Detail Information

Basic Information:


  VIRBase ID:  

VHID00159005

  Virus:  

Human alphaherpesvirus 2 (HSV2)

  Host:  

Homo sapiens

  Confidence Score:  

0.9642

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hsv2-miR-H4-5p:           CDKL2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsv2-miR-H4-5p CDKL2
miRBase
Accession/Entrez ID		 MIMAT0010203 8999
Organism Human alphaherpesvirus 2 (HSV2) Homo sapiens
Category miRNA mRNA
Alias - KKIAMRE//P56

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CDKL2
chr4:76518590(-) A-I      intronic
chr4:76518602(-) A-I      intronic
chr4:76551945(-) A-I      intronic
chr4:76518608(-) A-I      intronic
chr4:76551947(-) A-I      intronic
chr4:76551989(-) A-I      intronic
chr4:76518607(-) A-I      intronic
chr4:76546858(-) A-I      intronic
chr4:76546844(-) A-I      intronic
chr4:76546835(-) A-I      intronic
chr4:76546149(-) A-I      intronic
chr4:76541080(-) A-I      intronic
chr4:76541075(-) A-I      intronic
chr4:76538119(-) A-I      intronic
chr4:76538109(-) A-I      intronic
chr4:76521050(-) A-I      intronic
chr4:76521013(-) A-I      intronic
chr4:76520931(-) A-I      intronic
chr4:76520612(-) A-I      intronic
chr4:76519235(-) A-I      intronic
chr4:76519208(-) A-I      intronic
chr4:76519207(-) A-I      intronic
chr4:76516740(-) A-I      intronic
chr4:76516739(-) A-I      intronic
chr4:76506091(-) A-I      intronic
chr4:76506087(-) A-I      intronic
chr4:76519200(-) A-I      intronic
chr4:76519260(-) A-I      intronic
chr4:76518569(-) A-I      intronic
chr4:76518571(-) A-I      intronic
chr4:76518579(-) A-I      intronic
chr4:76519236(-) A-I      intronic
chr4:76519246(-) A-I      intronic
chr4:76519247(-) A-I      intronic
chr4:76546860(-) A-I      intronic
chr4:76518614(-) A-I      intronic
chr4:76519264(-) A-I      intronic
chr4:76506094(-) A-I      intronic
chr4:76519191(-) A-I      intronic
chr4:76506089(-) A-I      intronic
chr4:76551931(-) A-I      intronic
chr4:76551935(-) A-I      intronic
chr4:76519254(-) A-I      intronic
chr4:76520598(-) A-I      intronic
chr4:76512498(-) A-I      intronic
chr4:76520563(-) A-I      intronic
chr4:76510959(-) A-I      intronic
chr4:76505436(-) A-I      intronic
chr4:76510675(-) A-I      intronic
chr4:76536521(-) A-I      intronic
chr4:76510905(-) A-I      intronic
chr4:76515256(-) A-I      intronic
chr4:76512452(-) A-I      intronic
chr4:76520671(-) A-I      intronic
chr4:76516615(-) A-I      intronic
chr4:76505765(-) A-I      intronic
chr4:76534012(-) A-I      intronic
chr4:76520559(-) A-I      intronic
chr4:76541092(-) A-I      intronic
chr4:76520484(-) A-I      intronic
chr4:76512551(-) A-I      intronic
chr4:76506183(-) A-I      intronic
chr4:76515084(-) A-I      intronic
chr4:76520465(-) A-I      intronic
chr4:76515291(-) A-I      intronic
chr4:76520649(-) A-I      intronic
chr4:76543043(-) A-I      intronic
chr4:76512612(-) A-I      intronic
chr4:76545172(-) A-I      intronic
chr4:76505338(-) A-I      intronic
chr4:76520991(-) A-I      intronic
chr4:76515823(-) A-I      intronic
chr4:76505924(-) A-I      intronic
chr4:76535131(-) A-I      intronic
chr4:76511682(-) A-I      intronic
chr4:76505673(-) A-I      intronic
chr4:76512501(-) A-I      intronic
chr4:76505940(-) A-I      intronic
chr4:76512453(-) A-I      intronic
chr4:76515071(-) A-I      intronic
chr4:76510886(-) A-I      intronic
chr4:76515251(-) A-I      intronic
chr4:76515066(-) A-I      intronic
chr4:76552983(-) A-I      intronic
chr4:76510702(-) A-I      intronic
chr4:76505619(-) A-I      intronic
chr4:76505830(-) A-I      intronic
chr4:76538290(-) A-I      intronic
chr4:76510874(-) A-I      intronic
chr4:76520674(-) A-I      intronic
chr4:76520492(-) A-I      intronic
chr4:76520594(-) A-I      intronic
chr4:76505631(-) A-I      intronic
chr4:76520510(-) A-I      intronic
chr4:76552275(-) A-I      intronic
chr4:76543102(-) A-I      intronic
chr4:76510756(-) A-I      intronic
chr4:76511669(-) A-I      intronic
chr4:76546313(-) A-I      intronic
chr4:76505693(-) A-I      intronic
chr4:76505278(-) A-I      intronic
chr4:76506191(-) A-I      intronic
chr4:76510530(-) A-I      intronic
chr4:76515054(-) A-I      intronic
chr4:76505858(-) A-I      intronic
chr4:76520859(-) A-I      intronic
chr4:76505710(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CDKL2
chr4:76555117(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CDKL2
chr4:76503501-76503502(-) m6A 3'UTR       22608085
chr4:76503548-76503549(-) m6A 3'UTR       22608085
chr4:76503563-76503564(-) m6A 3'UTR       22608085
chr4:76503582-76503583(-) m6A 3'UTR       22608085
chr4:76503675-76503676(-) m6A 3'UTR       22608085
chr4:76503703-76503704(-) m6A 3'UTR       22608085
chr4:76504156-76504157(-) m6A 3'UTR       22608085
chr4:76504217-76504218(-) m6A 3'UTR       22608085
chr4:76504245-76504246(-) m6A 3'UTR       22608085
chr4:76504251-76504252(-) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CDKL2
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsv2-miR-H4-5p
Interactor2: CDKL2

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence miRanda//Rep//RNAHybrid//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 30953292 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HeLa cells Interactor2 expression Downregulation
Description Bioinformatics analysis, luciferase report assay, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western blotting demonstrated that miRNA-H4-5p could bind to the 3'-untranslated region (UTR) of cyclin-dependent kinase inhibitor 2A (CDKN2A) and cyclin-dependent kinase-like 2 (CDKL2) to negatively regulate their expression.

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