Basic Information:

  VIRBase ID:  

VHID00077957

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hsv1-miR-H2-5p:  MIMAT0008398          SKA1:  NM_001039535     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsv1-miR-H2-5p	SKA1
miRBase Accession/Entrez ID	MIMAT0008398	220134
Organism	Human alphaherpesvirus 1 (HSV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C18orf24

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SKA1	chr18:47919373(+) A-I      3'UTR chr18:47919229(+) A-I      3'UTR chr18:47918832(+) A-I      3'UTR chr18:47919174(+) A-I      3'UTR chr18:47919572(+) A-I      3'UTR chr18:47919640(+) A-I      3'UTR chr18:47918813(+) A-I      3'UTR chr18:47904895(+) A-I      intronic chr18:47919605(+) A-I      3'UTR chr18:47919180(+) A-I      3'UTR chr18:47919601(+) A-I      3'UTR chr18:47904867(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SKA1	chr18:47919174(+) A-I intron -    22327324 chr18:47919605(+) A-I intron -    21960545   //22327324 chr18:47919174(+) A-G intron -    21725310   //22484847 chr18:47919605(+) A-G intron -    21725310   //22484847 chr18:47918813(+) A-G intron -    22484847 chr18:47919601(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SKA1	chr18:47901501-47901502(+) m6A 5'UTR       24981863 chr18:47901523-47901524(+) m6A 5'UTR       24981863 chr18:47901557-47901558(+) m6A 5'UTR       24981863 chr18:47901585-47901586(+) m6A 5'UTR//intron       24981863 chr18:47906602-47906603(+) m6A CDS//intron       24981863 chr18:47908500-47908501(+) m6A 5'UTR//CDS       24981863 chr18:47908532-47908533(+) m6A 5'UTR//CDS       24981863 chr18:47908539-47908540(+) m6A 5'UTR//CDS       24981863 chr18:47918592-47918593(+) m6A CDS       24981863//22608085 chr18:47918628-47918629(+) m6A 3'UTR       24981863//22608085 chr18:47918636-47918637(+) m6A 3'UTR       24981863//22608085 chr18:47919483-47919484(+) m6A 3'UTR       24981863//22608085 chr18:47919521-47919522(+) m6A 3'UTR       24981863//22608085 chr18:47919533-47919534(+) m6A 3'UTR       24981863//22608085 chr18:47919600-47919601(+) m6A 3'UTR       24981863//22608085 chr18:47919669-47919670(+) m6A 3'UTR       25456834//24981863//22608085 chr18:47919697-47919698(+) m6A 3'UTR       25456834//24981863//22608085 chr18:47919766-47919767(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SKA1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsv1-miR-H2-5p
Interactor2: SKA1

Evidence Support:

Prediction-Evidence	miRanda//RNAHybrid//Targetscan
Support Database	VmiReg