Basic Information:

  VIRBase ID:  

VHID00223459

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-UL148D:  MIMAT0001578          RUNX3:  NM_001320672     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-UL148D	RUNX3
miRBase Accession/Entrez ID	MIMAT0001578	864
Organism	Human betaherpesvirus 5 (HHV-5)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AML2//CBFA3//PEBP2aC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RUNX3	chr1:25280560(-) A-I      intronic chr1:25280480(-) A-I      intronic chr1:25280506(-) A-I      intronic chr1:25280507(-) A-I      intronic chr1:25280475(-) A-I      intronic chr1:25277602(-) A-I      intronic chr1:25278404(-) A-I      intronic chr1:25277614(-) A-I      intronic chr1:25280472(-) A-I      intronic chr1:25280495(-) A-I      intronic chr1:25277611(-) A-I      intronic chr1:25241743(-) A-I      intronic chr1:25277610(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RUNX3	chr1:25241743(-) A-G intron -    22484847 chr1:25248686(-) G-A intron -    22484847 chr1:25277602(-) A-G intron -    22484847 chr1:25277610(-) A-G intron -    22484847 chr1:25277611(-) A-G intron -    22484847 chr1:25277614(-) A-G intron -    22484847 chr1:25278381(-) T-C intron -    22484847 chr1:25278404(-) A-G intron -    22484847 chr1:25279656(-) C-G intron -    22484847 chr1:25279687(-) G-A intron -    22484847 chr1:25279886(-) C-T intron -    22484847 chr1:25280475(-) A-G intron -    22484847 chr1:25280495(-) A-G intron -    22484847 chr1:25280506(-) A-G intron -    22484847 chr1:25280507(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RUNX3	chr1:25227876-25227877(-) m6A 3'UTR       28052920//26404942 chr1:25227896-25227897(-) m6A 3'UTR       28052920//26404942 chr1:25228014-25228015(-) m6A 3'UTR       28052920//26404942//27371828 chr1:25228047-25228048(-) m6A 3'UTR       24981863//28052920//26404942//27371828 chr1:25228114-25228115(-) m6A 3'UTR       24981863//28052920//26404942//27371828 chr1:25228197-25228198(-) m6A 3'UTR       24981863//28052920//26404942//27371828 chr1:25228264-25228265(-) m6A 3'UTR       24981863//28052920//26404942//27371828 chr1:25228280-25228281(-) m6A 3'UTR       24981863//28052920//26404942//27371828 chr1:25228317-25228318(-) m6A 3'UTR       24981863//28052920//26404942//27371828 chr1:25228518-25228519(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828 chr1:25228559-25228560(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828 chr1:25228577-25228578(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828 chr1:25228599-25228600(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828 chr1:25228727-25228728(-) m6A CDS       24981863//28052920//26404942//27371828 chr1:25228854-25228855(-) m6A CDS       24981863//28052920//26404942//27371828 chr1:25228907-25228908(-) m6A CDS       24981863//28052920 chr1:25229066-25229067(-) m6A CDS//exon       28052920//27371828 chr1:25229141-25229142(-) m6A CDS//exon       27371828 chr1:25229146-25229147(-) m6A CDS//exon       27371828 chr1:25233761-25233762(-) m6A CDS//exon       27371828 chr1:25233853-25233854(-) m6A CDS//exon       27371828 chr1:25233881-25233882(-) m6A CDS//exon       27371828 chr1:25233886-25233887(-) m6A CDS//exon       27371828 chr1:25245746-25245747(-) m6A CDS//exon       27371828 chr1:25254114-25254115(-) m6A CDS//exon       27371828 chr1:25254156-25254157(-) m6A CDS//exon       27371828 chr1:25256177-25256178(-) m6A CDS       27773536 chr1:25256264-25256265(-) m6A CDS//exon       27371828//27773536 chr1:25256342-25256343(-) m6A CDS//exon       27371828 chr1:25291051-25291052(-) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hcmv-miR-UL148D	Exosome K562 cells     24460325
	RUNX3	Exosome Blood     - Nucleus Hunan cervical epithelial cell line no. 1 (HCE1)     29805611

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hcmv-miR-UL148D	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-UL148D
Interactor2: RUNX3

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Rep//Targetscan
Support Database	RepTar//VmiReg