Basic Information:

  VIRBase ID:  

VHID00227296

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          KLHL7:  NR_033329     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	KLHL7
miRBase Accession/Entrez ID	MIMAT0001579	55975
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CISS3//KLHL6//PERCHING//SBBI26

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL7	chr7:23176781(+) A-I      intronic chr7:23176761(+) A-I      intronic chr7:23159066(+) A-I      intronic chr7:23158509(+) A-I      intronic chr7:23158495(+) A-I      intronic chr7:23208655(+) A-I      intronic chr7:23155349(+) A-I      intronic chr7:23160407(+) A-I      intronic chr7:23176697(+) A-I      intronic chr7:23153212(+) A-I      intronic chr7:23151406(+) A-I      intronic chr7:23151334(+) A-I      intronic chr7:23151320(+) A-I      intronic chr7:23151269(+) A-I      intronic chr7:23210620(+) A-I      intronic chr7:23155256(+) A-I      intronic chr7:23210684(+) A-I      intronic chr7:23208606(+) A-I      intronic chr7:23208670(+) A-I      intronic chr7:23160368(+) A-I      intronic chr7:23208701(+) A-I      intronic chr7:23208702(+) A-I      intronic chr7:23208724(+) A-I      intronic chr7:23208625(+) A-I      intronic chr7:23160394(+) A-I      intronic chr7:23208727(+) A-I      intronic chr7:23197824(+) A-I      intronic chr7:23197821(+) A-I      intronic chr7:23185602(+) A-I      intronic chr7:23177398(+) A-I      intronic chr7:23177378(+) A-I      intronic chr7:23177415(+) A-I      intronic chr7:23191497(+) A-I      intronic chr7:23160382(+) A-I      intronic chr7:23160406(+) A-I      intronic chr7:23160374(+) A-I      intronic chr7:23209633(+) A-I      intronic chr7:23210578(+) A-I      intronic chr7:23210582(+) A-I      intronic chr7:23208728(+) A-I      intronic chr7:23184502(+) A-I      intronic chr7:23209574(+) A-I      intronic chr7:23184492(+) A-I      intronic chr7:23177970(+) A-I      intronic chr7:23155347(+) A-I      intronic chr7:23158560(+) A-I      intronic chr7:23160434(+) A-I      intronic chr7:23158544(+) A-I      intronic chr7:23209667(+) A-I      intronic chr7:23210723(+) A-I      intronic chr7:23185571(+) A-I      intronic chr7:23177931(+) A-I      intronic chr7:23177178(+) A-I      intronic chr7:23178286(+) A-I      intronic chr7:23177198(+) A-I      intronic chr7:23176642(+) A-I      intronic chr7:23209653(+) A-I      intronic chr7:23177938(+) A-I      intronic chr7:23159804(+) A-I      intronic chr7:23185573(+) A-I      intronic chr7:23158462(+) A-I      intronic chr7:23178226(+) A-I      intronic chr7:23193854(+) A-I      intronic chr7:23208760(+) A-I      intronic chr7:23209712(+) A-I      intronic chr7:23151169(+) A-I      intronic chr7:23209778(+) A-I      intronic chr7:23178435(+) A-I      intronic chr7:23153251(+) A-I      intronic chr7:23177616(+) A-I      intronic chr7:23153288(+) A-I      intronic chr7:23177250(+) A-I      intronic chr7:23211535(+) A-I      intronic chr7:23178337(+) A-I      intronic chr7:23208781(+) A-I      intronic chr7:23210666(+) A-I      intronic chr7:23177905(+) A-I      intronic chr7:23185403(+) A-I      intronic chr7:23210656(+) A-I      intronic chr7:23178188(+) A-I      intronic chr7:23159024(+) A-I      intronic chr7:23151264(+) A-I      intronic chr7:23178429(+) A-I      intronic chr7:23160312(+) A-I      intronic chr7:23159693(+) A-I      intronic chr7:23177372(+) A-I      intronic chr7:23208641(+) A-I      intronic chr7:23176689(+) A-I      intronic chr7:23178366(+) A-I      intronic chr7:23177618(+) A-I      intronic chr7:23158422(+) A-I      intronic chr7:23178314(+) A-I      intronic chr7:23159709(+) A-I      intronic chr7:23176793(+) A-I      intronic chr7:23177361(+) A-I      intronic chr7:23159013(+) A-I      intronic chr7:23208733(+) A-I      intronic chr7:23177942(+) A-I      intronic chr7:23178406(+) A-I      intronic chr7:23209643(+) A-I      intronic chr7:23167378(+) A-I      intronic chr7:23158875(+) A-I      intronic chr7:23208729(+) A-I      intronic chr7:23153366(+) A-I      intronic chr7:23208622(+) A-I      intronic chr7:23155369(+) A-I      intronic chr7:23177675(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KLHL7	chr7:23158544(+) A-G intron -    22484847 chr7:23158875(+) A-G intron -    22484847 chr7:23158885(+) A-G intron -    22484847 chr7:23159013(+) A-G intron -    22484847 chr7:23159024(+) A-G intron -    22484847 chr7:23159804(+) A-G intron -    22484847 chr7:23161162(+) A-T intron -    22484847 chr7:23176642(+) A-G intron -    22484847 chr7:23176689(+) A-G intron -    22484847 chr7:23185403(+) A-G intron -    22484847 chr7:23209712(+) A-G intron -    22484847 chr7:23210596(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL7	chr7:23145629-23145630(+) m6A 5'UTR//exon       - chr7:23145684-23145685(+) m6A CDS//exon       - chr7:23145695-23145696(+) m6A CDS//exon       - chr7:23168989-23168990(+) m6A intron       - chr7:23169031-23169032(+) m6A intron       - chr7:23169069-23169070(+) m6A intron       - chr7:23169111-23169112(+) m6A intron       22608085 chr7:23169152-23169153(+) m6A intron       24284625//22608085 chr7:23169223-23169224(+) m6A intron       25456834//22608085 chr7:23169279-23169280(+) m6A intron       25456834//22608085 chr7:23169286-23169287(+) m6A intron       25456834//22608085 chr7:23169302-23169303(+) m6A intron       25456834//22608085 chr7:23169309-23169310(+) m6A intron       25456834//22608085 chr7:23169330-23169331(+) m6A intron       25456834//22608085 chr7:23169346-23169347(+) m6A intron       25456834//22608085 chr7:23169361-23169362(+) m6A intron       25456834//22608085 chr7:23169379-23169380(+) m6A intron       22608085 chr7:23169418-23169419(+) m6A intron       22608085 chr7:23205383-23205384(+) m6A 3'UTR//CDS       24981863//22608085 chr7:23205437-23205438(+) m6A 3'UTR//CDS       24981863//22608085 chr7:23205474-23205475(+) m6A 3'UTR//CDS       24981863//22608085 chr7:23213784-23213785(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:23213809-23213810(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:23213902-23213903(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr7:23213911-23213912(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr7:23213928-23213929(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr7:23213935-23213936(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr7:23213946-23213947(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr7:23215874-23215875(+) m6A 3'UTR       22608085 chr7:23216025-23216026(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KLHL7	Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: KLHL7

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Rep//Targetscan
Support Database	RepTar//VmiReg