Detail Information

Basic Information:


  VIRBase ID:  

VHID00226864

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:           PLEKHA6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US5-1 PLEKHA6
miRBase
Accession/Entrez ID		 MIMAT0001579 22874
Organism Human betaherpesvirus 5 (HHV-5) Homo sapiens
Category miRNA mRNA
Alias - PEPP-3//PEPP3

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLEKHA6
chr1:204301621(-) A-I      intronic
chr1:204301631(-) A-I      intronic
chr1:204301640(-) A-I      intronic
chr1:204301634(-) A-I      intronic
chr1:204301641(-) A-I      intronic
chr1:204301647(-) A-I      intronic
chr1:204301638(-) A-I      intronic
chr1:204297442(-) A-I      intronic
chr1:204277981(-) A-I      intronic
chr1:204217476(-) A-I      intronic
chr1:204299399(-) A-I      intronic
chr1:204298978(-) A-I      intronic
chr1:204298979(-) A-I      intronic
chr1:204202316(-) A-I      intronic
chr1:204217450(-) A-I      intronic
chr1:204280614(-) A-I      intronic
chr1:204202317(-) A-I      intronic
chr1:204277945(-) A-I      intronic
chr1:204277955(-) A-I      intronic
chr1:204217347(-) A-I      intronic
chr1:204198785(-) A-I      intronic
chr1:204298953(-) A-I      intronic
chr1:204271839(-) A-I      intronic
chr1:204217421(-) A-I      intronic
chr1:204216046(-) A-I      intronic
chr1:204297316(-) A-I      intronic
chr1:204213491(-) A-I      intronic
chr1:204324705(-) A-I      intronic
chr1:204216060(-) A-I      intronic
chr1:204202311(-) A-I      intronic
chr1:204280350(-) A-I      intronic
chr1:204324732(-) A-I      intronic
chr1:204217447(-) A-I      intronic
chr1:204325648(-) A-I      intronic
chr1:204264579(-) A-I      intronic
chr1:204216052(-) A-I      intronic
chr1:204217451(-) A-I      intronic
chr1:204202310(-) A-I      intronic
chr1:204202473(-) A-I      intronic
chr1:204298926(-) A-I      intronic
chr1:204322061(-) A-I      intronic
chr1:204217458(-) A-I      intronic
chr1:204217455(-) A-I      intronic
chr1:204281911(-) A-I      intronic
chr1:204301586(-) A-I      intronic
chr1:204303919(-) A-I      intronic
chr1:204203402(-) A-I      intronic
chr1:204272934(-) A-I      intronic
chr1:204303797(-) A-I      intronic
chr1:204325600(-) A-I      intronic
chr1:204217452(-) A-I      intronic
chr1:204203552(-) A-I      intronic
chr1:204203559(-) A-I      intronic
chr1:204213498(-) A-I      intronic
chr1:204325619(-) A-I      intronic
chr1:204254763(-) A-I      intronic
chr1:204277819(-) A-I      intronic
chr1:204198773(-) A-I      intronic
chr1:204217012(-) A-I      intronic
chr1:204280616(-) A-I      intronic
chr1:204298965(-) A-I      intronic
chr1:204216998(-) A-I      intronic
chr1:204301592(-) A-I      intronic
chr1:204216939(-) A-I      intronic
chr1:204217383(-) A-I      intronic
chr1:204202648(-) A-I      intronic
chr1:204322037(-) A-I      intronic
chr1:204216007(-) A-I      intronic
chr1:204324795(-) A-I      intronic
chr1:204324706(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLEKHA6
chr1:204216046(-) A-I intron -    21960545
chr1:204203559(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLEKHA6
chr1:204190078-204190079(-) m6A 3'UTR       24981863//27773535
chr1:204190153-204190154(-) m6A 3'UTR       27773535
chr1:204190175-204190176(-) m6A 3'UTR       27773535
chr1:204190392-204190393(-) m6A 3'UTR       24981863//22575960
chr1:204190429-204190430(-) m6A 3'UTR       24981863//22575960
chr1:204190506-204190507(-) m6A 3'UTR       25456834//24981863
chr1:204190513-204190514(-) m6A 3'UTR       25456834//24981863
chr1:204190591-204190592(-) m6A 3'UTR       25456834//24981863//22575960
chr1:204190648-204190649(-) m6A 3'UTR       25456834//24981863//22575960
chr1:204190825-204190826(-) m6A 3'UTR       24981863
chr1:204190978-204190979(-) m6A 3'UTR       25456834//24981863//27773535
chr1:204191016-204191017(-) m6A 3'UTR       25456834//24981863//27773535
chr1:204191115-204191116(-) m6A 3'UTR       25456834//24981863//27773535
chr1:204191182-204191183(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr1:204191239-204191240(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr1:204191262-204191263(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr1:204191307-204191308(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr1:204191332-204191333(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr1:204191375-204191376(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr1:204191394-204191395(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr1:204191449-204191450(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960
chr1:204191481-204191482(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960
chr1:204191503-204191504(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960
chr1:204191530-204191531(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960
chr1:204191547-204191548(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960
chr1:204191564-204191565(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960
chr1:204210514-204210515(-) m6A CDS       22575960
chr1:204228510-204228511(-) m6A CDS       24284625//25456834//24981863
chr1:204228518-204228519(-) m6A CDS       24284625//25456834//24981863
chr1:204228600-204228601(-) m6A CDS       25456834//24981863
chr1:204228666-204228667(-) m6A CDS       25456834//24981863
chr1:204228773-204228774(-) m6A CDS       24284625//25456834//24981863//27773536
chr1:204228853-204228854(-) m6A CDS       24284625//25456834//24981863//27773535
chr1:204242856-204242857(-) m6A 5'UTR       -
chr1:204243877-204243878(-) m6A 5'UTR       -
chr1:204243919-204243920(-) m6A 5'UTR//exon       -
chr1:204338014-204338015(-) m6A intron       -
chr1:204338043-204338044(-) m6A intron       -
chr1:204338051-204338052(-) m6A intron       -
chr1:204338109-204338110(-) m6A intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PLEKHA6
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hcmv-miR-US5-1
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US5-1
Interactor2: PLEKHA6

Evidence Support:


Prediction-Evidence cRep//miRanda//PITA//Rep//Targetscan
Support Database RepTar//VmiReg

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