Basic Information:

  VIRBase ID:  

VHID00158470

  Virus:  

Human alphaherpesvirus 2 (HSV2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hsv2-miR-H4-5p:  MIMAT0010203          HDAC2:  NR_073443     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsv2-miR-H4-5p	HDAC2
miRBase Accession/Entrez ID	MIMAT0010203	3066
Organism	Human alphaherpesvirus 2 (HSV2)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HD2//KDAC2//RPD3//YAF1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HDAC2	chr6:114265700(-) A-I      intronic chr6:114265806(-) A-I      intronic chr6:114265703(-) A-I      intronic chr6:114265885(-) A-I      intronic chr6:114284316(-) A-I      intronic chr6:114284339(-) A-I      intronic chr6:114284385(-) A-I      intronic chr6:114284515(-) A-I      intronic chr6:114284512(-) A-I      intronic chr6:114257976(-) A-I      3'UTR chr6:114257971(-) A-I      3'UTR chr6:114258008(-) A-I      3'UTR chr6:114258007(-) A-I      3'UTR chr6:114257997(-) A-I      3'UTR chr6:114257993(-) A-I      3'UTR chr6:114287552(-) A-I      intronic chr6:114284537(-) A-I      intronic chr6:114287633(-) A-I      intronic chr6:114284016(-) A-I      intronic chr6:114271767(-) A-I      intronic chr6:114283880(-) A-I      intronic chr6:114286598(-) A-I      intronic chr6:114265930(-) A-I      intronic chr6:114258032(-) A-I      3'UTR chr6:114288360(-) A-I      intronic chr6:114288389(-) A-I      intronic chr6:114284276(-) A-I      intronic chr6:114284451(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HDAC2	chr6:114261880(-) T-A exon 3'UTR    21725310 chr6:114283943(-) A-G intron -    22484847 chr6:114284016(-) A-G intron -    22484847 chr6:114284537(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HDAC2	chr6:114259443-114259444(-) m6A 3'UTR       27773535 chr6:114259464-114259465(-) m6A 3'UTR       27773535 chr6:114260979-114260980(-) m6A 3'UTR       27773535 chr6:114261964-114261965(-) m6A 3'UTR//exon       27773535 chr6:114262113-114262114(-) m6A 3'UTR//exon       24981863//27773535 chr6:114262147-114262148(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr6:114262239-114262240(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr6:114262884-114262885(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr6:114262901-114262902(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr6:114264517-114264518(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr6:114264525-114264526(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr6:114264532-114264533(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085 chr6:114264657-114264658(-) m6A CDS//exon       24981863//27773535 chr6:114265457-114265458(-) m6A CDS//exon       24981863//27773535 chr6:114265487-114265488(-) m6A CDS//exon       24981863 chr6:114279852-114279853(-) m6A CDS//exon       24981863//26404942 chr6:114292187-114292188(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HDAC2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsv2-miR-H4-5p
Interactor2: HDAC2

Evidence Support:

Prediction-Evidence	cRep//miRanda//Rep//Targetscan
Support Database	RepTar//VmiReg