170828615(+) A-I intron -    21960545 chr5:170836335(+) A-I intron -    21960545 chr5:170817743(+) C-T intron -    22484847 chr5:170821138(+) T-C intron -    22484847 chr5:170821139(+) G-A intron -    22484847 chr5:170821359(+) A-G intron -    22484847 chr5:170821981(+) A-G intron -    22484847 chr5:170822007(+) A-G intron -    22484847 chr5:170822023(+) A-G intron -    22484847 chr5:170822024(+) A-G intron -    22484847 chr5:170822025(+) A-G intron -    22484847 chr5:170822378(+) G-A intron -    22484847 chr5:170822397(+) A-G intron -    22484847 chr5:170822443(+) A-G intron -    22484847 chr5:170822484(+) A-G intron -    22484847 chr5:170822487(+) A-G intron -    22484847 chr5:170822489(+) A-G intron -    22484847 chr5:170822514(+) A-G intron -    22484847 chr5:170823856(+) A-G intron -    22484847 chr5:170823857(+) A-G intron -    22484847 chr5:170823950(+) T-C intron -    22484847 chr5:170824806(+) C-T intron -    22484847 chr5:170824823(+) G-T intron -    22484847 chr5:170824892(+) T-G intron -    22484847 chr5:170824933(+) A-G intron -    22484847 chr5:170824947(+) C-A intron -    22484847 chr5:170824948(+) A-C intron -    22484847 chr5:170825504(+) T-G intron -    22484847 chr5:170825517(+) A-G intron -    22484847 chr5:170825538(+) A-G intron -    22484847 chr5:170825588(+) A-G intron -    22484847 chr5:170825628(+) A-G intron -    22484847 chr5:170825641(+) A-G intron -    22484847 chr5:170825654(+) A-G intron -    22484847 chr5:170825917(+) A-G intron -    22484847 chr5:170825994(+) A-G intron -    22484847 chr5:170826020(+) A-G intron -    22484847 chr5:170826021(+) A-G intron -    22484847 chr5:170826058(+) A-G intron -    22484847 chr5:170826383(+) A-G intron -    22484847 chr5:170826509(+) A-G intron -    22484847 chr5:170827504(+) G-A intron -    22484847 chr5:170828147(+) A-G intron -    22484847 chr5:170828152(+) A-G intron -    22484847 chr5:170828206(+) A-G intron -    22484847 chr5:170828219(+) A-G intron -    22484847 chr5:170828242(+) A-G intron -    22484847 chr5:170828255(+) A-G intron -    22484847 chr5:170828472(+) A-G intron -    22484847 chr5:170828566(+) A-G intron -    22484847 chr5:170828567(+) A-G intron -    22484847 chr5:170828570(+) A-G intron -    22484847 chr5:170828602(+) A-G intron -    22484847 chr5:170828615(+) A-G intron -    22484847 chr5:170828630(+) T-C intron -    22484847 chr5:170828667(+) A-G intron -    22484847 chr5:170831995(+) A-G intron -    22484847 chr5:170832059(+) A-G intron -    22484847 chr5:170836335(+) A-G intron -    22484847 chr5:170836396(+) A-G intron -    22484847 chr5:170836397(+) A-G intron -    22484847 chr5:170836398(+) A-G intron -    22484847 chr5:170836400(+) A-G intron -    22484847 chr5:170836450(+) A-G intron -    22484847 chr5:170836462(+) A-G intron -    22484847 chr5:170836898(+) A-G intron -    22484847 chr5:170836902(+) A-G intron -    22484847 chr5:170836911(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NPM1	chr5:170814968-170814969(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170814974-170814975(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170814998-170814999(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170817061-170817062(+) m6A CDS//exon//intron       27773535//22575960 chr5:170817142-170817143(+) m6A exon//intron       27773535 chr5:170817155-170817156(+) m6A exon//intron       27773535 chr5:170818270-170818271(+) m6A exon//intron       - chr5:170818348-170818349(+) Y 5'UTR//CDS//exon       26075521 chr5:170818789-170818790(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170819762-170819763(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170819877-170819878(+) m6A exon//intron       24981863//27773535//22575960 chr5:170819928-170819929(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170827812-170827813(+) m6A exon//intron       24981863//27773535//22575960 chr5:170827897-170827898(+) m6A CDS//exon//intron       24981863//27773535//27371828//22575960 chr5:170827904-170827905(+) m6A CDS//exon//intron       24981863//27773535//27371828//22575960 chr5:170832307-170832308(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832325-170832326(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832335-170832336(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832344-170832345(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832355-170832356(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832372-170832373(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832430-170832431(+) m6A exon//intron       24981863//27773535//22575960 chr5:170832473-170832474(+) m6A exon//intron       24981863//27773535 chr5:170832696-170832697(+) m6A exon//intron       24981863 chr5:170832733-170832734(+) m6A exon//intron       24981863 chr5:170833409-170833410(+) m6A 3'UTR//intron       24981863 chr5:170833468-170833469(+) m6A 3'UTR//intron       24981863 chr5:170833506-170833507(+) m6A 3'UTR//intron       27773535 chr5:170833574-170833575(+) m6A 3'UTR//intron       27773535 chr5:170833626-170833627(+) m6A 3'UTR//intron       27773535 chr5:170837582-170837583(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837665-170837666(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837754-170837755(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837802-170837803(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837824-170837825(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837843-170837844(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837867-170837868(+) m6A 3'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hcmv-miR-US4-3p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
	NPM1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US4-3p
Interactor2: NPM1

Evidence Support:

Prediction-Evidence	miRanda//Targetscan
Support Database	VmiReg