Detail Information

Basic Information:


  VIRBase ID:  

VHID00070143

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9806

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol mdv1-miR-M4-5p HIVEP2
miRBase
Accession/Entrez ID		 MIMAT0003924 421672
Organism Gallid alphaherpesvirus 2 Gallus gallus
Category miRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: mdv1-miR-M4-5p
Interactor2: HIVEP2

Evidence Support:


Strong-Evidence Indicator assay//Luciferase reporter assay//Western blot
Weak-Evidence PAR-CLIP
Prediction-Evidence miRTarget2//PARalyzer
Support Database ViRBase//VmiReg

References:


[1]PMID 18945769 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line DF-1 cells Interactor2 expression Downregulation
Description Thus, the reporter assays demonstrated that targets such as PU.1, CEBPE, HIVEP2, BCL2L13, and PDCD6 can be negatively regulated by both gga-miR-155 and MDV-1-miR-M4.
[2]PMID 24449754 Target region CDS
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line MSB1 cells Interactor2 expression None
Description A list of all RISC binding clusters identified, with their predicted miRNAs, is given in Table S1 in the supplemental material. Of these 16,585 binding clusters, PARalyzer predicted 1, 104 cellular mRNAs that were bound by one or more MDV-1 miRNAs, while 1, 183 cellular mRNAs were predicted to be bound by one or more MDV-2 miRNAs.

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