Basic Information:

  VIRBase ID:  

VHID00226660

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          RAPGEF2:  NM_001351726     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	RAPGEF2
miRBase Accession/Entrez ID	MIMAT0001579	9693
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CNrasGEF//nRap GEP//NRAPGEP//PDZ-GEF1//PDZGEF1//RA-GEF//RA-GEF-1//RAGEF//Rap-GEP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAPGEF2	chr4:160202592(+) A-I      intronic chr4:160202702(+) A-I      intronic chr4:160202729(+) A-I      intronic chr4:160205956(+) A-I      intronic chr4:160212565(+) A-I      intronic chr4:160212648(+) A-I      intronic chr4:160255421(+) A-I      intronic chr4:160256833(+) A-I      intronic chr4:160255511(+) A-I      intronic chr4:160256828(+) A-I      intronic chr4:160256830(+) A-I      intronic chr4:160258813(+) A-I      intronic chr4:160202621(+) A-I      intronic chr4:160202644(+) A-I      intronic chr4:160202657(+) A-I      intronic chr4:160202661(+) A-I      intronic chr4:160202672(+) A-I      intronic chr4:160258997(+) A-I      intronic chr4:160269142(+) A-I      intronic chr4:160218240(+) A-I      intronic chr4:160158216(+) A-I      intronic chr4:160159066(+) A-I      intronic chr4:160159095(+) A-I      intronic chr4:160173391(+) A-I      intronic chr4:160175041(+) A-I      intronic chr4:160175784(+) A-I      intronic chr4:160175886(+) A-I      intronic chr4:160175896(+) A-I      intronic chr4:160175900(+) A-I      intronic chr4:160175942(+) A-I      intronic chr4:160175962(+) A-I      intronic chr4:160244965(+) A-I      intronic chr4:160174999(+) A-I      intronic chr4:160278256(+) A-I      intronic chr4:160277973(+) A-I      intronic chr4:160212541(+) A-I      intronic chr4:160244971(+) A-I      intronic chr4:160173347(+) A-I      intronic chr4:160205995(+) A-I      intronic chr4:160205972(+) A-I      intronic chr4:160158896(+) A-I      intronic chr4:160206042(+) A-I      intronic chr4:160159039(+) A-I      intronic chr4:160255505(+) A-I      intronic chr4:160155639(+) A-I      intronic chr4:160158302(+) A-I      intronic chr4:160256840(+) A-I      intronic chr4:160202646(+) A-I      intronic chr4:160254391(+) A-I      intronic chr4:160269117(+) A-I      intronic chr4:160159072(+) A-I      intronic chr4:160256824(+) A-I      intronic chr4:160174935(+) A-I      intronic chr4:160158969(+) A-I      intronic chr4:160175953(+) A-I      intronic chr4:160202273(+) A-I      intronic chr4:160202703(+) A-I      intronic chr4:160256834(+) A-I      intronic chr4:160255425(+) A-I      intronic chr4:160255475(+) A-I      intronic chr4:160159076(+) A-I      intronic chr4:160158949(+) A-I      intronic chr4:160202283(+) A-I      intronic chr4:160175890(+) A-I      intronic chr4:160202305(+) A-I      intronic chr4:160158253(+) A-I      intronic chr4:160242628(+) A-I      intronic chr4:160202327(+) A-I      intronic chr4:160202645(+) A-I      intronic chr4:160278257(+) A-I      intronic chr4:160222283(+) A-I      intronic chr4:160158901(+) A-I      intronic chr4:160159055(+) A-I      intronic chr4:160254258(+) A-I      intronic chr4:160158950(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAPGEF2	chr4:160189367(+) A-G intron -    21725310 chr4:160202273(+) A-G intron -    22484847 chr4:160202283(+) A-G intron -    22484847 chr4:160202645(+) A-G intron -    22484847 chr4:160202646(+) A-G intron -    22484847 chr4:160202703(+) A-G intron -    22484847 chr4:160202712(+) A-G intron -    22484847 chr4:160205972(+) A-G intron -    22484847 chr4:160205995(+) A-G intron -    22484847 chr4:160206042(+) A-G intron -    22484847 chr4:160212541(+) A-G intron -    22484847 chr4:160222283(+) A-G intron -    22484847 chr4:160255423(+) A-G intron -    22484847 chr4:160255425(+) A-G intron -    22484847 chr4:160255505(+) A-G intron -    22484847 chr4:160255566(+) A-G intron -    22484847 chr4:160255567(+) A-G intron -    22484847 chr4:160256824(+) A-G intron -    22484847 chr4:160256908(+) A-G intron -    22484847 chr4:160269102(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAPGEF2	chr4:160235770-160235771(+) m6A CDS//exon       24981863 chr4:160235790-160235791(+) m6A CDS//exon       24981863 chr4:160235824-160235825(+) m1A CDS//exon       26863410 chr4:160235827-160235828(+) m6A CDS//exon       24981863 chr4:160235863-160235864(+) m6A CDS//exon       24981863 chr4:160235875-160235876(+) m6A CDS//exon       24981863 chr4:160235890-160235891(+) m6A CDS//exon       24981863 chr4:160235904-160235905(+) m6A CDS//exon       24981863 chr4:160244614-160244615(+) m6A CDS       27773535 chr4:160244719-160244720(+) m6A CDS       24981863//27773535 chr4:160244748-160244749(+) m6A CDS       24981863//27773535 chr4:160247821-160247822(+) m6A exon//intron       24981863 chr4:160251064-160251065(+) m6A CDS//exon       24981863//27773535 chr4:160251110-160251111(+) m6A CDS//exon       24981863//27773535//22575960 chr4:160251119-160251120(+) m6A CDS//exon       24981863//27773535//22575960 chr4:160251129-160251130(+) m6A CDS//exon       24981863//27773535//22575960 chr4:160251135-160251136(+) m6A CDS//exon       24981863//27773535//22575960 chr4:160251146-160251147(+) m6A CDS//exon       24981863//27773535//22575960 chr4:160253788-160253789(+) m6A CDS       24981863//27773535 chr4:160253814-160253815(+) m6A CDS       24981863//27773535 chr4:160253840-160253841(+) m6A CDS       24981863 chr4:160262729-160262730(+) m6A CDS       27773535//22608085 chr4:160262740-160262741(+) m6A CDS       27773535//22608085 chr4:160262746-160262747(+) m6A CDS       27773535//22608085 chr4:160262856-160262857(+) m6A CDS       24284625//24981863//22608085 chr4:160262874-160262875(+) m6A CDS       24284625//24981863//22608085 chr4:160262904-160262905(+) m6A CDS       24981863//22608085 chr4:160262917-160262918(+) m6A CDS       24981863//22608085 chr4:160262965-160262966(+) m6A CDS       24981863 chr4:160267981-160267982(+) m6A CDS       24981863 chr4:160268079-160268080(+) m6A CDS       24981863 chr4:160274030-160274031(+) m6A CDS//exon       24284625 chr4:160274041-160274042(+) m6A CDS//exon       24284625 chr4:160274713-160274714(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr4:160274840-160274841(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:160274916-160274917(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:160274983-160274984(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr4:160275022-160275023(+) Y CDS       26075521 chr4:160275036-160275037(+) m6A CDS       24284625//24981863//27773535//22608085 chr4:160277107-160277108(+) m6A CDS       24284625 chr4:160277115-160277116(+) m6A CDS       24284625 chr4:160277226-160277227(+) m6A CDS       24284625 chr4:160277245-160277246(+) m6A CDS       24284625 chr4:160279272-160279273(+) m6A CDS       24284625//25456834//24981863//22608085 chr4:160279298-160279299(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr4:160279370-160279371(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:160279392-160279393(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:160279503-160279504(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:160279727-160279728(+) m6A 3'UTR       24981863//27773535//22608085 chr4:160279758-160279759(+) m6A 3'UTR       24981863//27773535//22608085 chr4:160279768-160279769(+) m6A 3'UTR       24981863//27773535//22608085 chr4:160280407-160280408(+) m6A 3'UTR       24284625 chr4:160280443-160280444(+) m6A 3'UTR       24284625//24981863 chr4:160280474-160280475(+) m6A 3'UTR       24284625//24981863//22608085 chr4:160280484-160280485(+) m6A 3'UTR       24284625//24981863//22608085 chr4:160280521-160280522(+) m6A 3'UTR       24284625//24981863//22608085 chr4:160280656-160280657(+) m6A 3'UTR       24284625//24981863//22608085 chr4:160280706-160280707(+) m6A 3'UTR       24284625//24981863//22608085 chr4:160280958-160280959(+) m6A 3'UTR       24981863 chr4:160280979-160280980(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RAPGEF2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: RAPGEF2

Evidence Support:

Prediction-Evidence	miRanda//PITA//Rep//Targetscan
Support Database	RepTar//VmiReg