Basic Information:

  VIRBase ID:  

VHID00228557

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-2-3p:  MIMAT0001580          PFKFB2:  NM_006212     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-2-3p	PFKFB2
miRBase Accession/Entrez ID	MIMAT0001580	5208
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PFK-2/FBPase-2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PFKFB2	chr1:207235177(+) A-I      intronic chr1:207232020(+) A-I      intronic chr1:207232083(+) A-I      intronic chr1:207232060(+) A-I      intronic chr1:207234605(+) A-I      intronic chr1:207232101(+) A-I      intronic chr1:207235106(+) A-I      intronic chr1:207235021(+) A-I      intronic chr1:207235169(+) A-I      intronic chr1:207230537(+) A-I      intronic chr1:207235018(+) A-I      intronic chr1:207243860(+) A-I      intronic chr1:207232012(+) A-I      intronic chr1:207230839(+) A-I      intronic chr1:207234973(+) A-I      intronic chr1:207232029(+) A-I      intronic chr1:207249019(+) A-I      3'UTR chr1:207230538(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PFKFB2	chr1:207235018(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PFKFB2	chr1:207222533-207222534(+) m6A exon//intron       - chr1:207222635-207222636(+) m6A exon//intron       - chr1:207222893-207222894(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27371828//22575960//22608085 chr1:207222950-207222951(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27371828//22575960//22608085 chr1:207244895-207244896(+) m6A 3'UTR//CDS//exon       24284625 chr1:207245564-207245565(+) m6A CDS//intron       24284625 chr1:207245569-207245570(+) m6A CDS//intron       24284625 chr1:207245591-207245592(+) m6A CDS//intron       24284625 chr1:207245693-207245694(+) m6A CDS//intron       24284625//24209618//24981863 chr1:207245722-207245723(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr1:207245863-207245864(+) m6A 3'UTR//intron       24284625//24981863 chr1:207245886-207245887(+) m6A 3'UTR//intron       24981863 chr1:207245913-207245914(+) m6A 3'UTR//intron       24981863 chr1:207252446-207252447(+) m6A 3'UTR//exon       24284625//25456834//24981863 chr1:207252464-207252465(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr1:207252469-207252470(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr1:207252580-207252581(+) m6A 3'UTR//exon       24284625//22608085 chr1:207252596-207252597(+) m6A 3'UTR//exon       24284625//22608085 chr1:207253623-207253624(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PFKFB2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-2-3p
Interactor2: PFKFB2

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//VmiReg