Basic Information:

  VIRBase ID:  

VHID00133976

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hsv1-miR-H18:  MIMAT0014696          SH2B1:  NM_001145812     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsv1-miR-H18	SH2B1
miRBase Accession/Entrez ID	MIMAT0014696	25970
Organism	Human alphaherpesvirus 1 (HSV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PSM//SH2B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH2B1	chr16:28882218(+) A-I      intronic chr16:28882712(+) A-I      intronic chr16:28882699(+) A-I      intronic chr16:28882567(+) A-I      intronic chr16:28882735(+) A-I      intronic chr16:28882766(+) A-I      intronic chr16:28882561(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH2B1	chr16:28874624-28874625(+) m6A 5'UTR//intron       25456834//27773536//22608085 chr16:28874632-28874633(+) m6A 5'UTR//intron       25456834//27773536//22608085 chr16:28874657-28874658(+) m6A 5'UTR//intron       25456834//27371828//27773536//22608085 chr16:28874867-28874868(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr16:28875254-28875255(+) m6A 5'UTR//exon//intron       - chr16:28875271-28875272(+) m6A 5'UTR//intron       - chr16:28875277-28875278(+) m6A 5'UTR//intron       - chr16:28875283-28875284(+) m6A 5'UTR//intron       - chr16:28875409-28875410(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr16:28875495-28875496(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr16:28875570-28875571(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr16:28875631-28875632(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr16:28876508-28876509(+) m6A 5'UTR//intron       22608085 chr16:28876565-28876566(+) m6A 5'UTR//intron       24981863//22608085 chr16:28876634-28876635(+) m6A 5'UTR//intron       24981863//22608085 chr16:28876655-28876656(+) m6A 5'UTR//intron       24981863 chr16:28876930-28876931(+) m6A 5'UTR//intron       - chr16:28877533-28877534(+) m6A CDS//intron       24284625//24981863 chr16:28877797-28877798(+) m6A CDS//intron       24284625 chr16:28877937-28877938(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr16:28877973-28877974(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr16:28878004-28878005(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878036-28878037(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878050-28878051(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878087-28878088(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878110-28878111(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878519-28878520(+) m6A 5'UTR//intron       - chr16:28878702-28878703(+) m6A 5'UTR//CDS//intron       24284625 chr16:28878724-28878725(+) Cm CDS//intron       - chr16:28878736-28878737(+) m6A CDS//intron       24284625 chr16:28880356-28880357(+) m6A CDS//intron       24284625 chr16:28880580-28880581(+) m6A CDS//exon//intron       24284625 chr16:28880602-28880603(+) m6A CDS//exon//intron       24284625 chr16:28880608-28880609(+) m6A CDS//exon//intron       24284625 chr16:28880659-28880660(+) m6A CDS//exon//intron       24284625 chr16:28880672-28880673(+) m6A CDS//exon//intron       24284625 chr16:28883121-28883122(+) m6A CDS//exon//intron       24284625 chr16:28883188-28883189(+) m6A CDS//exon//intron       24284625 chr16:28883233-28883234(+) m6A CDS//exon//intron       24284625 chr16:28883246-28883247(+) m6A CDS//exon//intron       24284625 chr16:28883283-28883284(+) m6A CDS//exon//intron       - chr16:28883294-28883295(+) m6A CDS//exon//intron       - chr16:28883909-28883910(+) Y CDS//intron       25219674//26075521 chr16:28884804-28884805(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr16:28884817-28884818(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27371828 chr16:28885170-28885171(+) m6A 3'UTR       24284625 chr16:28885208-28885209(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SH2B1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsv1-miR-H18
Interactor2: SH2B1

Evidence Support:

Prediction-Evidence	miRanda//RNAHybrid//Targetscan
Support Database	VmiReg