Basic Information:

  VIRBase ID:  

VHID00070093

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9612

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      mdv1-miR-M4-5p:  MIMAT0003924          GPM6B:  NM_001012545     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mdv1-miR-M4-5p	GPM6B
miRBase Accession/Entrez ID	MIMAT0003924	418632
Organism	Gallid alphaherpesvirus 2	Gallus gallus
Category	miRNA	mRNA
Alias	-	M6b

Interaction Network (The top 100 interactions):

Interactor1: mdv1-miR-M4-5p
Interactor2: GPM6B

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Northern blot//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase//VmiReg

References:

[1]PMID	20680360	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells	Interactor2 expression	None
Description	Using luciferase reporter assays, we showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3'untranslated regions (3'UTR) of six cellular genes (GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1[SPI1] and C/EBP).

[2]PMID	21277611	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells	Interactor2 expression	None
Description	An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs.