Basic Information:

  VIRBase ID:  

VHID00256514

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-UL112-5p:  MIMAT0026552          SNAP23:  NM_003825     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-UL112-5p	SNAP23
miRBase Accession/Entrez ID	MIMAT0026552	8773
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HsT17016//SNAP-23//SNAP23A//SNAP23B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SNAP23	chr15:42800207(+) A-I      intronic chr15:42800277(+) A-I      intronic chr15:42800332(+) A-I      intronic chr15:42815184(+) A-I      intronic chr15:42824489(+) A-I      3'UTR chr15:42824566(+) A-I      3'UTR chr15:42799277(+) A-I      intronic chr15:42824543(+) A-I      3'UTR chr15:42796397(+) A-I      intronic chr15:42800204(+) A-I      intronic chr15:42815182(+) A-I      intronic chr15:42815282(+) A-I      intronic chr15:42816181(+) A-I      intronic chr15:42816190(+) A-I      intronic chr15:42795921(+) A-I      intronic chr15:42816196(+) A-I      intronic chr15:42816253(+) A-I      intronic chr15:42817400(+) A-I      intronic chr15:42817405(+) A-I      intronic chr15:42817416(+) A-I      intronic chr15:42822702(+) A-I      intronic chr15:42817419(+) A-I      intronic chr15:42822857(+) A-I      intronic chr15:42817435(+) A-I      intronic chr15:42817445(+) A-I      intronic chr15:42801867(+) A-I      intronic chr15:42817451(+) A-I      intronic chr15:42817455(+) A-I      intronic chr15:42817516(+) A-I      intronic chr15:42819687(+) A-I      intronic chr15:42819739(+) A-I      intronic chr15:42819794(+) A-I      intronic chr15:42819845(+) A-I      intronic chr15:42820858(+) A-I      intronic chr15:42820888(+) A-I      intronic chr15:42793346(+) A-I      intronic chr15:42820913(+) A-I      intronic chr15:42822392(+) A-I      intronic chr15:42822717(+) A-I      intronic chr15:42822873(+) A-I      intronic chr15:42822889(+) A-I      intronic chr15:42822927(+) A-I      intronic chr15:42796255(+) A-I      intronic chr15:42802437(+) A-I      intronic chr15:42800364(+) A-I      intronic chr15:42815173(+) A-I      intronic chr15:42791289(+) A-I      intronic chr15:42822918(+) A-I      intronic chr15:42802473(+) A-I      intronic chr15:42815067(+) A-I      intronic chr15:42798630(+) A-I      intronic chr15:42810775(+) A-I      intronic chr15:42810042(+) A-I      intronic chr15:42801737(+) A-I      intronic chr15:42815113(+) A-I      intronic chr15:42789708(+) A-I      intronic chr15:42798704(+) A-I      intronic chr15:42800418(+) A-I      intronic chr15:42815142(+) A-I      intronic chr15:42815172(+) A-I      intronic chr15:42794645(+) A-I      intronic chr15:42791384(+) A-I      intronic chr15:42796308(+) A-I      intronic chr15:42800281(+) A-I      intronic chr15:42795599(+) A-I      intronic chr15:42789590(+) A-I      intronic chr15:42796266(+) A-I      intronic chr15:42800301(+) A-I      intronic chr15:42815307(+) A-I      intronic chr15:42793305(+) A-I      intronic chr15:42817934(+) A-I      intronic chr15:42789594(+) A-I      intronic chr15:42791433(+) A-I      intronic chr15:42791446(+) A-I      intronic chr15:42792092(+) A-I      intronic chr15:42788705(+) A-I      intronic chr15:42792132(+) A-I      intronic chr15:42793298(+) A-I      intronic chr15:42817310(+) A-I      intronic chr15:42793308(+) A-I      intronic chr15:42794355(+) A-I      intronic chr15:42795777(+) A-I      intronic chr15:42798166(+) A-I      intronic chr15:42816068(+) A-I      intronic chr15:42794429(+) A-I      intronic chr15:42788844(+) A-I      intronic chr15:42795239(+) A-I      intronic chr15:42799216(+) A-I      intronic chr15:42796403(+) A-I      intronic chr15:42802357(+) A-I      intronic chr15:42800382(+) A-I      intronic chr15:42796419(+) A-I      intronic chr15:42795207(+) A-I      intronic chr15:42796420(+) A-I      intronic chr15:42796455(+) A-I      intronic chr15:42800215(+) A-I      intronic chr15:42800264(+) A-I      intronic chr15:42800267(+) A-I      intronic chr15:42800279(+) A-I      intronic chr15:42800328(+) A-I      intronic chr15:42800395(+) A-I      intronic chr15:42817316(+) A-I      intronic chr15:42789318(+) A-I      intronic chr15:42800463(+) A-I      intronic chr15:42800464(+) A-I      intronic chr15:42822343(+) A-I      intronic chr15:42801910(+) A-I      intronic chr15:42801718(+) A-I      intronic chr15:42801790(+) A-I      intronic chr15:42801879(+) A-I      intronic chr15:42804867(+) A-I      intronic chr15:42810729(+) A-I      intronic chr15:42791475(+) A-I      intronic chr15:42824526(+) A-I      3'UTR chr15:42824454(+) A-I      3'UTR chr15:42824478(+) A-I      3'UTR chr15:42824444(+) A-I      3'UTR chr15:42824313(+) A-I      3'UTR chr15:42824463(+) A-I      3'UTR chr15:42824472(+) A-I      3'UTR chr15:42824486(+) A-I      3'UTR chr15:42824494(+) A-I      3'UTR chr15:42800185(+) A-I      intronic chr15:42789681(+) A-I      intronic chr15:42817311(+) A-I      intronic chr15:42796278(+) A-I      intronic chr15:42796250(+) A-I      intronic chr15:42788920(+) A-I      intronic chr15:42796318(+) A-I      intronic chr15:42819905(+) A-I      intronic chr15:42801738(+) A-I      intronic chr15:42802080(+) A-I      intronic chr15:42815200(+) A-I      intronic chr15:42796452(+) A-I      intronic chr15:42788875(+) A-I      intronic chr15:42822346(+) A-I      intronic chr15:42822420(+) A-I      intronic chr15:42815185(+) A-I      intronic chr15:42822882(+) A-I      intronic chr15:42822689(+) A-I      intronic chr15:42800466(+) A-I      intronic chr15:42788821(+) A-I      intronic chr15:42817819(+) A-I      intronic chr15:42819812(+) A-I      intronic chr15:42793261(+) A-I      intronic chr15:42802569(+) A-I      intronic chr15:42796346(+) A-I      intronic chr15:42816046(+) A-I      intronic chr15:42809960(+) A-I      intronic chr15:42788817(+) A-I      intronic chr15:42800325(+) A-I      intronic chr15:42817381(+) A-I      intronic chr15:42792850(+) A-I      intronic chr15:42800431(+) A-I      intronic chr15:42819923(+) A-I      intronic chr15:42817814(+) A-I      intronic chr15:42800314(+) A-I      intronic chr15:42815218(+) A-I      intronic chr15:42816216(+) A-I      intronic chr15:42801897(+) A-I      intronic chr15:42817297(+) A-I      intronic chr15:42798245(+) A-I      intronic chr15:42788795(+) A-I      intronic chr15:42822384(+) A-I      intronic chr15:42822797(+) A-I      intronic chr15:42802012(+) A-I      intronic chr15:42817511(+) A-I      intronic chr15:42795860(+) A-I      intronic chr15:42800317(+) A-I      intronic chr15:42800462(+) A-I      intronic chr15:42800342(+) A-I      intronic chr15:42792236(+) A-I      intronic chr15:42799181(+) A-I      intronic chr15:42788750(+) A-I      intronic chr15:42822825(+) A-I      intronic chr15:42815092(+) A-I      intronic chr15:42815244(+) A-I      intronic chr15:42815107(+) A-I      intronic chr15:42819906(+) A-I      intronic chr15:42795836(+) A-I      intronic chr15:42817379(+) A-I      intronic chr15:42800432(+) A-I      intronic chr15:42801848(+) A-I      intronic chr15:42815097(+) A-I      intronic chr15:42792113(+) A-I      intronic chr15:42792793(+) A-I      intronic chr15:42800199(+) A-I      intronic chr15:42801898(+) A-I      intronic chr15:42795984(+) A-I      intronic chr15:42798696(+) A-I      intronic chr15:42822419(+) A-I      intronic chr15:42800408(+) A-I      intronic chr15:42793281(+) A-I      intronic chr15:42819919(+) A-I      intronic chr15:42791522(+) A-I      intronic chr15:42817755(+) A-I      intronic chr15:42817836(+) A-I      intronic chr15:42816084(+) A-I      intronic chr15:42800450(+) A-I      intronic chr15:42809243(+) A-I      intronic chr15:42822893(+) A-I      intronic chr15:42819848(+) A-I      intronic chr15:42799290(+) A-I      intronic chr15:42795842(+) A-I      intronic chr15:42817302(+) A-I      intronic chr15:42819787(+) A-I      intronic chr15:42815136(+) A-I      intronic chr15:42788651(+) A-I      intronic chr15:42793812(+) A-I      intronic chr15:42810757(+) A-I      intronic chr15:42810038(+) A-I      intronic chr15:42802042(+) A-I      intronic chr15:42802534(+) A-I      intronic chr15:42822868(+) A-I      intronic chr15:42800396(+) A-I      intronic chr15:42801742(+) A-I      intronic chr15:42809978(+) A-I      intronic chr15:42801821(+) A-I      intronic chr15:42817884(+) A-I      intronic chr15:42819946(+) A-I      intronic chr15:42800274(+) A-I      intronic chr15:42788731(+) A-I      intronic chr15:42802192(+) A-I      intronic chr15:42802452(+) A-I      intronic chr15:42819770(+) A-I      intronic chr15:42799065(+) A-I      intronic chr15:42800336(+) A-I      intronic chr15:42789765(+) A-I      intronic chr15:42815224(+) A-I      intronic chr15:42789707(+) A-I      intronic chr15:42798283(+) A-I      intronic chr15:42822373(+) A-I      intronic chr15:42819945(+) A-I      intronic chr15:42819960(+) A-I      intronic chr15:42798224(+) A-I      intronic chr15:42798273(+) A-I      intronic chr15:42792213(+) A-I      intronic chr15:42822905(+) A-I      intronic chr15:42824495(+) A-I      3'UTR chr15:42824369(+) A-I      3'UTR chr15:42824346(+) A-I      3'UTR chr15:42824545(+) A-I      3'UTR chr15:42824370(+) A-I      3'UTR chr15:42824364(+) A-I      3'UTR chr15:42824430(+) A-I      3'UTR chr15:42824548(+) A-I      3'UTR chr15:42824394(+) A-I      3'UTR chr15:42824455(+) A-I      3'UTR chr15:42824544(+) A-I      3'UTR chr15:42824428(+) A-I      3'UTR chr15:42824557(+) A-I      3'UTR chr15:42824469(+) A-I      3'UTR chr15:42824393(+) A-I      3'UTR chr15:42824309(+) A-I      3'UTR chr15:42824348(+) A-I      3'UTR chr15:42824390(+) A-I      3'UTR chr15:42824418(+) A-I      3'UTR chr15:42823795(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SNAP23	chr15:42822882(+) A-I intron -    22327324 chr15:42824348(+) A-I intron -    22327324 chr15:42824495(+) A-I intron -    22327324 chr15:42793305(+) A-I intron -    21960545 chr15:42793308(+) A-I intron -    21960545 chr15:42819812(+) A-I intron -    21960545 chr15:42796308(+) A-G intron -    22484847 chr15:42802498(+) T-C intron -    22484847 chr15:42807028(+) G-A intron -    22484847 chr15:42815224(+) A-G intron -    22484847 chr15:42815244(+) A-G intron -    22484847 chr15:42817311(+) A-G intron -    22484847 chr15:42819168(+) T-C intron -    22484847 chr15:42822882(+) A-G intron -    22484847 chr15:42824348(+) A-G intron -    22484847 chr15:42824393(+) A-G intron -    22484847 chr15:42824418(+) A-G intron -    22484847 chr15:42824478(+) A-G intron -    22484847 chr15:42824495(+) A-G intron -    22484847 chr15:42824545(+) A-G intron -    22484847 chr15:42824548(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SNAP23	chr15:42787961-42787962(+) m6A 5'UTR//intron       - chr15:42805617-42805618(+) m6A 3'UTR//5'UTR//CDS//exon       24981863 chr15:42805637-42805638(+) m6A 3'UTR//CDS//exon       24981863 chr15:42807443-42807444(+) m6A 3'UTR//CDS//exon       24981863 chr15:42807464-42807465(+) m6A 3'UTR//CDS//exon       24981863 chr15:42807479-42807480(+) m6A 3'UTR//CDS//exon       24981863 chr15:42807490-42807491(+) m6A 3'UTR//CDS//exon       24981863 chr15:42807499-42807500(+) m6A 3'UTR//CDS//exon       24981863 chr15:42807510-42807511(+) m6A 3'UTR//CDS//exon       24981863 chr15:42821910-42821911(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr15:42821949-42821950(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr15:42821961-42821962(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr15:42822012-42822013(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr15:42824475-42824476(+) m6A 3'UTR//intron       24209618 chr15:42824506-42824507(+) m6A 3'UTR//intron       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SNAP23	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-UL112-5p
Interactor2: SNAP23

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Western blot
Weak-Evidence	RIP-Chip
Support Database	VmiReg

References:

PMID	24629342	Target region	None
Source	VmiReg	Interactor1 expression	None
Tissue or cell line	293T cells	Interactor2 expression	None
Description	We find that HCMV miRs UL112-1,US5-1, and US5-2 target multiple components of the host secretory pathway, including VAMP3, RAB5C, RAB11A, SNAP23, and CDC42.