Basic Information:

  VIRBase ID:  

VHID00235664

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-2-3p:  MIMAT0001583          NLRP3:  NM_001243133     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-2-3p	NLRP3
miRBase Accession/Entrez ID	MIMAT0001583	114548
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AGTAVPRL//AII//AVP//C1orf7//CIAS1//CLR1.1//DFNA34//FCAS//FCAS1//FCU//KEFH//MWS//NALP3//PYPAF1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NLRP3	chr1:247606606(+) A-I      intronic chr1:247595377(+) A-I      intronic chr1:247594186(+) A-I      intronic chr1:247594098(+) A-I      intronic chr1:247594138(+) A-I      intronic chr1:247606109(+) A-I      intronic chr1:247595396(+) A-I      intronic chr1:247594094(+) A-I      intronic chr1:247596375(+) A-I      intronic chr1:247594162(+) A-I      intronic chr1:247595316(+) A-I      intronic chr1:247594181(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NLRP3	chr1:247582008-247582009(+) m6A 5'UTR//exon//intron       - chr1:247582020-247582021(+) m6A 5'UTR//exon//intron       - chr1:247582063-247582064(+) m6A 5'UTR//exon       - chr1:247582077-247582078(+) m6A 5'UTR//exon       - chr1:247582086-247582087(+) m6A 5'UTR//exon       - chr1:247582142-247582143(+) m6A CDS//exon       - chr1:247582157-247582158(+) m6A CDS//exon       - chr1:247582187-247582188(+) m6A CDS//exon       - chr1:247582231-247582232(+) m6A CDS//exon       - chr1:247582244-247582245(+) m6A CDS//exon       - chr1:247582340-247582341(+) m6A CDS//exon       - chr1:247586579-247586580(+) m6A CDS//exon       - chr1:247587321-247587322(+) m6A CDS//exon       - chr1:247587441-247587442(+) m6A CDS//exon       - chr1:247587469-247587470(+) m6A CDS//exon       - chr1:247587483-247587484(+) m6A CDS//exon       - chr1:247587496-247587497(+) m6A CDS//exon       - chr1:247587565-247587566(+) m6A CDS//exon       - chr1:247587595-247587596(+) m6A CDS//exon       - chr1:247587623-247587624(+) m6A CDS//exon       - chr1:247587692-247587693(+) m6A CDS//exon       - chr1:247587730-247587731(+) m6A CDS//exon       - chr1:247587797-247587798(+) m6A CDS//exon       - chr1:247587815-247587816(+) m6A CDS//exon       - chr1:247587832-247587833(+) m6A CDS//exon       - chr1:247588007-247588008(+) m6A CDS//exon       - chr1:247588013-247588014(+) m6A CDS//exon       - chr1:247588047-247588048(+) m6A CDS//exon       - chr1:247588056-247588057(+) m6A CDS//exon       - chr1:247588180-247588181(+) m6A CDS//exon       - chr1:247588223-247588224(+) m6A CDS//exon       - chr1:247588261-247588262(+) m6A CDS//exon       - chr1:247588282-247588283(+) m6A CDS//exon       - chr1:247588435-247588436(+) m6A CDS//exon       - chr1:247588498-247588499(+) m6A CDS//exon       - chr1:247588509-247588510(+) m6A CDS//exon       - chr1:247588666-247588667(+) m6A CDS//exon       - chr1:247588687-247588688(+) m6A CDS//exon       - chr1:247588729-247588730(+) m6A CDS//exon       - chr1:247588759-247588760(+) m6A CDS//exon       - chr1:247588909-247588910(+) m6A exon//intron       - chr1:247611898-247611899(+) m6A 3'UTR       - chr1:247612003-247612004(+) m6A 3'UTR       - chr1:247612011-247612012(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NLRP3	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US25-2-3p	Irinotecan       60838

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-2-3p
Interactor2: NLRP3

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//RNAHybrid//Targetscan
Support Database	RepTar//VmiReg