Basic Information:

  VIRBase ID:  

VHID00224493

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-UL148D:  MIMAT0001578          METAP1:  NM_015143     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-UL148D	METAP1
miRBase Accession/Entrez ID	MIMAT0001578	23173
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MAP1A//MetAP1A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	METAP1	chr4:99919619(+) A-I      intronic chr4:99976386(+) A-I      intronic chr4:99976381(+) A-I      intronic chr4:99976357(+) A-I      intronic chr4:99976358(+) A-I      intronic chr4:99969730(+) A-I      intronic chr4:99969693(+) A-I      intronic chr4:99976377(+) A-I      intronic chr4:99976395(+) A-I      intronic chr4:99919553(+) A-I      intronic chr4:99972642(+) A-I      intronic chr4:99923962(+) A-I      intronic chr4:99977742(+) A-I      intronic chr4:99922065(+) A-I      intronic chr4:99977744(+) A-I      intronic chr4:99919527(+) A-I      intronic chr4:99932936(+) A-I      intronic chr4:99919615(+) A-I      intronic chr4:99932930(+) A-I      intronic chr4:99923970(+) A-I      intronic chr4:99976427(+) A-I      intronic chr4:99922020(+) A-I      intronic chr4:99932944(+) A-I      intronic chr4:99976557(+) A-I      intronic chr4:99933522(+) A-I      intronic chr4:99976457(+) A-I      intronic chr4:99976420(+) A-I      intronic chr4:99933640(+) A-I      intronic chr4:99920061(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	METAP1	chr4:99919553(+) A-G intron -    22484847 chr4:99919615(+) A-G intron -    22484847 chr4:99932930(+) A-G intron -    22484847 chr4:99932936(+) A-G intron -    22484847 chr4:99932944(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	METAP1	chr4:99982321-99982322(+) m6A CDS       - chr4:99982339-99982340(+) m6A CDS       - chr4:99982352-99982353(+) Gm CDS       - chr4:99982400-99982401(+) m6A CDS       24209618//24981863 chr4:99982544-99982545(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr4:99982590-99982591(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr4:99982619-99982620(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr4:99982659-99982660(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr4:99982733-99982734(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:99982767-99982768(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:99982800-99982801(+) m6A 3'UTR       24284625//24981863//22608085 chr4:99982824-99982825(+) m6A 3'UTR       24284625//24981863//22608085 chr4:99983407-99983408(+) m6A 3'UTR       26404942 chr4:99983733-99983734(+) m6A 3'UTR       27773535 chr4:99983756-99983757(+) m6A 3'UTR       27773535 chr4:99983839-99983840(+) m6A 3'UTR       27773535 chr4:99983872-99983873(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hcmv-miR-UL148D	Exosome K562 cells     24460325
	METAP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-UL148D	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-UL148D
Interactor2: METAP1

Evidence Support:

Prediction-Evidence	miRanda//PITA
Support Database	VmiReg