Detail Information

Basic Information:


  VIRBase ID:  

HVID00009707

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-2277-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0011777 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-2277-3p
rs1008172445 chr5:93620722    G/A
rs1008172445 chr5:93620722    G/C
rs1023614995 chr5:93620711    A/T
rs1217788501 chr5:93620715    A/C
rs1217788501 chr5:93620715    A/G
rs1217788501 chr5:93620715    A/T
rs1370205002 chr5:93620711    AGCCAG/A
rs1380071238 chr5:93620719    A/T
rs1420153837 chr5:93620721    G/T
rs1428277913 chr5:93620702    CGCCGGCCGAGCCAG/C
rs181040414 chr5:93620714    C/G
rs181040414 chr5:93620714    C/T
rs550720421 chr5:93620710    G/T
rs73772915 chr5:93620716    G/C
rs890397500 chr5:93620720    G/A
rs899416807 chr5:93620712    G/A
rs994970632 chr5:93620713    C/G
rs1019609621 chr5:93620724    G/A
rs1273375895 chr5:93620725    C/A
rs753547235 chr5:93620723    C/T
rs759366475 chr5:93620726    T/A
rs759366475 chr5:93620726    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-2277-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Mesenchymal stem cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-2277-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence IntaRNA//miRanda//psRNATarget
Support Database ViRBase

References:


[1]PMID 32765592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description From our rigorous analysis pipeline, which covers three different well-established algorithms (IntaRNA, miRanda, and psRNATarget) to predict RNA-RNA interactions, we have identified 122 and 106 host antiviral miRNAs against SARS-CoV (R) and SARS-CoV-2 (R), respectively (Figures 2A,B, Supplementary File 2).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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