Basic Information:

  VIRBase ID:  

VHID00191480

  Virus:  

Human alphaherpesvirus 2 (HSV2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hsv2-miR-H22:  MIMAT0014704          POLR1E:  NM_001282766     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsv2-miR-H22	POLR1E
miRBase Accession/Entrez ID	MIMAT0014704	64425
Organism	Human alphaherpesvirus 2 (HSV2)	Homo sapiens
Category	miRNA	mRNA
Alias	-	A49//PAF53//PRAF1//RPA49

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	POLR1E	chr9:37499184(+) A-I      intronic chr9:37499191(+) A-I      intronic chr9:37499691(+) A-I      intronic chr9:37500028(+) A-I      intronic chr9:37503426(+) A-I      3'UTR chr9:37503318(+) A-I      3'UTR chr9:37503403(+) A-I      3'UTR chr9:37503311(+) A-I      3'UTR chr9:37503417(+) A-I      3'UTR chr9:37503328(+) A-I      3'UTR chr9:37503477(+) A-I      3'UTR chr9:37503516(+) A-I      3'UTR chr9:37503557(+) A-I      3'UTR chr9:37503388(+) A-I      3'UTR chr9:37503336(+) A-I      3'UTR chr9:37497860(+) A-I      intronic chr9:37497864(+) A-I      intronic chr9:37499555(+) A-I      intronic chr9:37503471(+) A-I      3'UTR chr9:37503392(+) A-I      3'UTR chr9:37503538(+) A-I      3'UTR chr9:37503320(+) A-I      3'UTR chr9:37503495(+) A-I      3'UTR chr9:37503346(+) A-I      3'UTR chr9:37503565(+) A-I      3'UTR chr9:37503325(+) A-I      3'UTR chr9:37503364(+) A-I      3'UTR chr9:37503367(+) A-I      3'UTR chr9:37503313(+) A-I      3'UTR chr9:37499301(+) A-I      intronic chr9:37500014(+) A-I      intronic chr9:37497231(+) A-I      intronic chr9:37499361(+) A-I      intronic chr9:37500123(+) A-I      intronic chr9:37500013(+) A-I      intronic chr9:37500085(+) A-I      intronic chr9:37497889(+) A-I      intronic chr9:37499325(+) A-I      intronic chr9:37500321(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	POLR1E	chr9:37503346(+) A-I exon 3'UTR    15342557   //21960545 chr9:37503350(+) A-I exon 3'UTR    15342557 chr9:37503464(+) A-I exon 3'UTR    15342557 chr9:37503471(+) A-I exon 3'UTR    15342557 chr9:37503490(+) A-I exon 3'UTR    15342557 chr9:37503313(+) A-I intron -    21960545 chr9:37503313(+) A-G intron -    22484847 chr9:37503346(+) A-G intron -    22484847 chr9:37503350(+) A-G intron -    22484847 chr9:37503367(+) A-G intron -    22484847 chr9:37503392(+) A-G intron -    22484847 chr9:37503454(+) A-G intron -    22484847 chr9:37503455(+) A-G intron -    22484847 chr9:37503486(+) G-A intron -    22484847 chr9:37503490(+) A-G intron -    22484847 chr9:37503538(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	POLR1E	chr9:37486031-37486032(+) m6A 5'UTR       24981863 chr9:37503160-37503161(+) m6A 3'UTR//CDS       - chr9:37503167-37503168(+) m6A 3'UTR//CDS       - chr9:37503214-37503215(+) m6A 3'UTR       24284625//22608085 chr9:37503374-37503375(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr9:37503384-37503385(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr9:37503397-37503398(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr9:37503564-37503565(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr9:37503688-37503689(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	POLR1E	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsv2-miR-H22
Interactor2: POLR1E

Evidence Support:

Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//VmiReg