Basic Information:

  VIRBase ID:  

VHID00238041

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US33-5p:  MIMAT0001584          TMEM138:  NR_028473     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US33-5p	TMEM138
miRBase Accession/Entrez ID	MIMAT0001584	51524
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC196

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM138	chr11:61132850(+) A-I      intronic chr11:61132988(+) A-I      intronic chr11:61132764(+) A-I      intronic chr11:61132872(+) A-I      intronic chr11:61132575(+) A-I      intronic chr11:61132489(+) A-I      intronic chr11:61132426(+) A-I      intronic chr11:61132832(+) A-I      intronic chr11:61132371(+) A-I      intronic chr11:61132963(+) A-I      intronic chr11:61132123(+) A-I      intronic chr11:61133129(+) A-I      intronic chr11:61132287(+) A-I      intronic chr11:61133106(+) A-I      intronic chr11:61132180(+) A-I      intronic chr11:61132813(+) A-I      intronic chr11:61132934(+) A-I      intronic chr11:61132862(+) A-I      intronic chr11:61132859(+) A-I      intronic chr11:61132874(+) A-I      intronic chr11:61132099(+) A-I      intronic chr11:61132132(+) A-I      intronic chr11:61132989(+) A-I      intronic chr11:61132786(+) A-I      intronic chr11:61132937(+) A-I      intronic chr11:61132836(+) A-I      intronic chr11:61132411(+) A-I      intronic chr11:61133001(+) A-I      intronic chr11:61133097(+) A-I      intronic chr11:61132306(+) A-I      intronic chr11:61132928(+) A-I      intronic chr11:61132247(+) A-I      intronic chr11:61132911(+) A-I      intronic chr11:61132127(+) A-I      intronic chr11:61132171(+) A-I      intronic chr11:61132454(+) A-I      intronic chr11:61132833(+) A-I      intronic chr11:61132445(+) A-I      intronic chr11:61133057(+) A-I      intronic chr11:61132939(+) A-I      intronic chr11:61133015(+) A-I      intronic chr11:61132224(+) A-I      intronic chr11:61132642(+) A-I      intronic chr11:61132484(+) A-I      intronic chr11:61132540(+) A-I      intronic chr11:61132474(+) A-I      intronic chr11:61132837(+) A-I      intronic chr11:61132286(+) A-I      intronic chr11:61132644(+) A-I      intronic chr11:61133186(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM138	chr11:61132099(+) A-G intron -    22484847 chr11:61132180(+) A-G intron -    22484847 chr11:61132286(+) A-G intron -    22484847 chr11:61132287(+) A-G intron -    22484847 chr11:61132306(+) A-G intron -    22484847 chr11:61132644(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM138	chr11:61129536-61129537(+) m6A 5'UTR       25456834//24981863//27773536//22608085 chr11:61129715-61129716(+) m6A 5'UTR       24284625//24981863 chr11:61129743-61129744(+) m6A 5'UTR       24981863 chr11:61129775-61129776(+) m6A 5'UTR       24981863 chr11:61131746-61131747(+) m6A 5'UTR//exon       24981863 chr11:61131765-61131766(+) m6A 5'UTR//exon       24981863 chr11:61131795-61131796(+) m6A 5'UTR//exon//intron       24284625//24981863//22608085 chr11:61131819-61131820(+) m6A 5'UTR//exon//intron       24284625//24981863//22608085 chr11:61131851-61131852(+) m6A 5'UTR//exon//intron       24284625//24981863//22608085 chr11:61131871-61131872(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr11:61131948-61131949(+) m6A CDS//exon//intron       24284625//22608085 chr11:61131961-61131962(+) m6A CDS//exon//intron       24284625//22608085 chr11:61132021-61132022(+) m6A exon//intron       24284625//22608085 chr11:61132113-61132114(+) m6A exon//intron       24284625 chr11:61133450-61133451(+) m6A 5'UTR//intron       - chr11:61133628-61133629(+) m6A CDS//exon       24284625 chr11:61136100-61136101(+) m6A CDS//exon//intron       24284625//24981863 chr11:61136111-61136112(+) m6A CDS//exon//intron       24284625//24981863 chr11:61136137-61136138(+) m6A CDS//exon//intron       24284625//24981863 chr11:61136269-61136270(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960 chr11:61136277-61136278(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960 chr11:61136297-61136298(+) m6A 3'UTR//exon       24284625//24209618//24981863 chr11:61136513-61136514(+) m6A 3'UTR//exon       24284625//27773535 chr11:61136521-61136522(+) m6A 3'UTR//exon       24284625//27773535 chr11:61136604-61136605(+) m6A 3'UTR//exon       24284625//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TMEM138	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US33-5p
Interactor2: TMEM138

Evidence Support:

Prediction-Evidence	miRanda//Targetscan
Support Database	VmiReg