Detail Information

Basic Information:


  VIRBase ID:  

VHID00070141

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9630

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol mdv1-miR-M4-5p TAB2
miRBase
Accession/Entrez ID		 MIMAT0003924 421622
Organism Gallid alphaherpesvirus 2 Gallus gallus
Category miRNA mRNA
Alias - MAP3K7IP2

Interaction Network (The top 100 interactions):


Interactor1: mdv1-miR-M4-5p
Interactor2: TAB2

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//Western blot
Prediction-Evidence miRTarget2//Targetscan
Support Database ViRBase//VmiReg

References:


[1]PMID 18945769 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We examined whether MDV-1-miR-M4 and gga-miR-155 shared a common set of target genes by use of a recently developed miRNA target prediction algorithm, MirTarget2 (32, 33). Several of the predicted targets of MDV-1-miR-M4 (see Table S1 in the supplemental material) were common to those already identified as gga-miR-155 targets (http://mirdb.org/cgi-bin/search.cgi).
[2]PMID 20680360 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells Interactor2 expression None
Description Using luciferase reporter assays, we showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3'untranslated regions (3'UTR) of six cellular genes (GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1[SPI1] and C/EBP).

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