Basic Information:

  VIRBase ID:  

VHID00070047

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9612

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      mdv1-miR-M4-5p:  MIMAT0003924          MYB:  NM_205306     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mdv1-miR-M4-5p	MYB
miRBase Accession/Entrez ID	MIMAT0003924	396244
Organism	Gallid alphaherpesvirus 2	Gallus gallus
Category	miRNA	mRNA
Alias	-	c-myb

Interaction Network (The top 100 interactions):

Interactor1: mdv1-miR-M4-5p
Interactor2: MYB

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Northern blot//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase//VmiReg

References:

[1]PMID	20680360	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells	Interactor2 expression	None
Description	Using luciferase reporter assays, we showed that mdv1-miR-M4-5P and miR-155 efficiently targeted a common set of 3'untranslated regions (3'UTR) of six cellular genes (GPM6B, RREB1, c-Myb, MAP3K7IP2, PU.1[SPI1] and C/EBP).

[2]PMID	21277611	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells	Interactor2 expression	None
Description	An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs.

[3]PMID	24449754	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	293T cells	Interactor2 expression	None
Description	As may be observed, we detected significant and selective repression of FLuc expression mediated by these 3'UTRs that was partially or entirely alleviated by mutation of the predicted miR-M4/miR-155 target sites.