Basic Information:

  VIRBase ID:  

VHID00240862

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US4-5p:  MIMAT0003341          MAML1:  NM_014757     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US4-5p	MAML1
miRBase Accession/Entrez ID	MIMAT0003341	9794
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Mam-1//Mam1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAML1	chr5:179184067(+) A-I      intronic chr5:179184413(+) A-I      intronic chr5:179184422(+) A-I      intronic chr5:179182817(+) A-I      intronic chr5:179182835(+) A-I      intronic chr5:179178586(+) A-I      intronic chr5:179178617(+) A-I      intronic chr5:179178621(+) A-I      intronic chr5:179183017(+) A-I      intronic chr5:179178626(+) A-I      intronic chr5:179178627(+) A-I      intronic chr5:179178835(+) A-I      intronic chr5:179178938(+) A-I      intronic chr5:179181038(+) A-I      intronic chr5:179181198(+) A-I      intronic chr5:179181254(+) A-I      intronic chr5:179181263(+) A-I      intronic chr5:179183027(+) A-I      intronic chr5:179183254(+) A-I      intronic chr5:179181265(+) A-I      intronic chr5:179172673(+) A-I      intronic chr5:179196741(+) A-I      intronic chr5:179172470(+) A-I      intronic chr5:179169687(+) A-I      intronic chr5:179185742(+) A-I      intronic chr5:179172113(+) A-I      intronic chr5:179172007(+) A-I      intronic chr5:179170509(+) A-I      intronic chr5:179170507(+) A-I      intronic chr5:179170494(+) A-I      intronic chr5:179170485(+) A-I      intronic chr5:179170183(+) A-I      intronic chr5:179169767(+) A-I      intronic chr5:179169730(+) A-I      intronic chr5:179169653(+) A-I      intronic chr5:179169644(+) A-I      intronic chr5:179169617(+) A-I      intronic chr5:179169590(+) A-I      intronic chr5:179168466(+) A-I      intronic chr5:179167538(+) A-I      intronic chr5:179181448(+) A-I      intronic chr5:179185643(+) A-I      intronic chr5:179185754(+) A-I      intronic chr5:179167397(+) A-I      intronic chr5:179163919(+) A-I      intronic chr5:179163787(+) A-I      intronic chr5:179163777(+) A-I      intronic chr5:179163691(+) A-I      intronic chr5:179197355(+) A-I      intronic chr5:179163379(+) A-I      intronic chr5:179163371(+) A-I      intronic chr5:179163357(+) A-I      intronic chr5:179163354(+) A-I      intronic chr5:179163353(+) A-I      intronic chr5:179163334(+) A-I      intronic chr5:179161742(+) A-I      intronic chr5:179196816(+) A-I      intronic chr5:179172678(+) A-I      intronic chr5:179172674(+) A-I      intronic chr5:179173527(+) A-I      intronic chr5:179176392(+) A-I      intronic chr5:179174026(+) A-I      intronic chr5:179174556(+) A-I      intronic chr5:179174600(+) A-I      intronic chr5:179174673(+) A-I      intronic chr5:179176018(+) A-I      intronic chr5:179176028(+) A-I      intronic chr5:179176108(+) A-I      intronic chr5:179176262(+) A-I      intronic chr5:179176389(+) A-I      intronic chr5:179163380(+) A-I      intronic chr5:179177561(+) A-I      intronic chr5:179177562(+) A-I      intronic chr5:179177601(+) A-I      intronic chr5:179177631(+) A-I      intronic chr5:179177701(+) A-I      intronic chr5:179183260(+) A-I      intronic chr5:179162818(+) A-I      intronic chr5:179183275(+) A-I      intronic chr5:179183970(+) A-I      intronic chr5:179184003(+) A-I      intronic chr5:179184012(+) A-I      intronic chr5:179184063(+) A-I      intronic chr5:179178092(+) A-I      intronic chr5:179178455(+) A-I      intronic chr5:179178530(+) A-I      intronic chr5:179178541(+) A-I      intronic chr5:179178547(+) A-I      intronic chr5:179178553(+) A-I      intronic chr5:179178579(+) A-I      intronic chr5:179199386(+) A-I      intronic chr5:179168602(+) A-I      intronic chr5:179174664(+) A-I      intronic chr5:179172042(+) A-I      intronic chr5:179177671(+) A-I      intronic chr5:179173487(+) A-I      intronic chr5:179179141(+) A-I      intronic chr5:179168923(+) A-I      intronic chr5:179196763(+) A-I      intronic chr5:179178946(+) A-I      intronic chr5:179162878(+) A-I      intronic chr5:179168566(+) A-I      intronic chr5:179175163(+) A-I      intronic chr5:179161733(+) A-I      intronic chr5:179168553(+) A-I      intronic chr5:179169681(+) A-I      intronic chr5:179173253(+) A-I      intronic chr5:179171718(+) A-I      intronic chr5:179163310(+) A-I      intronic chr5:179177591(+) A-I      intronic chr5:179183276(+) A-I      intronic chr5:179166634(+) A-I      intronic chr5:179176310(+) A-I      intronic chr5:179166617(+) A-I      intronic chr5:179171423(+) A-I      intronic chr5:179168999(+) A-I      intronic chr5:179180908(+) A-I      intronic chr5:179169642(+) A-I      intronic chr5:179181414(+) A-I      intronic chr5:179181346(+) A-I      intronic chr5:179183274(+) A-I      intronic chr5:179169628(+) A-I      intronic chr5:179166281(+) A-I      intronic chr5:179176106(+) A-I      intronic chr5:179197338(+) A-I      intronic chr5:179174089(+) A-I      intronic chr5:179174122(+) A-I      intronic chr5:179185518(+) A-I      intronic chr5:179185537(+) A-I      intronic chr5:179181184(+) A-I      intronic chr5:179175283(+) A-I      intronic chr5:179170556(+) A-I      intronic chr5:179169563(+) A-I      intronic chr5:179183239(+) A-I      intronic chr5:179178002(+) A-I      intronic chr5:179168580(+) A-I      intronic chr5:179199213(+) A-I      intronic chr5:179163798(+) A-I      intronic chr5:179197396(+) A-I      intronic chr5:179185884(+) A-I      intronic chr5:179181109(+) A-I      intronic chr5:179170171(+) A-I      intronic chr5:179178461(+) A-I      intronic chr5:179172989(+) A-I      intronic chr5:179169240(+) A-I      intronic chr5:179169597(+) A-I      intronic chr5:179172032(+) A-I      intronic chr5:179173514(+) A-I      intronic chr5:179173171(+) A-I      intronic chr5:179199325(+) A-I      intronic chr5:179170596(+) A-I      intronic chr5:179183367(+) A-I      intronic chr5:179196797(+) A-I      intronic chr5:179161875(+) A-I      intronic chr5:179173182(+) A-I      intronic chr5:179163707(+) A-I      intronic chr5:179178836(+) A-I      intronic chr5:179168608(+) A-I      intronic chr5:179169661(+) A-I      intronic chr5:179173200(+) A-I      intronic chr5:179185510(+) A-I      intronic chr5:179168500(+) A-I      intronic chr5:179173185(+) A-I      intronic chr5:179196719(+) A-I      intronic chr5:179197192(+) A-I      intronic chr5:179174626(+) A-I      intronic chr5:179176096(+) A-I      intronic chr5:179196828(+) A-I      intronic chr5:179181443(+) A-I      intronic chr5:179180840(+) A-I      intronic chr5:179173516(+) A-I      intronic chr5:179197195(+) A-I      intronic chr5:179183995(+) A-I      intronic chr5:179181120(+) A-I      intronic chr5:179175223(+) A-I      intronic chr5:179199349(+) A-I      intronic chr5:179164875(+) A-I      intronic chr5:179183376(+) A-I      intronic chr5:179167389(+) A-I      intronic chr5:179181086(+) A-I      intronic chr5:179181442(+) A-I      intronic chr5:179166618(+) A-I      intronic chr5:179175183(+) A-I      intronic chr5:179199140(+) A-I      intronic chr5:179185845(+) A-I      intronic chr5:179169645(+) A-I      intronic chr5:179181267(+) A-I      intronic chr5:179176427(+) A-I      intronic chr5:179174557(+) A-I      intronic chr5:179185565(+) A-I      intronic chr5:179196609(+) A-I      intronic chr5:179196671(+) A-I      intronic chr5:179185577(+) A-I      intronic chr5:179169740(+) A-I      intronic chr5:179178811(+) A-I      intronic chr5:179171470(+) A-I      intronic chr5:179175357(+) A-I      intronic chr5:179184018(+) A-I      intronic chr5:179196579(+) A-I      intronic chr5:179183272(+) A-I      intronic chr5:179169542(+) A-I      intronic chr5:179187837(+) A-I      intronic chr5:179169054(+) A-I      intronic chr5:179183269(+) A-I      intronic chr5:179181176(+) A-I      intronic chr5:179181578(+) A-I      intronic chr5:179177607(+) A-I      intronic chr5:179185803(+) A-I      intronic chr5:179173636(+) A-I      intronic chr5:179170578(+) A-I      intronic chr5:179169643(+) A-I      intronic chr5:179175115(+) A-I      intronic chr5:179163434(+) A-I      intronic chr5:179183347(+) A-I      intronic chr5:179165875(+) A-I      intronic chr5:179181535(+) A-I      intronic chr5:179185491(+) A-I      intronic chr5:179163785(+) A-I      intronic chr5:179168637(+) A-I      intronic chr5:179161792(+) A-I      intronic chr5:179199392(+) A-I      intronic chr5:179176257(+) A-I      intronic chr5:179182784(+) A-I      intronic chr5:179180048(+) A-I      intronic chr5:179191550(+) A-I      intronic chr5:179181014(+) A-I      intronic chr5:179178559(+) A-I      intronic chr5:179182900(+) A-I      intronic chr5:179170442(+) A-I      intronic chr5:179165911(+) A-I      intronic chr5:179163816(+) A-I      intronic chr5:179168502(+) A-I      intronic chr5:179167551(+) A-I      intronic chr5:179163276(+) A-I      intronic chr5:179183328(+) A-I      intronic chr5:179163437(+) A-I      intronic chr5:179171706(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAML1	chr5:179166588(+) A-I intron -    21960545 chr5:179162728(+) A-G intron -    22484847 chr5:179162878(+) A-G intron -    22484847 chr5:179163310(+) A-G intron -    22484847 chr5:179163785(+) A-G intron -    22484847 chr5:179163798(+) A-G intron -    22484847 chr5:179163816(+) A-G intron -    22484847 chr5:179163901(+) A-G intron -    22484847 chr5:179167389(+) A-G intron -    22484847 chr5:179168553(+) A-G intron -    22484847 chr5:179168593(+) A-G intron -    22484847 chr5:179168602(+) A-G intron -    22484847 chr5:179168919(+) A-G intron -    22484847 chr5:179168923(+) A-G intron -    22484847 chr5:179168999(+) A-G intron -    22484847 chr5:179169054(+) A-G intron -    22484847 chr5:179169240(+) A-G intron -    22484847 chr5:179169681(+) A-G intron -    22484847 chr5:179169688(+) A-G intron -    22484847 chr5:179170171(+) A-G intron -    22484847 chr5:179170442(+) A-G intron -    22484847 chr5:179170556(+) A-G intron -    22484847 chr5:179170578(+) A-G intron -    22484847 chr5:179170596(+) A-G intron -    22484847 chr5:179171423(+) A-G intron -    22484847 chr5:179172032(+) A-G intron -    22484847 chr5:179172044(+) A-G intron -    22484847 chr5:179173487(+) A-G intron -    22484847 chr5:179173514(+) A-G intron -    22484847 chr5:179173516(+) A-G intron -    22484847 chr5:179174025(+) A-G intron -    22484847 chr5:179176245(+) A-G intron -    22484847 chr5:179178461(+) A-G intron -    22484847 chr5:179178559(+) A-G intron -    22484847 chr5:179178811(+) A-G intron -    22484847 chr5:179178836(+) A-G intron -    22484847 chr5:179178878(+) A-G intron -    22484847 chr5:179178884(+) A-G intron -    22484847 chr5:179181086(+) A-G intron -    22484847 chr5:179181109(+) A-G intron -    22484847 chr5:179181578(+) A-G intron -    22484847 chr5:179182900(+) A-G intron -    22484847 chr5:179183239(+) A-G intron -    22484847 chr5:179183273(+) A-G intron -    22484847 chr5:179183274(+) A-G intron -    22484847 chr5:179183995(+) A-G intron -    22484847 chr5:179185491(+) A-G intron -    22484847 chr5:179185746(+) A-G intron -    22484847 chr5:179185803(+) A-G intron -    22484847 chr5:179185845(+) A-G intron -    22484847 chr5:179185940(+) A-G intron -    22484847 chr5:179196671(+) A-G intron -    22484847 chr5:179199212(+) T-C intron -    22484847 chr5:179199213(+) A-G intron -    22484847 chr5:179199226(+) T-C intron -    22484847 chr5:179199386(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAML1	chr5:179159873-179159874(+) m6A 5'UTR       24981863 chr5:179159963-179159964(+) m6A 5'UTR       24209618//24981863 chr5:179192405-179192406(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr5:179192428-179192429(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr5:179192472-179192473(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192561-179192562(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192655-179192656(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192678-179192679(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192701-179192702(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192738-179192739(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192786-179192787(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192807-179192808(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192816-179192817(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192831-179192832(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192849-179192850(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192878-179192879(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192894-179192895(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192940-179192941(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179192983-179192984(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr5:179193046-179193047(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr5:179193080-179193081(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr5:179193095-179193096(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr5:179193251-179193252(+) m6A CDS//exon       24284625//22575960 chr5:179193383-179193384(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr5:179193399-179193400(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr5:179193473-179193474(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179193512-179193513(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179193542-179193543(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179193558-179193559(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179193581-179193582(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179193674-179193675(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179195857-179195858(+) m6A CDS//exon       24284625//24981863//22575960 chr5:179195901-179195902(+) m6A CDS//exon       24284625//22575960 chr5:179196004-179196005(+) m6A CDS//exon       24284625 chr5:179196014-179196015(+) m6A CDS//exon       24284625 chr5:179196086-179196087(+) m6A CDS//exon       24284625 chr5:179197936-179197937(+) m6A exon//intron       24284625 chr5:179197998-179197999(+) m6A exon//intron       24284625 chr5:179198199-179198200(+) m6A CDS//exon       24284625 chr5:179198233-179198234(+) m6A CDS//exon       24284625 chr5:179200922-179200923(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179200998-179200999(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201027-179201028(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201042-179201043(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201075-179201076(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:179201157-179201158(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201179-179201180(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201195-179201196(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201225-179201226(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201269-179201270(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201276-179201277(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201363-179201364(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:179201377-179201378(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:179201387-179201388(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:179201560-179201561(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr5:179201719-179201720(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr5:179201790-179201791(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:179201822-179201823(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:179201827-179201828(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:179201958-179201959(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr5:179203035-179203036(+) m6A 3'UTR//intron       24981863//22608085 chr5:179203060-179203061(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:179203121-179203122(+) Am 3'UTR//intron       - chr5:179203176-179203177(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:179203251-179203252(+) m6A 3'UTR//intron       24284625//22608085 chr5:179203435-179203436(+) m6A 3'UTR//intron       24284625 chr5:179203503-179203504(+) m6A 3'UTR//intron       24284625//24981863 chr5:179203862-179203863(+) m6A 3'UTR//intron       24284625//24981863 chr5:179203956-179203957(+) m6A 3'UTR//intron       24981863 chr5:179220161-179220162(+) m6A exon       25456834 chr5:179222791-179222792(+) m6A exon       - chr5:179223396-179223397(+) m6A exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hcmv-miR-US4-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
	MAML1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US4-5p
Interactor2: MAML1

Evidence Support:

Prediction-Evidence	miRanda//PITA//Targetscan
Support Database	VmiReg