Basic Information:

  VIRBase ID:  

VHID00227877

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          PRIMA1:  NM_178013     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	PRIMA1
miRBase Accession/Entrez ID	MIMAT0001579	145270
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRIMA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRIMA1	chr14:94224869(-) A-I      intronic chr14:94243791(-) A-I      intronic chr14:94191495(-) A-I      intronic chr14:94193785(-) A-I      intronic chr14:94243820(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRIMA1	chr14:94186976-94186977(-) m6A 3'UTR       25456834//24981863 chr14:94187004-94187005(-) m6A 3'UTR       25456834//24981863 chr14:94187058-94187059(-) m6A 3'UTR       25456834//24981863 chr14:94187122-94187123(-) m6A 3'UTR       25456834//24981863 chr14:94187595-94187596(-) m6A 3'UTR       25456834//24981863//27773536 chr14:94187649-94187650(-) m6A 3'UTR       25456834//24981863 chr14:94187689-94187690(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187717-94187718(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187735-94187736(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187756-94187757(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187773-94187774(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187805-94187806(-) m6A 3'UTR//CDS       25456834//24981863//22608085 chr14:94187888-94187889(-) m6A 3'UTR//CDS       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PRIMA1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: PRIMA1

Evidence Support:

Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VmiReg