Detail Information

Basic Information:


  VIRBase ID:  

VHID00248292

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-UL70-3p:           APPL2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-UL70-3p APPL2
miRBase
Accession/Entrez ID		 MIMAT0003343 55198
Organism Human betaherpesvirus 5 (HHV-5) Homo sapiens
Category miRNA mRNA
Alias - DIP13B

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR APPL2
chr12:105590311(-) A-I      intronic
chr12:105626426(-) A-I      intronic
chr12:105590335(-) A-I      intronic
chr12:105590491(-) A-I      intronic
chr12:105589676(-) A-I      intronic
chr12:105590338(-) A-I      intronic
chr12:105623725(-) A-I      intronic
chr12:105590360(-) A-I      intronic
chr12:105590352(-) A-I      intronic
chr12:105623721(-) A-I      intronic
chr12:105609693(-) A-I      intronic
chr12:105626351(-) A-I      intronic
chr12:105623667(-) A-I      intronic
chr12:105589615(-) A-I      intronic
chr12:105590443(-) A-I      intronic
chr12:105623549(-) A-I      intronic
chr12:105590412(-) A-I      intronic
chr12:105620759(-) A-I      intronic
chr12:105623784(-) A-I      intronic
chr12:105590465(-) A-I      intronic
chr12:105590325(-) A-I      intronic
chr12:105626536(-) A-I      intronic
chr12:105589563(-) A-I      intronic
chr12:105589814(-) A-I      intronic
chr12:105590346(-) A-I      intronic
chr12:105590394(-) A-I      intronic
chr12:105590392(-) A-I      intronic
chr12:105590389(-) A-I      intronic
chr12:105626459(-) A-I      intronic
chr12:105626430(-) A-I      intronic
chr12:105589588(-) A-I      intronic
chr12:105589717(-) A-I      intronic
chr12:105609657(-) A-I      intronic
chr12:105590281(-) A-I      intronic
chr12:105589689(-) A-I      intronic
chr12:105590416(-) A-I      intronic
chr12:105590351(-) A-I      intronic
chr12:105589827(-) A-I      intronic
chr12:105589711(-) A-I      intronic
chr12:105623555(-) A-I      intronic
chr12:105590286(-) A-I      intronic
chr12:105620988(-) A-I      intronic
chr12:105589738(-) A-I      intronic
chr12:105589587(-) A-I      intronic
chr12:105589570(-) A-I      intronic
chr12:105590240(-) A-I      intronic
chr12:105623584(-) A-I      intronic
chr12:105589667(-) A-I      intronic
chr12:105590494(-) A-I      intronic
chr12:105626420(-) A-I      intronic
chr12:105571652(-) A-I      intronic
chr12:105589616(-) A-I      intronic
chr12:105590310(-) A-I      intronic
chr12:105590510(-) A-I      intronic
chr12:105589721(-) A-I      intronic
chr12:105623583(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED APPL2
chr12:105590281(-) A-I intron -    22028664
chr12:105590310(-) A-I intron -    22028664
chr12:105590325(-) A-I intron -    22028664
chr12:105590335(-) A-I intron -    22028664
chr12:105590338(-) A-I intron -    22028664
chr12:105590346(-) A-I intron -    22028664
chr12:105590351(-) A-I intron -    22028664
chr12:105590352(-) A-I intron -    22028664
chr12:105590412(-) A-I intron -    22028664
chr12:105590465(-) A-I intron -    22028664
chr12:105590491(-) A-I intron -    22028664
chr12:105590494(-) A-I intron -    22028664
chr12:105589623(-) T-C intron -    22484847
chr12:105589686(-) T-C intron -    22484847
chr12:105594745(-) C-G intron -    22484847
chr12:105571593(-) T-C intron -    22484847
chr12:105571594(-) T-C intron -    22484847
chr12:105571686(-) T-C intron -    22484847
chr12:105571755(-) T-C intron -    22484847
chr12:105582820(-) T-C intron -    22484847
chr12:105582930(-) T-C intron -    22484847
chr12:105583068(-) T-G intron -    22484847
chr12:105589561(-) T-C intron -    22484847
chr12:105589615(-) A-G intron -    22484847
chr12:105589676(-) A-G intron -    22484847
chr12:105589689(-) A-G intron -    22484847
chr12:105589717(-) A-G intron -    22484847
chr12:105590343(-) T-C intron -    22484847
chr12:105590392(-) A-G intron -    22484847
chr12:105590439(-) T-C intron -    22484847
chr12:105590465(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase APPL2
chr12:105567931-105567932(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr12:105567944-105567945(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr12:105568062-105568063(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:105568118-105568119(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:105571023-105571024(-) m6A 3'UTR//CDS//exon       27773535
chr12:105583927-105583928(-) m6A 3'UTR//CDS//exon       24981863
chr12:105589058-105589059(-) m6A 3'UTR//CDS//exon       24981863
chr12:105589102-105589103(-) m6A 3'UTR//CDS//exon       24981863
chr12:105589249-105589250(-) m6A 3'UTR//CDS//exon       24981863
chr12:105589262-105589263(-) m6A 3'UTR//CDS//exon       24981863
chr12:105629776-105629777(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate APPL2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hcmv-miR-UL70-3p
l-685,458       5479543
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-UL70-3p
Interactor2: APPL2

Evidence Support:


Prediction-Evidence miRanda//RNAHybrid//Targetscan
Support Database VmiReg

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