Basic Information:

  VIRBase ID:  

VHID00070164

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.8899

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      mdv1-miR-M4-5p:  MIMAT0003924          WEE1:  NM_001031181     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mdv1-miR-M4-5p	WEE1
miRBase Accession/Entrez ID	MIMAT0003924	423045
Organism	Gallid alphaherpesvirus 2	Gallus gallus
Category	miRNA	mRNA
Alias	-	-

Interaction Network (The top 100 interactions):

Interactor1: mdv1-miR-M4-5p
Interactor2: WEE1

Evidence Support:

Strong-Evidence	Luciferase reporter assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRTarget2//PARalyzer
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

[1]PMID	18945769	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	We examined whether MDV-1-miR-M4 and gga-miR-155 shared a common set of target genes by use of a recently developed miRNA target prediction algorithm, MirTarget2 (32, 33). Several of the predicted targets of MDV-1-miR-M4 (see Table S1 in the supplemental material) were common to those already identified as gga-miR-155 targets (http://mirdb.org/cgi-bin/search.cgi).

[2]PMID	24449754	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	293T cells//MSB1 cells	Interactor2 expression	None
Description	As may be observed, we detected significant and selective repression of FLuc expression mediated by these 3'UTRs that was partially or entirely alleviated by mutation of the predicted miR-M4/miR-155 target sites.