Detail Information

Basic Information:


  VIRBase ID:  

VHID00000006

  Virus:  

Human mastadenovirus C (Human adenovirus 5)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol VAII DICER1
miRBase
Accession/Entrez ID		 VAII 23405
Organism Human mastadenovirus C (Human adenovirus 5) Homo sapiens
Category lncRNA mRNA
Alias - DCR1//Dicer//Dicer1e//GLOW//HERNA//K12H4.8-LIKE//MNG1//RMSE2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DICER1
chr14:95617269(-) A-I      intronic
chr14:95617234(-) A-I      intronic
chr14:95617267(-) A-I      intronic
chr14:95617338(-) A-I      intronic
chr14:95617317(-) A-I      intronic
chr14:95608532(-) A-I      intronic
chr14:95614285(-) A-I      intronic
chr14:95617280(-) A-I      intronic
chr14:95597526(-) A-I      intronic
chr14:95616760(-) A-I      intronic
chr14:95616576(-) A-I      intronic
chr14:95616771(-) A-I      intronic
chr14:95617357(-) A-I      intronic
chr14:95617355(-) A-I      intronic
chr14:95615385(-) A-I      intronic
chr14:95616741(-) A-I      intronic
chr14:95617292(-) A-I      intronic
chr14:95613681(-) A-I      intronic
chr14:95597535(-) A-I      intronic
chr14:95617300(-) A-I      intronic
chr14:95617325(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DICER1
chr14:95615385(-) A-G intron -    22484847
chr14:95616576(-) A-G intron -    22484847
chr14:95617280(-) A-G intron -    22484847
chr14:95617300(-) A-G intron -    22484847
chr14:95617325(-) A-G intron -    22484847
chr14:95617355(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DICER1
chr14:95552701-95552702(-) m6A 3'UTR       27773535
chr14:95553018-95553019(-) m6A 3'UTR       27773535
chr14:95553532-95553533(-) m6A 3'UTR       -
chr14:95554128-95554129(-) m6A 3'UTR       24981863
chr14:95555754-95555755(-) m6A 3'UTR//intron       27773535
chr14:95555818-95555819(-) m6A 3'UTR//intron       27773535
chr14:95555825-95555826(-) m6A 3'UTR//intron       27773535
chr14:95556649-95556650(-) m6A 3'UTR//intron       27773535
chr14:95556677-95556678(-) m6A 3'UTR//intron       27773535//22608085
chr14:95556757-95556758(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556800-95556801(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556805-95556806(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556812-95556813(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556832-95556833(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556986-95556987(-) m6A CDS//exon       24981863//27773535
chr14:95560387-95560388(-) m6A CDS       27773535
chr14:95560420-95560421(-) m6A CDS       27773535
chr14:95560450-95560451(-) m6A CDS       27773535
chr14:95561748-95561749(-) m6A 3'UTR//intron       27773535
chr14:95561756-95561757(-) m6A 3'UTR//intron       27773535
chr14:95562141-95562142(-) m6A CDS//intron       22608085
chr14:95562284-95562285(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:95562349-95562350(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:95562409-95562410(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562467-95562468(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562574-95562575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562655-95562656(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562912-95562913(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95563020-95563021(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95563042-95563043(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566153-95566154(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566230-95566231(-) m6A CDS       27773535
chr14:95569847-95569848(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569867-95569868(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569935-95569936(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95570052-95570053(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95570148-95570149(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:95570277-95570278(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570314-95570315(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570448-95570449(-) m6A CDS//exon//intron       24284625//22608085
chr14:95572444-95572445(-) m6A CDS//exon       27773535
chr14:95572465-95572466(-) m6A CDS//exon       27773535
chr14:95574735-95574736(-) Tm CDS       -
chr14:95583004-95583005(-) m6A CDS//intron       24981863//27773535
chr14:95583967-95583968(-) m6A CDS//exon       24981863//27773535
chr14:95583991-95583992(-) m6A CDS//exon       24981863//27773535
chr14:95584024-95584025(-) m6A CDS//exon       24981863//27773535
chr14:95584069-95584070(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590535-95590536(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590614-95590615(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95590744-95590745(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590771-95590772(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590862-95590863(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590906-95590907(-) m6A CDS       24284625//24981863//22608085
chr14:95590924-95590925(-) m6A CDS       24284625//24981863//22608085
chr14:95590966-95590967(-) m6A CDS       24284625//24981863//22608085
chr14:95590994-95590995(-) m6A CDS       24284625//24981863//22608085
chr14:95592919-95592920(-) m6A CDS       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DICER1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: VAII
Interactor2: DICER1

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//Western blot
Support Database ViRBase

References:


PMID 16014917 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line 293 cells Interactor2 expression None
Description The VA RNAs bind Dicer and function as competitive substrates squelching Dicer. Further, we show that VA RNAI and VA RNAII are processed by Dicer, both in vitro and during a lytic infection, and that the resulting short interfering RNAs (siRNAs) are incorporated into active RISC.

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