Basic Information:

  VIRBase ID:  

VHID00190038

  Virus:  

Human alphaherpesvirus 2 (HSV2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hsv2-miR-H22:  MIMAT0014704          WDR6:  NM_018031     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsv2-miR-H22	WDR6
miRBase Accession/Entrez ID	MIMAT0014704	11180
Organism	Human alphaherpesvirus 2 (HSV2)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WDR6	chr3:49050922(+) A-I      NonSyn:Asn->Ser chr3:49047988(+) A-I      intronic chr3:49047965(+) A-I      intronic chr3:49047438(+) A-I      intronic chr3:49047383(+) A-I      intronic chr3:49046544(+) A-I      intronic chr3:49046489(+) A-I      intronic chr3:49046481(+) A-I      intronic chr3:49046480(+) A-I      intronic chr3:49046456(+) A-I      intronic chr3:49047381(+) A-I      intronic chr3:49046607(+) A-I      intronic chr3:49046605(+) A-I      intronic chr3:49046395(+) A-I      intronic chr3:49047877(+) A-I      intronic chr3:49047875(+) A-I      intronic chr3:49046586(+) A-I      intronic chr3:49048659(+) A-I      intronic chr3:49048457(+) A-I      intronic chr3:49047767(+) A-I      intronic chr3:49047759(+) A-I      intronic chr3:49047682(+) A-I      intronic chr3:49047679(+) A-I      intronic chr3:49047676(+) A-I      intronic chr3:49047662(+) A-I      intronic chr3:49047661(+) A-I      intronic chr3:49047656(+) A-I      intronic chr3:49047652(+) A-I      intronic chr3:49048431(+) A-I      intronic chr3:49048356(+) A-I      intronic chr3:49048346(+) A-I      intronic chr3:49048265(+) A-I      intronic chr3:49048263(+) A-I      intronic chr3:49048168(+) A-I      intronic chr3:49048152(+) A-I      intronic chr3:49048034(+) A-I      intronic chr3:49046370(+) A-I      intronic chr3:49046338(+) A-I      intronic chr3:49048746(+) A-I      intronic chr3:49046451(+) A-I      intronic chr3:49047651(+) A-I      intronic chr3:49047628(+) A-I      intronic chr3:49047415(+) A-I      intronic chr3:49047224(+) A-I      intronic chr3:49047971(+) A-I      intronic chr3:49047953(+) A-I      intronic chr3:49047915(+) A-I      intronic chr3:49047893(+) A-I      intronic chr3:49046515(+) A-I      intronic chr3:49046567(+) A-I      intronic chr3:49047771(+) A-I      intronic chr3:49047972(+) A-I      intronic chr3:49047225(+) A-I      intronic chr3:49047878(+) A-I      intronic chr3:49048028(+) A-I      intronic chr3:49046535(+) A-I      intronic chr3:49047322(+) A-I      intronic chr3:49048786(+) A-I      intronic chr3:49047692(+) A-I      intronic chr3:49048045(+) A-I      intronic chr3:49047973(+) A-I      intronic chr3:49046591(+) A-I      intronic chr3:49048774(+) A-I      intronic chr3:49048663(+) A-I      intronic chr3:49046589(+) A-I      intronic chr3:49048370(+) A-I      intronic chr3:49047197(+) A-I      intronic chr3:49047416(+) A-I      intronic chr3:49048303(+) A-I      intronic chr3:49048780(+) A-I      intronic chr3:49047718(+) A-I      intronic chr3:49047788(+) A-I      intronic chr3:49048136(+) A-I      intronic chr3:49047829(+) A-I      intronic chr3:49047302(+) A-I      intronic chr3:49046454(+) A-I      intronic chr3:49048647(+) A-I      intronic chr3:49048162(+) A-I      intronic chr3:49046512(+) A-I      intronic chr3:49048329(+) A-I      intronic chr3:49048371(+) A-I      intronic chr3:49047962(+) A-I      intronic chr3:49047963(+) A-I      intronic chr3:49047758(+) A-I      intronic chr3:49048378(+) A-I      intronic chr3:49047990(+) A-I      intronic chr3:49046498(+) A-I      intronic chr3:49048067(+) A-I      intronic chr3:49047789(+) A-I      intronic chr3:49046595(+) A-I      intronic chr3:49048726(+) A-I      intronic chr3:49048204(+) A-I      intronic chr3:49047724(+) A-I      intronic chr3:49047300(+) A-I      intronic chr3:49048172(+) A-I      intronic chr3:49047417(+) A-I      intronic chr3:49046408(+) A-I      intronic chr3:49048096(+) A-I      intronic chr3:49046576(+) A-I      intronic chr3:49048361(+) A-I      intronic chr3:49046476(+) A-I      intronic chr3:49047278(+) A-I      intronic chr3:49048339(+) A-I      intronic chr3:49047916(+) A-I      intronic chr3:49046577(+) A-I      intronic chr3:49048075(+) A-I      intronic chr3:49048029(+) A-I      intronic chr3:49048694(+) A-I      intronic chr3:49048773(+) A-I      intronic chr3:49047590(+) A-I      intronic chr3:49046415(+) A-I      intronic chr3:49048211(+) A-I      intronic chr3:49047987(+) A-I      intronic chr3:49046354(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WDR6	chr3:49046454(+) A-I intron -    22327324 chr3:49046515(+) A-I intron -    22327324 chr3:49047718(+) A-I intron -    22327324 chr3:49047728(+) A-I intron -    22327324 chr3:49047771(+) A-I intron -    22327324 chr3:49047788(+) A-I intron -    22327324 chr3:49047963(+) A-I intron -    22327324 chr3:49048657(+) A-I intron -    22327324 chr3:49048726(+) A-I intron -    22327324 chr3:49048780(+) A-I intron -    21960545   //22327324 chr3:49048370(+) A-I intron -    21960545 chr3:49048371(+) A-I intron -    21960545 chr3:49048786(+) A-I intron -    21960545 chr3:49046336(+) A-I intron -    21960545 chr3:49046353(+) C-T intron -    22484847 chr3:49046354(+) A-G intron -    22484847 chr3:49046376(+) A-G intron -    22484847 chr3:49046408(+) A-G intron -    22484847 chr3:49046415(+) A-G intron -    22484847 chr3:49046432(+) A-G intron -    22484847 chr3:49046444(+) A-G intron -    22484847 chr3:49046454(+) A-G intron -    22484847 chr3:49046464(+) A-G intron -    22484847 chr3:49046476(+) A-G intron -    22484847 chr3:49046495(+) A-G intron -    22484847 chr3:49046512(+) A-G intron -    22484847 chr3:49046515(+) A-G intron -    22484847 chr3:49046524(+) A-G intron -    22484847 chr3:49046535(+) A-G intron -    22484847 chr3:49046567(+) A-G intron -    22484847 chr3:49046576(+) A-G intron -    22484847 chr3:49046577(+) A-G intron -    22484847 chr3:49047230(+) A-G intron -    22484847 chr3:49047290(+) A-G intron -    22484847 chr3:49047417(+) A-G intron -    22484847 chr3:49047718(+) A-G intron -    22484847 chr3:49047724(+) A-G intron -    22484847 chr3:49047771(+) A-G intron -    22484847 chr3:49047788(+) A-G intron -    22484847 chr3:49047789(+) A-G intron -    22484847 chr3:49047939(+) A-G intron -    22484847 chr3:49047962(+) A-G intron -    22484847 chr3:49047963(+) A-G intron -    22484847 chr3:49047984(+) A-G intron -    22484847 chr3:49048026(+) A-G intron -    22484847 chr3:49048028(+) A-G intron -    22484847 chr3:49048029(+) A-G intron -    22484847 chr3:49048072(+) A-G intron -    22484847 chr3:49048136(+) A-G intron -    22484847 chr3:49048162(+) A-G intron -    22484847 chr3:49048172(+) A-G intron -    22484847 chr3:49048271(+) A-G intron -    22484847 chr3:49048330(+) A-G intron -    22484847 chr3:49048339(+) A-G intron -    22484847 chr3:49048371(+) A-G intron -    22484847 chr3:49048617(+) A-G intron -    22484847 chr3:49048618(+) A-G intron -    22484847 chr3:49048635(+) A-G intron -    22484847 chr3:49048647(+) A-G intron -    22484847 chr3:49048657(+) A-G intron -    22484847 chr3:49048663(+) A-G intron -    22484847 chr3:49048691(+) A-G intron -    22484847 chr3:49048721(+) A-G intron -    22484847 chr3:49048726(+) A-G intron -    22484847 chr3:49048734(+) A-G intron -    22484847 chr3:49048773(+) A-G intron -    22484847 chr3:49048774(+) A-G intron -    22484847 chr3:49048780(+) A-G intron -    22484847 chr3:49048786(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDR6	chr3:49044534-49044535(+) m6A 5'UTR       24284625//24981863 chr3:49044565-49044566(+) m6A 5'UTR       24981863 chr3:49044581-49044582(+) m6A 5'UTR       24981863 chr3:49044721-49044722(+) m6A 5'UTR       - chr3:49044880-49044881(+) m6A 5'UTR//CDS//exon       24284625//24981863//22575960 chr3:49044949-49044950(+) m6A 5'UTR//CDS//exon       24284625//24981863//22575960//22608085 chr3:49045549-49045550(+) m6A 5'UTR//intron       24284625//24209618//22608085 chr3:49049100-49049101(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49049139-49049140(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049196-49049197(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049239-49049240(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049266-49049267(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049307-49049308(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049318-49049319(+) Tm 3'UTR//CDS//exon//intron       - chr3:49049433-49049434(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049550-49049551(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049557-49049558(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049655-49049656(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49049851-49049852(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49050130-49050131(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49050255-49050256(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050260-49050261(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050529-49050530(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050546-49050547(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050807-49050808(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49050888-49050889(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49051212-49051213(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49051428-49051429(+) m6A 3'UTR//5'UTR//CDS//exon       24284625//24209618//22575960//22608085 chr3:49051500-49051501(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:49051536-49051537(+) m6A 3'UTR//CDS//exon       24284625 chr3:49051544-49051545(+) m6A 3'UTR//CDS//exon       24284625 chr3:49051666-49051667(+) m6A 3'UTR//CDS//exon       24284625 chr3:49051749-49051750(+) m6A exon//intron       24284625 chr3:49051756-49051757(+) m6A exon//intron       24284625 chr3:49051864-49051865(+) m6A 3'UTR//CDS//exon       24284625 chr3:49052100-49052101(+) m6A 3'UTR//CDS//exon       24284625 chr3:49052585-49052586(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49052638-49052639(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49052767-49052768(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49052913-49052914(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49052918-49052919(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49052930-49052931(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49052990-49052991(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49053044-49053045(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49053109-49053110(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49053295-49053296(+) m6A 3'UTR       24284625//24981863//22575960 chr3:49053311-49053312(+) m6A 3'UTR       24284625//24981863//22575960 chr3:49053317-49053318(+) m6A 3'UTR       24284625//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WDR6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsv2-miR-H22
Interactor2: WDR6

Evidence Support:

Prediction-Evidence	cRep//RNAHybrid
Support Database	RepTar//VmiReg