Basic Information:

  VIRBase ID:  

VHID00245820

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-UL70-3p:  MIMAT0003343          MCM3:  NR_158966     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-UL70-3p	MCM3
miRBase Accession/Entrez ID	MIMAT0003343	4172
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCC5//P1-MCM3//P1.h//RLFB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MCM3	chr6:52130789(-) A-I      intronic chr6:52130159(-) A-I      Syn:Pro->Pro chr6:52139286(-) A-I      intronic chr6:52139834(-) A-I      intronic chr6:52139835(-) A-I      intronic chr6:52132596(-) A-I      intronic chr6:52139770(-) A-I      intronic chr6:52132519(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MCM3	chr6:52139835(-) A-G intron -    22484847 chr6:52139858(-) T-C intron -    22484847 chr6:52146208(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MCM3	chr6:52128834-52128835(-) m6A 3'UTR       27773535 chr6:52128865-52128866(-) Y 3'UTR       26075521 chr6:52128875-52128876(-) m6A 3'UTR       27773535 chr6:52128937-52128938(-) Cm 3'UTR       - chr6:52128990-52128991(-) m6A 3'UTR       24284625//24209618//27773535//22575960 chr6:52129097-52129098(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr6:52129163-52129164(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr6:52129176-52129177(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr6:52129226-52129227(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr6:52129235-52129236(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr6:52129367-52129368(-) m6A 3'UTR       24284625//24209618//27773535//27371828//27773536//22575960//22608085 chr6:52129441-52129442(-) Am 3'UTR//CDS       - chr6:52129488-52129489(-) m6A CDS       27773536//22575960 chr6:52130145-52130146(-) m6A CDS//intron       22575960 chr6:52130909-52130910(-) m6A CDS       24284625//24209618//27773535//27371828 chr6:52130920-52130921(-) m6A CDS       24284625//24209618//27773535//27371828 chr6:52131486-52131487(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960 chr6:52132683-52132684(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960 chr6:52132714-52132715(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960 chr6:52133938-52133939(-) m6A CDS       24209618//24981863//27773535//27371828//22575960 chr6:52133945-52133946(-) m6A CDS       24209618//24981863//27773535//27371828//22575960 chr6:52133993-52133994(-) m6A CDS       27773535//22575960 chr6:52134002-52134003(-) m6A CDS       27773535//22575960 chr6:52137108-52137109(-) m6A CDS       22575960 chr6:52138081-52138082(-) m6A CDS       22575960 chr6:52138592-52138593(-) m6A CDS       22575960 chr6:52138610-52138611(-) Am CDS       - chr6:52141867-52141868(-) m6A CDS//exon       22575960 chr6:52141875-52141876(-) m6A CDS//exon       22575960 chr6:52147650-52147651(-) m6A CDS       22575960 chr6:52148178-52148179(-) Am CDS//intron       - chr6:52148199-52148200(-) m6A CDS//intron       24284625//22575960 chr6:52149410-52149411(-) m6A CDS       24284625//22575960 chr6:52149514-52149515(-) m6A 5'UTR//CDS       24284625//24981863//27371828//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MCM3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-UL70-3p	l-685,458       5479543 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-UL70-3p
Interactor2: MCM3

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Rep//RNAHybrid//Targetscan
Support Database	RepTar//VmiReg