Basic Information:

  VIRBase ID:  

VHID00227496

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          ZFYVE21:  NM_001198953     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	ZFYVE21
miRBase Accession/Entrez ID	MIMAT0001579	79038
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCVP7TP1//ZF21

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE21	chr14:104185726(+) A-I      intronic chr14:104189052(+) A-I      intronic chr14:104188778(+) A-I      intronic chr14:104188792(+) A-I      intronic chr14:104188893(+) A-I      intronic chr14:104188973(+) A-I      intronic chr14:104185721(+) A-I      intronic chr14:104193483(+) A-I      intronic chr14:104185650(+) A-I      intronic chr14:104185713(+) A-I      intronic chr14:104193492(+) A-I      intronic chr14:104185741(+) A-I      intronic chr14:104193480(+) A-I      intronic chr14:104189097(+) A-I      intronic chr14:104197432(+) A-I      intronic chr14:104188901(+) A-I      intronic chr14:104189035(+) A-I      intronic chr14:104189176(+) A-I      intronic chr14:104189261(+) A-I      intronic chr14:104188818(+) A-I      intronic chr14:104187260(+) A-I      intronic chr14:104188759(+) A-I      intronic chr14:104187183(+) A-I      intronic chr14:104187259(+) A-I      intronic chr14:104188831(+) A-I      intronic chr14:104185780(+) A-I      intronic chr14:104187277(+) A-I      intronic chr14:104188748(+) A-I      intronic chr14:104189101(+) A-I      intronic chr14:104197437(+) A-I      intronic chr14:104188902(+) A-I      intronic chr14:104188821(+) A-I      intronic chr14:104185686(+) A-I      intronic chr14:104188715(+) A-I      intronic chr14:104185494(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZFYVE21	chr14:104197572(+) A-I intron -    21960545 chr14:104197527(+) G-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE21	chr14:104191030-104191031(+) m6A exon//intron       - chr14:104199347-104199348(+) m6A CDS//exon       24981863 chr14:104199396-104199397(+) m6A 3'UTR//exon       24981863 chr14:104199411-104199412(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZFYVE21	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: ZFYVE21

Evidence Support:

Prediction-Evidence	miRanda//Targetscan
Support Database	VmiReg