Basic Information:

  VIRBase ID:  

VHID00226555

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US5-1:  MIMAT0001579          RAB11A:  NM_001206836     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US5-1	RAB11A
miRBase Accession/Entrez ID	MIMAT0001579	8766
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	YL8

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB11A	chr15:66167239(+) A-I      intronic chr15:66167236(+) A-I      intronic chr15:66167207(+) A-I      intronic chr15:66167201(+) A-I      intronic chr15:66167199(+) A-I      intronic chr15:66171363(+) A-I      intronic chr15:66179589(+) A-I      intronic chr15:66166759(+) A-I      intronic chr15:66171729(+) A-I      intronic chr15:66179592(+) A-I      intronic chr15:66171728(+) A-I      intronic chr15:66167479(+) A-I      intronic chr15:66167327(+) A-I      intronic chr15:66179573(+) A-I      intronic chr15:66166163(+) A-I      intronic chr15:66168792(+) A-I      intronic chr15:66168654(+) A-I      intronic chr15:66166762(+) A-I      intronic chr15:66179651(+) A-I      intronic chr15:66166719(+) A-I      intronic chr15:66167265(+) A-I      intronic chr15:66171393(+) A-I      intronic chr15:66166117(+) A-I      intronic chr15:66171612(+) A-I      intronic chr15:66177533(+) A-I      intronic chr15:66171802(+) A-I      intronic chr15:66167457(+) A-I      intronic chr15:66174344(+) A-I      intronic chr15:66174069(+) A-I      intronic chr15:66174252(+) A-I      intronic chr15:66171624(+) A-I      intronic chr15:66182525(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB11A	chr15:66152078-66152079(+) m6A exon//intron       24284625//25456834//24981863 chr15:66162410-66162411(+) m6A 5'UTR//intron       24981863 chr15:66169803-66169804(+) m6A 5'UTR//CDS//exon//intron       24981863//26404942//27773535 chr15:66169825-66169826(+) m6A 5'UTR//CDS//exon//intron       24981863//26404942//27773535 chr15:66170147-66170148(+) m6A 5'UTR//CDS//exon//intron       26404942 chr15:66170191-66170192(+) Gm 5'UTR//CDS//intron       - chr15:66172076-66172077(+) m6A CDS//intron       27773535 chr15:66180074-66180075(+) m6A CDS//exon       27773535 chr15:66180143-66180144(+) m6A 3'UTR//CDS//exon       27773535 chr15:66180170-66180171(+) m6A 3'UTR//CDS//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RAB11A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-US5-1	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US5-1
Interactor2: RAB11A

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Western blot
Weak-Evidence	RIP-Chip
Support Database	VmiReg

References:

PMID	24629342	Target region	None
Source	VmiReg	Interactor1 expression	None
Tissue or cell line	293T cells	Interactor2 expression	None
Description	We find that HCMV miRs UL112-1,US5-1, and US5-2 target multiple components of the host secretory pathway, including VAMP3, RAB5C, RAB11A, SNAP23, and CDC42.