Basic Information:

  VIRBase ID:  

VHID00227775

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          NUS1:  NM_138459     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	NUS1
miRBase Accession/Entrez ID	MIMAT0001579	116150
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C6orf68//CDG1AA//MGC:7199//MRD55//NgBR//TANGO14

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUS1	chr6:118010914(+) A-I      intronic chr6:118010918(+) A-I      intronic chr6:118010886(+) A-I      intronic chr6:118026812(+) A-I      intronic chr6:118026813(+) A-I      intronic chr6:118026821(+) A-I      intronic chr6:118010938(+) A-I      intronic chr6:118016162(+) A-I      intronic chr6:118016218(+) A-I      intronic chr6:118016193(+) A-I      intronic chr6:118016203(+) A-I      intronic chr6:118016179(+) A-I      intronic chr6:118006796(+) A-I      intronic chr6:118007170(+) A-I      intronic chr6:118007272(+) A-I      intronic chr6:118007277(+) A-I      intronic chr6:118007301(+) A-I      intronic chr6:118010749(+) A-I      intronic chr6:118003015(+) A-I      intronic chr6:117999958(+) A-I      intronic chr6:117999944(+) A-I      intronic chr6:117997647(+) A-I      intronic chr6:118007303(+) A-I      intronic chr6:118006777(+) A-I      intronic chr6:118016111(+) A-I      intronic chr6:118003122(+) A-I      intronic chr6:118003679(+) A-I      intronic chr6:118006565(+) A-I      intronic chr6:118003486(+) A-I      intronic chr6:118003180(+) A-I      intronic chr6:118003100(+) A-I      intronic chr6:118016283(+) A-I      intronic chr6:118006651(+) A-I      intronic chr6:118006573(+) A-I      intronic chr6:118010794(+) A-I      intronic chr6:117997630(+) A-I      intronic chr6:118009292(+) A-I      intronic chr6:118022512(+) A-I      intronic chr6:118010943(+) A-I      intronic chr6:118003581(+) A-I      intronic chr6:118003269(+) A-I      intronic chr6:118010751(+) A-I      intronic chr6:117997586(+) A-I      intronic chr6:118010770(+) A-I      intronic chr6:118010950(+) A-I      intronic chr6:117997566(+) A-I      intronic chr6:118016102(+) A-I      intronic chr6:118012035(+) A-I      intronic chr6:118003143(+) A-I      intronic chr6:118003657(+) A-I      intronic chr6:118009304(+) A-I      intronic chr6:118006621(+) A-I      intronic chr6:118003643(+) A-I      intronic chr6:118009198(+) A-I      intronic chr6:118003135(+) A-I      intronic chr6:118003521(+) A-I      intronic chr6:118016307(+) A-I      intronic chr6:118003070(+) A-I      intronic chr6:118006663(+) A-I      intronic chr6:118006735(+) A-I      intronic chr6:118022606(+) A-I      intronic chr6:118016320(+) A-I      intronic chr6:118010811(+) A-I      intronic chr6:118009177(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUS1	chr6:117999908(+) A-G intron -    22484847 chr6:118003070(+) A-G intron -    22484847 chr6:118003125(+) A-G intron -    22484847 chr6:118003135(+) A-G intron -    22484847 chr6:118003143(+) A-G intron -    22484847 chr6:118003185(+) T-C intron -    22484847 chr6:118003269(+) A-G intron -    22484847 chr6:118003521(+) A-G intron -    22484847 chr6:118003643(+) A-G intron -    22484847 chr6:118006573(+) A-G intron -    22484847 chr6:118006611(+) A-G intron -    22484847 chr6:118006651(+) A-G intron -    22484847 chr6:118006661(+) A-G intron -    22484847 chr6:118006704(+) A-G intron -    22484847 chr6:118009177(+) A-G intron -    22484847 chr6:118009197(+) A-G intron -    22484847 chr6:118009292(+) A-G intron -    22484847 chr6:118010751(+) A-G intron -    22484847 chr6:118010770(+) A-G intron -    22484847 chr6:118010799(+) A-G intron -    22484847 chr6:118010837(+) A-G intron -    22484847 chr6:118010943(+) A-G intron -    22484847 chr6:118012009(+) A-G intron -    22484847 chr6:118016102(+) A-G intron -    22484847 chr6:118016103(+) A-G intron -    22484847 chr6:118016250(+) A-G intron -    22484847 chr6:118022477(+) A-G intron -    22484847 chr6:118022512(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUS1	chr6:117996933-117996934(+) m6A CDS       24209618 chr6:118015268-118015269(+) m6A CDS       24284625//24981863//22608085 chr6:118015302-118015303(+) m6A CDS       24284625//24981863//22608085 chr6:118024818-118024819(+) m6A CDS       24284625//22608085 chr6:118028107-118028108(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:118028122-118028123(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:118028159-118028160(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr6:118028224-118028225(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr6:118028260-118028261(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr6:118028304-118028305(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr6:118028391-118028392(+) m6A 3'UTR       24981863//22608085 chr6:118028430-118028431(+) m6A 3'UTR       24981863 chr6:118028468-118028469(+) m6A 3'UTR       24981863 chr6:118028542-118028543(+) m6A 3'UTR       24981863 chr6:118029081-118029082(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NUS1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: NUS1

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//VmiReg