Basic Information:

  VIRBase ID:  

VHID00227848

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          MTPN:  NM_145808     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	MTPN
miRBase Accession/Entrez ID	MIMAT0001579	136319
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCDP//V-1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTPN	chr7:135614483-135614484(-) m6A 3'UTR       24284625 chr7:135614661-135614662(-) m6A 3'UTR       24284625 chr7:135662037-135662038(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536 chr7:135662069-135662070(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MTPN	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: MTPN

Evidence Support:

Prediction-Evidence	cRep//miRanda
Support Database	RepTar//VmiReg