Basic Information:

  VIRBase ID:  

VHID00235569

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-2-3p:  MIMAT0001583          OTULIN:  NM_138348     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-2-3p	OTULIN
miRBase Accession/Entrez ID	MIMAT0001583	90268
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIPDS//FAM105B//GUM

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OTULIN	chr5:14667507(+) A-I      intronic chr5:14667607(+) A-I      intronic chr5:14667594(+) A-I      intronic chr5:14667567(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OTULIN	chr5:14664910-14664911(+) m6A 5'UTR//exon       24209618 chr5:14664946-14664947(+) m6A CDS//exon       24209618 chr5:14673758-14673759(+) m6A CDS//exon//intron       24209618//24981863 chr5:14678840-14678841(+) Am 3'UTR//CDS       - chr5:14681699-14681700(+) m6A 3'UTR//CDS//exon       24284625//24209618 chr5:14687640-14687641(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618 chr5:14687676-14687677(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//22575960//22608085 chr5:14687682-14687683(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//22575960//22608085 chr5:14687708-14687709(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr5:14687762-14687763(+) m6A exon//intron       24284625//24209618//24981863//22575960//22608085 chr5:14687818-14687819(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:14688012-14688013(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:14690171-14690172(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085 chr5:14690185-14690186(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085 chr5:14690203-14690204(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr5:14690265-14690266(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:14690278-14690279(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr5:14690343-14690344(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr5:14690362-14690363(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr5:14690376-14690377(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085 chr5:14690395-14690396(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr5:14690413-14690414(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr5:14693074-14693075(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:14693145-14693146(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:14693245-14693246(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr5:14693261-14693262(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr5:14693289-14693290(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr5:14693305-14693306(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr5:14693405-14693406(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr5:14693448-14693449(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14693492-14693493(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14693509-14693510(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14693605-14693606(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14693621-14693622(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14693769-14693770(+) m6A 3'UTR       24209618//24981863 chr5:14693863-14693864(+) m6A 3'UTR       24209618//24981863 chr5:14693895-14693896(+) m6A 3'UTR       24209618 chr5:14693902-14693903(+) m6A 3'UTR       24209618 chr5:14694480-14694481(+) m6A 3'UTR       24284625 chr5:14694502-14694503(+) m6A 3'UTR       24284625 chr5:14694509-14694510(+) m6A 3'UTR       24284625 chr5:14696903-14696904(+) m6A 3'UTR       - chr5:14698616-14698617(+) m6A 3'UTR       24284625 chr5:14698654-14698655(+) m6A 3'UTR       24284625//24981863 chr5:14698669-14698670(+) m6A 3'UTR       24284625//24981863 chr5:14698678-14698679(+) m6A 3'UTR       24284625//24981863 chr5:14698696-14698697(+) m6A 3'UTR       24284625//24981863 chr5:14698758-14698759(+) m6A 3'UTR       24284625 chr5:14698815-14698816(+) m6A 3'UTR       24284625 chr5:14699243-14699244(+) m6A 3'UTR       24284625 chr5:14699257-14699258(+) m6A 3'UTR       24284625 chr5:14699302-14699303(+) m6A 3'UTR       24284625//24209618//22608085 chr5:14699368-14699369(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14699373-14699374(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14699446-14699447(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr5:14699491-14699492(+) m6A 3'UTR       24284625//24209618 chr5:14699557-14699558(+) m6A 3'UTR       24284625//24209618 chr5:14699572-14699573(+) m6A 3'UTR       24284625//24209618 chr5:14699579-14699580(+) m6A 3'UTR       24284625 chr5:14699693-14699694(+) m6A 3'UTR       24284625 chr5:14699754-14699755(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OTULIN	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US25-2-3p	Irinotecan       60838

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-2-3p
Interactor2: OTULIN

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Rep//Targetscan
Support Database	RepTar//VmiReg