Detail Information

Basic Information:


  VIRBase ID:  

VHID00070227

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      mdv1-miR-M4-3p:           SPI1:      

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Interactor Information:


Interactor1 Interactor2
Symbol mdv1-miR-M4-3p SPI1
miRBase
Accession/Entrez ID
MIMAT0003925 395879
Organism Gallid alphaherpesvirus 2 Gallus gallus
Category miRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: mdv1-miR-M4-3p
Interactor2: SPI1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//IP//Western blot
Support Database ViRBase

References:


PMID 31189706 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HP8 cells Interactor2 expression Upregulation
Description Results from the reporter assay and direct expression analysis of the Pu.1 target thus confirmed the deletion of miR-M4 and the functional consequences in the mutant C48 clone.

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